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TSC1

Official Full Name

tuberous sclerosis 1
Overview

The tuberous sclerosis 1 protein interacts with TSC2 (tuberin) to form a functional tumor suppressor complex that regulates cell proliferation and growth. Tuberous sclerosis is an autosomal dominant tumor suppressor gene syndrome due to inactivating mutations in either TSC1 or TSC. The TSC1/TSC2 complex functions as a negative regulator of mTOR activity and inhibits 70S6K and 4EBP1 phosphorylation in cells. The mechanism of inhibition is to due in part to intrinsic GAP activity acting upon the small GTPase, Rheb. The PI-3K pathway inhibits TSC1/TSC2 via Akt phosphorylation and subsequent destabilization of the functional TSC1/TSC2 complex. Activation of the complex occurs via AMPK,Which senses stress and energy levels in the cell. Phosphorylation of the TSC1/TSC2 complex by AMPK results in activation of the complex and inhibition of mTOR activity.
Synonyms

TSC1; tuberous sclerosis 1; TSC; hamartin; KIAA0243; LAM; tumor suppressor; tuberous sclerosis 1 protein; MGC86987;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TSC1-725HCL	Recombinant Human TSC1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TSC1-494H	Recombinant Human TSC1 Protein, His-tagged	E.coli	N-His	Asp998-Ser1164	Inquiry
Human	TSC1-4194H	Recombinant Human TSC1 protein(690-993aa), His-tagged	E.coli	N-His	690-993aa	Inquiry
Mouse	TSC1-17473M	Recombinant Mouse TSC1 Protein	Mammalian Cell	His		Inquiry
Mouse	TSC1-9665M-B	Recombinant Mouse TSC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	TSC1-9665M	Recombinant Mouse TSC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TSC1-6309R	Recombinant Rat TSC1 Protein	Mammalian Cell	His		Inquiry
Rat	TSC1-5966R	Recombinant Rat TSC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TSC1-5966R-B	Recombinant Rat TSC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TSC1-7530Z	Recombinant Zebrafish TSC1	Mammalian Cell	His		Inquiry
Zebrafish	TSC1-7529Z	Recombinant Zebrafish TSC1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
TSC1 Related Signal Pathway

TSC1 involved in several pathways and played different roles in them. We selected most pathways TSC1 participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phospholipase D signaling pathway	PDGFD;LPAR4;AGPAT3;CXCR2;INSR;GRM1;GNA12;FCER1A;CYTH4
mTOR signaling pathway	AKT2;ULK2;EIF4E1C;AKT1S1;INS;STK11;RICTOR;AKT2L;RPS6KA3B
PIK-Akt signaling pathway	RXRA;CASP9;PDGFRB;PPP2R5C;Ifna11;TLR4;GNGT2;KIT;IFNA4
AMPK signaling pathway	RPS6KB2;PPP2R5A;CREB3L2;LEP;CPT1A;HNF4A;G6PC2;MAP3K7;PRKAB2
Insulin signaling pathway	PKLR;CALM3A;SHC2;ARAF;PPP1CC;PTPRFB;RPS6KB2;PHKA2;PIK3R1
Choline metabolism in cancer	LYPLA1;RHEB;PIK3R5;RALGDS;PIK3CB;PIK3CA;AKT2;DGKZ;PRKCG

TSC1 has several biochemical functions, for example, GTPase activating protein binding, GTPase regulator activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC1 itself. We selected most functions TSC1 had, and list some proteins which have the same functions with TSC1. You can find most of the proteins on our site.

Function	Related Protein
GTPase activating protein binding	CDH1;GNAI1;GNAO1;MEX3B;FMNL1;TUBB;GNAI3;RGS14;PLCD1
GTPase regulator activity	RALGDS;DNAJA3;ARL2BP;GPSM1B;TSC1;RHPN1;GPSM2;KRIT1;RUNDC3A
chaperone binding	TP53;ST13;BAG2;HSPD1;INS1;DNAJA4;USP13;GET4;DNAJA2
protein N-terminus binding	TRP53;STX5A;MYO7A;TSC1;ID1;TARBP2;SDCBP;KCNQ2;ERCC5
protein binding	TULP1;BEGAIN;ATP6V1B2;GYPC;CA8;EFTUD2;CC2D2A;NOL3;ABCF3

TSC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC1.

TSC2; IKBKB; YWHAG; NGFRAP1