TSC1 Protein

TSC1

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TSC1

Official Full Name tuberous sclerosis 1
Background The tuberous sclerosis 1 protein interacts with TSC2 (tuberin) to form a functional tumor suppressor complex that regulates cell proliferation and growth. Tuberous sclerosis is an autosomal dominant tumor suppressor gene syndrome due to inactivating mutations in either TSC1 or TSC. The TSC1/TSC2 complex functions as a negative regulator of mTOR activity and inhibits 70S6K and 4EBP1 phosphorylation in cells. The mechanism of inhibition is to due in part to intrinsic GAP activity acting upon the small GTPase, Rheb. The PI-3K pathway inhibits TSC1/TSC2 via Akt phosphorylation and subsequent destabilization of the functional TSC1/TSC2 complex. Activation of the complex occurs via AMPK,Which senses stress and energy levels in the cell. Phosphorylation of the TSC1/TSC2 complex by AMPK results in activation of the complex and inhibition of mTOR activity.
Synonyms TSC1; tuberous sclerosis 1; TSC; hamartin; KIAA0243; LAM; tumor suppressor; tuberous sclerosis 1 protein; MGC86987
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse TSC1-17473M Recombinant Mouse TSC1 Protein Mammalian Cell His
    Rat TSC1-6309R Recombinant Rat TSC1 Protein Mammalian Cell His
    Zebrafish TSC1-7529Z Recombinant Zebrafish TSC1 Mammalian Cell His
    Zebrafish TSC1-7530Z Recombinant Zebrafish TSC1 Mammalian Cell His
    Human TSC1-725HCL Recombinant Human TSC1 293 Cell Lysate HEK293 N/A
    Human TSC1-494H Recombinant Human TSC1 Protein, His-tagged E.coli N-His

    TSC1 involved in several pathways and played different roles in them. We selected most pathways TSC1 participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway AGPAT5; PLCB4; AKT2; PLCG2; AKT1; GRM5; MAP2K1; FCER1G; INS1; INSR
    mTOR signaling pathway INSB; CAB39L; RPS6; RRAGCB; IRS1; RPS6KA3B; MAPK3; AKT2L; DEPDC6; RPS6KB1B
    PIK-Akt signaling pathway PPP2R5C; PPP2CA; HSP90AA1; NR4A1; PPP2R2D; ANGPT4; LAMB3; TSC2; KLK1B4; GNG11
    AMPK signaling pathway MLYCD; PPP2R1B; CAMKK2; ADIPOR1; CREB3; FOXO3; FBP2; SCD; PRKAA2; CAB39L
    Insulin signaling pathway G6PC; MAPK8A; PYGB; G6PCA.1; PIK3R3A; PIK3CB; SLC2A4; PHKA2; RPS6; INS2
    Choline metabolism in cancer PDGFA; PPAP2B; AKT2; PIP5K1A; Pdgfa&Pdgfb; PLA2G4F; SLC22A3; PDGFC; PIK3CD; SLC22A1

    TSC1 has several biochemical functions, for example, GTPase activating protein binding, GTPase regulator activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC1 itself. We selected most functions TSC1 had, and list some proteins which have the same functions with TSC1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activating protein binding MEX3B; TUBB; CDH1; RGS14; GNAI3; GNAI1; PIN1; GAPVD1; GNAO1; TSC1
    GTPase regulator activity GPSM2L; RHPN1; RIMS1; WASL; RALGDS; TSC1A; TSC1; GPSM1B; TSC1B; RGS12
    chaperone binding DNAJB7; BAG4; HSP104; PFDN4; HLA-B; ERP29; GET4; PRNP; DNAJA4; TSC1
    protein N-terminus binding KCNIP2; GTF2H2; FEZ1; STX5A; EIF5A; SCFD1; RPS21; STX1A; ZWINT; PDLIM5
    protein binding EPB41; FZD8; LIN37; MUTED; HSPB8; CA; NOL6; RASSF2; LIN28B; PRPF31

    TSC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC1.

    TSC2; IKBKB; YWHAG; NGFRAP1

    Carneiro, BA; Meeks, JJ; et al. Emerging therapeutic targets in bladder cancer. CANCER TREATMENT REVIEWS 41:170-178(2015).
    Moch, H; Montironi, R; et al. Oncotargets in Different Renal Cancer Subtypes. CURRENT DRUG TARGETS 16:125-135(2015).

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