akr1c4
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  • Official Full Name
  • aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
  • Background
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
  • Synonyms
  • AKR1C4; aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4); CHDR; aldo-keto reductase family 1 member C4; 3 alpha HSD; C11; CDR; DD4; HAKRA; MGC22581; 3-alpha-HSD1; di
Cat.#:AKR1C4-29344THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C4, His-tagged
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Cat.#:AKR1C4-1006HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C4 protein, His-tagged
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Cat.#:AKR1C4-177HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C4 Protein, His-tagged
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Cat.#:AKR1C4-218HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C4, His-tagged
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Cat.#:AKR1C4-414HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKR1C4 Protein, GST-tagged
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Cat.#:AKR1C4-721HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C4
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Cat.#:AKR1C4-9534HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C4, GST-tagged
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Cat.#:AKR1C4-294RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKR1C4 Protein, His-tagged
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Cat.#:AKR1C4-8929HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AKR1C4 293 Cell Lysate
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Involved Pathway

AKR1C4 involved in several pathways and played different roles in them. We selected most pathways AKR1C4 participated on our site, such as Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Benzo(a)pyrene metabolism
CYP1A1; AKR1C2; CYP3A4; AKR1A1; AKR1C4; CYP1B1; FAM84B
Bile acid and bile salt metabolism
CYP27A1; AKR1C6; CYP7A1; NCOA2; ACOT8; SLCO1B1; CYP46A1; SLC27A2A; SLC27A2; SLC27A5
Metabolic pathways
PON3; BST1; ITPKB; Atp5k; SDHDA; GMPPAB; GGT6; Nat3; CYP1A; UGP2
Metabolism
UGT1B7; PDPR; PROZA; CIAO1; ABHD4; EBP; PAICS; LBR; DUT; VAPB
Metabolism of lipids and lipoproteins
SLC25A1A; SIN3B; MED21; LBR; GLTPA; APOEB; LMF1; ARV1; NFYAL; TPTE
Metabolism of xenobiotics by cytochrome P450
ADH2-2; ADH2-1; GSTK1; PRKRA; AKR1C2; CYP2S1; CYP2F1; AKR1C4
Primary bile acid biosynthesis
CH25HL2; SCP2; CYP46A1; CYP7B1; CYP39A1; SLC27A5; CYP46A1.2; CYP46A1.3; AMACR; CH25H
Retinoid metabolism and transport
BCO2L; APOA4A; AKR1C21; APOA4B.2; RBP2A; AKR1C6; APOM; LRP10; BCO2A; RBP4

Protein Function

AKR1C4 has several biochemical functions, for example, aldo-keto reductase (NADP) activity, androsterone dehydrogenase activity, bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C4 itself. We selected most functions AKR1C4 had, and list some proteins which have the same functions with AKR1C4. You can find most of the proteins on our site.
Function
Related Protein
Function aldo-keto reductase (NADP) activity
Related Protein SDR42E1; CYB5A; AKR1C4; MIOX; AKR1B1; HSD3B6; H2-KE6; KCNAB2; AKR7A3; AKR1C6
Function androsterone dehydrogenase activity
Related Protein AKR1C4; AKR1C6; AKR1C21; AKR1C3
Function bile acid transmembrane transporter activity
Related Protein SLCO1D1; SLCO1A5; SLCO1F2; SLCO1F3; SLCO1C1; SLCO1F1; AKR1C4; SLCO1B3; SLCO1B1; SLCO1A4
Function chlordecone reductase activity
Related Protein AKR1C4
Function electron carrier activity
Related Protein ACAD11; HAAO; SH3BGRL3; ACOX1; AIFM1; NCF2; P4HA2; COX11; GSR; COX7A2A
Function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Related Protein CBR1; AKR1C6; AKR1C4; DHRS4; AKR1C3; DCXR; AKR1C21; AKR1C2; NDUFS7
Function retinal dehydrogenase activity
Related Protein AKR1C6; ALDH8A1; ALDH1A3; ALDH1A1; AKR1C3; AKR1B10; Aldh1a7; AKR1C4; AKR1B8