Recombinant Human USP10 Protein, His-tagged
Cat.No. : | USP10-12H |
Product Overview : | Recombinant Human USP10(Leu45~Asp514) fused with His tag at C-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | Ubiquitin carboxyl-terminal hydrolase 10 (USP10) is a specialized cysteine protease with a predicted molecular weight of 87 kDa. USP10 is a member of the peptidase C19 family and the human protein shares 83% amino acid sequence identity with its mouse ortholog. Reported USP10 targets include p53, BECN1, SNX3 and CFTR. USP10 translocates to the nucleus in response to DNA damage and deubiquitinates p53, thus regulating the p53-dependent DNA damage response. USP10 deubiquitination of BECN1 leads to stabilization of PIK3C3/VPS34-containing complexes which drives autophagy. The small molecule Spautin-1 exerts its potent inhibitory effects on autophagy partially through the inhibition of USP10 activity. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | X mg/ml (X μM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 10% (v/v) Glycerol, 1 mM TCEP |
Molecular Mass : | 88 kDa |
Identity : | Reaction conditions will need to be optimized for each specific application. We recommend an initial His6-USP10 concentration of 20-100 nM in reactions utilizing Ubiquitin-AMC or Ubiquitin-Rhodamine substrates. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain. |
Stability : | Avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 centigrade as supplied. 3 months, -70 centigrade under sterile conditions after opening. |
Gene Name : | USP10 ubiquitin specific peptidase 10 [ Homo sapiens ] |
Official Symbol : | USP10 |
Synonyms : | USP10; ubiquitin specific peptidase 10; ubiquitin specific protease 10; ubiquitin carboxyl-terminal hydrolase 10; KIAA0190; UBPO; ubiquitin thioesterase 10; deubiquitinating enzyme 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10; MGC2621; |
Gene ID : | 9100 |
mRNA Refseq : | NM_005153 |
Protein Refseq : | NP_005144 |
MIM : | 609818 |
UniProt ID : | Q14694 |
Products Types
◆ Recombinant Protein | ||
USP10-01H | Recombinant Human USP10 Protein, GST-tagged | +Inquiry |
USP10-0546H | Recombinant Human USP10 Protein (A2-L798), Tag Free | +Inquiry |
USP10-0545H | Recombinant Human USP10 Protein (A2-L798), GST tagged | +Inquiry |
USP10-9947M | Recombinant Mouse USP10 Protein, His (Fc)-Avi-tagged | +Inquiry |
USP10-0547H | Recombinant Human USP10 Protein (M1-E480), His/Strep tagged | +Inquiry |
◆ Lysates | ||
USP10-474HCL | Recombinant Human USP10 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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