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Official Full Name ubiquitin specific peptidase 10
Background Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and;degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme;specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and;cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in;the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.
Synonyms USP10; ubiquitin specific peptidase 10; ubiquitin specific protease 10; ubiquitin carboxyl-terminal hydrolase 10; KIAA0190; UBPO; ubiquitin thioesterase 10; deubiquitinating enzyme 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • Flag
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human USP10-12H Recombinant Human USP10 Protein, His-tagged Insect Cell His
    Human USP10-146H Recombinant Human USP10, His-SUMO-tagged E.coli His/SUMO
    Human USP10-3615H Recombinant Human USP10, GST-tagged E.coli GST
    Human USP10-391H Recombinant Human USP10, Flag-tagged Insect Cell Flag
    Human USP10-474HCL Recombinant Human USP10 293 Cell Lysate HEK293 N/A
    Mouse USP10-17899M Recombinant Mouse USP10 Protein Mammalian Cell His
    Rat USP10-6469R Recombinant Rat USP10 Protein Mammalian Cell His
    Chicken USP10-1282C Recombinant Chicken USP10 Mammalian Cell His

    usp10 involved in several pathways and played different roles in them. We selected most pathways usp10 participated on our site, such as DNA Damage Bypass, DNA Repair, Termination of translesion DNA synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with usp10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Damage Bypass MAD2L2; POLD3; ZBTB32; USP43A; UBE2L6; KIAA0101; DDB1; SPRTN; DTL; RAD18
    DNA Repair YY1; TCEA1; FAM175A; BABAM1; EYA2; TFPT; COPS6; RAD9A; RNF111; PPIE
    Termination of translesion DNA synthesis POLI; USP43; USP43A; KIAA0101; USP10
    Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template USP43A; USP10; POLI; SPRTN; USP43; KIAA0101

    usp10 has several biochemical functions, for example, cysteine-type endopeptidase activity, ion channel binding, p53 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by usp10 itself. We selected most functions usp10 had, and list some proteins which have the same functions with usp10. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity CASP9; USP15; CTSZ; CASP10; CASPB; DUB1; CTSL1B; ATG4B; CTSLL; USP45
    ion channel binding LRRK2; ABCC9; CALM; HOMER1; NEDD4L; SNTA1; FAM115A; ANK2; RIMS1; AKAP9
    p53 binding BCL2L12; USP10; TRP63; MDM2; SMARCA4; TP53; BANP; CREBBP; ZNF385A; KDM1A
    poly(A) RNA binding ZAK; TTC6; ZC3H7A; RPL10A; DROSHA; UCHL5; DDX56; TRA2A; HIST1H4B; UBC
    protein binding O3far1; FAM123A; S100A8; DACH1; CCT5; AAK1; GLYCTK; TNFAIP3; ACTG1; PPP1R15B
    ubiquitin-specific protease activity OTUD6A; USP28; OTUB2; USP44; USP18; USP8; ATXN3L; USP10; USP38; UCHL5

    usp10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with usp10 here. Most of them are supplied by our site. Hope this information will be useful for your research of usp10.

    G3BP2; YBX1; ZC3H12A; EIF4G3; ULK1; G3BP1; EIF4G1 variant protein; CELF1; GAR1; RAD51

    Dauphinee, SM; Richer, E; et al. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. GENES AND IMMUNITY 15:282-292(2014).
    Feng, AP; He, YM; et al. Expression of USP15, T beta R-I and Smad7 in psoriasis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 34:415-419(2014).

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