WAS

  • Official Full Name

    Wiskott-Aldrich syndrome
  • Overview

    The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5 UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008]
  • Synonyms

    WAS;Wiskott-Aldrich syndrome;THC;IMD2;SCNX;THC1;WASP;wiskott-Aldrich syndrome protein;eczema-thrombocytopenia;thrombocytopenia 1 (X-linked)

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Bacteria
  • HEK293
  • Mammalian Cells
  • His
  • GST
  • T7
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
  • Flag

    Involved Pathway

    WAS involved in several pathways and played different roles in them. We selected most pathways WAS participated on our site, such as Chemokine signaling pathway,Endocytosis,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with WAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of Actin Cytoskeleton FGFR3,ARPC5L,PDGFA,MSN,ARHGEF7A,PAK3,FGFR2,MYL2B,CDC42L,EZRB
    Bacterial invasion of epithelial cells SEPT2,PIK3CD,MAD2L2,PIK3R1,SRC,CAV3,DNM2,PIK3R2,SEPT11,WASF2
    Chemokine signaling pathway SHC3,CXCL3,ARRB2,CCL28,CXCL2,STAT5B,AKT2,PXN,CXCL14,GRK4
    Salmonella infection MAPK12,ROCK2,CDC42,TLR4,MAPK14A,IL6,IFNG1-2,MAPK9,DYNC1I2A,MAPK10
    Shigellosis DIAPH1,MAD2L2,PFN1,IL-8,CD44,ROCK1,VCL,ELMO1,RAC1,WASF1
    Pathogenic Escherichia coli infection CDH1,TUBA4A,TUBB1,NCK1,PRKCA,NCK2,EZR,NCL,HCLS1,TUBB7P
    Adherens junction MET,ACTN3,ACP1,RAC2,LMO7,ACTN2B,PTPRM,WASLB,CSNK2B,VCLA
    Choline metabolism in cancer TSC1,TSC2,MAPK8,EGF,PIP5K1A,PLA2G4F,RAC3,DGKB,SLC44A1,DGKQ
    Endocytosis CBLB,ARF3B,CXCR2,RHOAA,WASB,DNM1A,D6WSU116E,ASAP3,EPN2,HSP70

    Protein Function

    WAS has several biochemical functions, for example, GTPase regulator activity,SH3 domain binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WAS itself. We selected most functions WAS had, and list some proteins which have the same functions with WAS. You can find most of the proteins on our site.

    Function Related Protein
    GTPase regulator activity ARL2BP,GPSM2,TSC1,TSC1A,RGS12,RUNDC3A,TSC1B,RGS12B,WASL,GPSM1B
    identical protein binding DNM1L,SSNA1,KHDC1B,TPRG1L,DYNLT3,CLDN9,VWA2,ATG101,BCAT1,MLL1
    protein kinase binding USP37,BCL10,SHC1,SPRED2,NCS1,PLK1S1,CACNB4,CDK5RAP2,CNTLN,PTPN23
    SH3 domain binding ELMO3,CBL,WIPF3,GPX1,EPS15,DNM2,SH3BP5,ADAM9,PTTG2,MICAL1
    phospholipase binding CALM,CALM2,PARK2,LMNB1,ARHGAP6,PTPN11,DGKQ,PRKCZ,SNCA,PDPK1
    protein binding DCD,MED11,HSD17B8,FRMD6,ATG13,KLK5,ZNF599,MAPK9,CCNB1,BCL7A
    actin binding CORO2B,SYNE2,MYH7,MYH4,TMOD2,HIP1RB,PARK2,MYH1,TBCCD1,ACTN3A

    Interacting Protein

    WAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WAS here. Most of them are supplied by our site. Hope this information will be useful for your research of WAS.

    CDC42;WIPF1

    WAS Related Signal Pathway

    Resources

    Research Area

    References

    • Jahandar, H; Vaziri, B; et al. Effect of Cysteamine on Cell Growth and IgG(4) Production in Recombinant Sp2.0 Cells. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH 14:177-187(2015).
    • Al-Bahrani, R; Tuertcher, D; et al. Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:3-9(2015).

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