Vacuolar Protein Sorting Protein 29

• Cat.No.: CBCRY38

Specification

• Cat. No.: CBCRY38
• Background: VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.
• Protein Classification: cytoplasmic protein
• Structure Weight: 20531.90 Da
• Polymer: 1
• Molecule: Vacuolar Protein Sorting Protein 29
• Chain Length: 182 amino acids
• PDB ID: 1W24
• MMDB ID: 32322
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 2.10Å
• Reference: Wang, D., Guo, M., Liang, Z., Fan, J., Zhu, Z., Zang, J., Zhu, Z., Li, X., Teng, M., Niu, L., Dong, Y., Liu, P. (2005) Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites. J.Biol.Chem. 280: 22962

Gene Information

• Gene Name: VPS29
• Synonyms: DC15; DC7; DKFZp564F0223; FLJ20492; PEP11; retromer protein; vacuolar protein sorting 29; vacuolar sorting protein VPS29/PEP11; x 007 protein; EC 3.1.3.3; hVPS29; vesicle protein sorting 29
• UniProt ID: Q9UBQ0
• Gene ID: 51699
• Chromosome Location: 12q24
• Function: zinc ion binding; hydrolase activity; metal ion binding