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Recombinant Human TSC1 Protein, His-tagged

Cat.No. : TSC1-494H
Product Overview : Recombinant Human TSC1 Protein (Asp998-Ser1164) with N-His tag was expressed in E. coli.
  • Specification
  • Gene Information
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Description : This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Source : E. coli
Species : Human
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 21.2 kDa
Accurate Molecular Mass: 26 kDa
Protein length : Asp998-Ser1164
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : TSC1 tuberous sclerosis 1 [ Homo sapiens (human) ]
Official Symbol : TSC1
Synonyms : TSC1; tuberous sclerosis 1; TSC; hamartin; KIAA0243; LAM; tumor suppressor; tuberous sclerosis 1 protein; MGC86987
Gene ID : 7248
mRNA Refseq : NM_000368
Protein Refseq : NP_000359
MIM : 605284
UniProt ID : Q92574

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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