• Official Full Name
  • aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
  • Background
  • The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.
  • Synonyms
  • AKR1D1; aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); SRD5B1; 3-oxo-5-beta-steroid 4-dehydrogenase; 3o5bred; AK1D1_HUMAN; aldo keto reductase family 1 member D1 (delta 4 3 ketosteroid 5 beta reductase); Aldo keto reductase family 1 member D1; Aldo-keto reductase family 1 member D1; CBAS2; Delta(4) 3 ketosteroid 5 beta reductase; Delta(4) 3 oxosteroid 5 beta reductase; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase; steroid 5 beta reductasebeta polypeptide 1 (3 oxo 5 beta steroid delta 4 dehydrogenase beta 1); steroid 5 beta reductase; OTTHUMP00000208643; OTTHUMP00000208644; OTTHUMP00000208645; steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydro
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1D1 protein
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1D1 protein, His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKR1D1 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AKR1D1 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKR1D1 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AKR1D1
Source (Host):Species:Human
Product nameRecombinant Human AKR1D1 293 Cell Lysate

Involved Pathway

AKR1D1 involved in several pathways and played different roles in them. We selected most pathways AKR1D1 participated on our site, such as Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Primary bile acid biosynthesis
CYP46A1; BRSK2; CH25HL2; CYP7B1; HSD3B7; SCP2; ACOX2; BAAT; SLC27A5; CYP46A1.2
Steroid hormone biosynthesis
CYP2C54; SRD5A1; SRD5A2; CYP2C39; HSD17B1; SRD5A2B; SULT2B1; UGT1A2; CYP19A1A; HSD11B2
Metabolic pathways

Protein Function

AKR1D1 has several biochemical functions, for example, delta4-3-oxosteroid 5beta-reductase activity, steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1D1 itself. We selected most functions AKR1D1 had, and list some proteins which have the same functions with AKR1D1. You can find most of the proteins on our site.
Related Protein
Function delta4-3-oxosteroid 5beta-reductase activity
Related Protein AKR1D1; AKR1C3
Function steroid binding
Related Protein PAQR5A; PGR; PAQR7; CYP21A1; HSD17B10; SULT1E1; PGRMC2; CYP3A4; ESRRA; HSD3B4

AKR1D1 Related Articles

Yanagi, T; Mizuochi, T; et al. Distinguishing primary from secondary Delta(4)-3-oxosteroid 5 beta-reductase (SRD5B1, AKR1D1) deficiency by urinary steroid analysis. CLINICAL ENDOCRINOLOGY 82:346-351(2015).
Yang, F; He, YQ; et al. All-trans retinoic acid regulates hepatic bile acid homeostasis. BIOCHEMICAL PHARMACOLOGY 91:483-489(2014).