USP10 involved in several pathways and played different roles in them. We selected most pathways USP10 participated on our site, such as DNA Damage Bypass, DNA Repair, Termination of translesion DNA synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| DNA Damage Bypass |
USP43; POLD3; DDB1; DTL; USP43A; ZBTB32; POLI; RAD18; KIAA0101; MAD2L2 |
| DNA Repair |
COPS7B; GEN1; PAXIP1; EYA4; USP43A; PPP4R2A; TCEA1; UBE2V2; CHEK2; YY1A |
| Termination of translesion DNA synthesis |
KIAA0101; USP10; USP43; POLI; USP43A |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
USP43A; USP43; USP10; POLI; KIAA0101; SPRTN |
USP10 has several biochemical functions, for example, cysteine-type endopeptidase activity, ion channel binding, p53 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP10 itself. We selected most functions USP10 had, and list some proteins which have the same functions with USP10. You can find most of the proteins on our site.
| Function |
Related Protein |
| cysteine-type endopeptidase activity |
ATG4A; CTSF; USP50; USP16; CASP6L1; CTSM; USP12A; ATG4B; CASPBL; CTSS |
| ion channel binding |
TRAPPC2; DIAPH1; AKAP6; GPD1L; DIAP1; PRKCSH; KCNE1L; KCNIP1; YWHAE; RIMS3 |
| p53 binding |
CDK5; ZFP346; SIRT1; ZMAT3; TRIM29; ZMAT4; TRIAP1; RFFL; BRD4; CDKN2AIP |
| poly(A) RNA binding |
H1FX; RBM15B; IGF2BP3; GM5506; MEPCE; DARS; TAF15; GTPBP1; AGO1; PTCD3 |
| protein binding |
SYF2; L3MBTL3; ERLEC1; CAMLG; MFAP4; RIMS2; DHH; SIAH1; DSC2; TTR |
| ubiquitin-specific protease activity |
USP22; COPS5; USP8; USP34; ATXN3L; OTUD4; USP5; UCHL3; BRCC3; UFD1L |
USP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP10.
G3BP2; YBX1; ZC3H12A; EIF4G3; ULK1; G3BP1; EIF4G1 variant protein; CELF1; GAR1; RAD51
Dauphinee, SM; Richer, E; et al. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. GENES AND IMMUNITY 15:282-292(2014).
Feng, AP; He, YM; et al. Expression of USP15, T beta R-I and Smad7 in psoriasis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 34:415-419(2014).
