VPS29
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Official Full Name
vacuolar protein sorting 29 homolog (S. cerevisiae)
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Background
This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene. -
Synonyms
VPS29; vacuolar protein sorting 29 homolog (S. cerevisiae); vacuolar protein sorting 29 (yeast homolog) , vacuolar protein sorting 29 (yeast); vacuolar protein sorting-associated protein 29; DC7; DC15; PEP11; DKFZp564F0223; FLJ20492; hVPS29; PEP11 homolog; Retromer protein; Vacuolar protein sorting 29; Vacuolar protein sorting 29 (yeast homolog); Vacuolar protein sorting 29 (yeast); Vacuolar protein sorting 29 homolog; Vacuolar protein sorting associated protein 29; Vacuolar sorting protein VPS29/PEP11; Vesicle protein sorting 29; VPS 29; VPS29_HUMAN; x 007 protein;
- Involved Pathway
- Protein Function
- Interacting Protein
VPS29 involved in several pathways and played different roles in them. We selected most pathways VPS29 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS29 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ACAP2;ARAP3;D6WSU116E;SNX6;IL2RA;DAB2;VPS45;SH3GLB1A;RAB11BA |
VPS29 has several biochemical functions, for example, metal ion binding, protein binding, contributes_to protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS29 itself. We selected most functions VPS29 had, and list some proteins which have the same functions with VPS29. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | DPF2L;ZFP11;CYP2K6;PGM2L1;GTF2H3;NT5C2;AMY1B;ZNF599;GALNT13 |
| protein binding | ALKBH3;EPO;DDX6;NOL12;NUP62;SYNJ2;MATR3;TLX2;GTF2H2C |
| contributes_to protein transporter activity | DNAJC15;TOMM5;VPS29;DNAJC19 |
| zinc ion binding | PHRF1;LHX4;OAS1;TRIM52;TRPS1;ADH8A;BAZ1A;TRIM35-34;ZFAND2A |
VPS29 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS29 here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS29.
Vps26b; Vps26a; Ywhae; Pgls; Vps35
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