WNT7A
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Official Full Name
wingless-type MMTV integration site family, member 7A -
Overview
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. -
Synonyms
WNT7A;wingless-type MMTV integration site family, member 7A;protein Wnt-7a;proto oncogene Wnt7a protein;proto-oncogene Wnt7a protein;px;tw;Wnt-7a;AI849442
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- HEK293
- CHO
- Mammalian Cells
- E.coli
- Non
- His
- Avi
- Fc
- Myc
Involved Pathway
WNT7A involved in several pathways and played different roles in them. We selected most pathways WNT7A participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | RAC2,PPP3CCB,CSNK1A1L,AXIN2,PRICKLE2B,NFATC3,TBL1X,VANGL1,MAP3K7,DKK2 |
| HTLV-I infection | TCF3,EP300,CRTC3,GSK3B,STAT5A,CANX,ANAPC4,WNT5B,ICAM1,TP53 |
| Hippo signaling pathway | BMP6,BMP2,AJUBA,PPP2CB,SMAD7,FZD10,GDF6,WNT2,WNT7B,TP73 |
| Proteoglycans in cancer | CCND1,PRKACB,PIK3CG,HOXD10,WNT9A,FGFR1,MET,CAMK2D,NUDT16L1,RPS6KB1 |
| Pathways in cancer | VEGFA,MAPK10,FGF17,GNB3,GNG11,GNAS,TP53,GNG4,VEGFB,TRAF4 |
| Melanogenesis | WNT2BB,KRAS,NRAS,CREB3L1,GNAQ,CALM2,FZD5,TYRP1B,a,GNA11A |
| Hedgehog signaling pathway | GLI1,WNT2B,SKIA,IHH,CSNK1G2B,CSNK1DA,GLI3,PRKACG,CSNK1G3,FBXW11B |
| Signaling pathways regulating pluripotency of stem cells | HRAS,PIK3R3,PIK3CD,LEFTY2,ZIC3,WNT8B,NODAL,SMAD5,PAX6,SMAD2 |
| Basal cell carcinoma | HHIP,WNT2B,WNT11,WNT3,WNT2,GLI1,APC2,TCF7,WNT8B,FZD1 |
Protein Function
WNT7A has several biochemical functions, for example, cytokine activity,frizzled binding,receptor agonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT7A itself. We selected most functions WNT7A had, and list some proteins which have the same functions with WNT7A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | GREM2,TNF,IL12BA,Kitl,LTB,IL7,IL37,IL28A,Fasl,NRG1 |
| receptor agonist activity | WNT1,GREM1,WNT8A,NODAL,WNT10B,VEGFA,CXCL13,WNT3A,WNT3,WNT5A |
| receptor binding | EHHADH,ICOSLG,INSL3,HCST,CXADR,CADM1A,HAO2,SRI,F7,C1QTNF2 |
| frizzled binding | WNT3,WNT5A,FZD7,WNT1,WNT8A,LRP6,NDP,WNT9B,FZD1,MYOC |
Interacting Protein
WNT7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT7A here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT7A.
WIF1;STRN4
WNT7A Related Signal Pathway
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References
- Tsai, HL; Deng, WP; et al. Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways. PLOS ONE 9:-(2014).
- Yamada, T; Hasegawa, S; et al. Wnt/beta-Catenin and Kit Signaling Sequentially Regulate Melanocyte Stem Cell Differentiation in UVB-Induced Epidermal Pigmentation. JOURNAL OF INVESTIGATIVE DERMATOLOGY 133:2753-2762(2013).
