TSC1

  • Official Full Name

    tuberous sclerosis 1

  • Overview

    The tuberous sclerosis 1 protein interacts with TSC2 (tuberin) to form a functional tumor suppressor complex that regulates cell proliferation and growth. Tuberous sclerosis is an autosomal dominant tumor suppressor gene syndrome due to inactivating mutations in either TSC1 or TSC. The TSC1/TSC2 complex functions as a negative regulator of mTOR activity and inhibits 70S6K and 4EBP1 phosphorylation in cells. The mechanism of inhibition is to due in part to intrinsic GAP activity acting upon the small GTPase, Rheb. The PI-3K pathway inhibits TSC1/TSC2 via Akt phosphorylation and subsequent destabilization of the functional TSC1/TSC2 complex. Activation of the complex occurs via AMPK,Which senses stress and energy levels in the cell. Phosphorylation of the TSC1/TSC2 complex by AMPK results in activation of the complex and inhibition of mTOR activity.
  • Synonyms

    TSC1; tuberous sclerosis 1; TSC; hamartin; KIAA0243; LAM; tumor suppressor; tuberous sclerosis 1 protein; MGC86987;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TSC1-725HCL Recombinant Human TSC1 293 Cell Lysate HEK293 N/A
Human TSC1-494H Recombinant Human TSC1 Protein, His-tagged E.coli N-His
Mouse TSC1-17473M Recombinant Mouse TSC1 Protein Mammalian Cell His
Mouse TSC1-9665M-B Recombinant Mouse TSC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse TSC1-9665M Recombinant Mouse TSC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TSC1-6309R Recombinant Rat TSC1 Protein Mammalian Cell His
Rat TSC1-5966R Recombinant Rat TSC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TSC1-5966R-B Recombinant Rat TSC1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TSC1-7530Z Recombinant Zebrafish TSC1 Mammalian Cell His
Zebrafish TSC1-7529Z Recombinant Zebrafish TSC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TSC1 Related Articles
  • TSC1 Related Signal Pathway

TSC1 involved in several pathways and played different roles in them. We selected most pathways TSC1 participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Phospholipase D signaling pathwayMAPK1;PLD1;PPAP2C;SHC1;RALGDS;PIK3CG;GAB1;MTOR;INS
mTOR signaling pathwayPIK3R2;PIK3CD;RRAGCB;HIF1AB;RPS6KA3B;IGF1;INSB;RPS6KA1;TSC1A
PIK-Akt signaling pathwaySPP1;GNG2;FGF4;GSK3B;ANGPT4;G6PC;PRKAA1;INSR;CRTC2
AMPK signaling pathwayPIK3CD;PIK3R1;PPARGC1A;PDPK1;PPP2R2A;INSR;AKT1S1;PIK3R2;GYS1
Insulin signaling pathwayPRKACG;EIF4E1C;PPP1CA;FBP1A;PHKB;LIPE;ELK1;RAPGEF1B;PRKAB2
Choline metabolism in cancerPIK3R2;PLA2G4F;PPAP2A;GPCPD1;PIK3R1;PDPK1;PDGFRB;PRKCG;DGKQ

TSC1 has several biochemical functions, for example, GTPase activating protein binding, GTPase regulator activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC1 itself. We selected most functions TSC1 had, and list some proteins which have the same functions with TSC1. You can find most of the proteins on our site.

Function Related Protein
GTPase activating protein bindingRGS14;GAPVD1;FMNL1;TUBB;GNAO1;PIN1;GNAI3;MEX3B;PLCD1
GTPase regulator activityARL2BP;GPSM2L;GPSM1B;DNAJA3;TSC1;RALGDS;RGS12B;KRIT1;PCP2
chaperone bindingTSC1;BAG5;CDKN1B;PRNP;TSACC;TBCD;TP53;CDC37;PFDN6
protein N-terminus bindingSTXBP1;TRAF6;NPAT;SLA2;RBPJ;EXOC4;NTSR1;ATM;ID1
protein bindingTUBB2A;CALU;CORO1C;MYBL2;UBLCP1;TDRD7;FGFR1B;CDX1;CCDC170

TSC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC1.

TSC2; IKBKB; YWHAG; NGFRAP1

Carneiro, BA; Meeks, JJ; et al. Emerging therapeutic targets in bladder cancer. CANCER TREATMENT REVIEWS 41:170-178(2015).
Moch, H; Montironi, R; et al. Oncotargets in Different Renal Cancer Subtypes. CURRENT DRUG TARGETS 16:125-135(2015).
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