ANGPT4
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Official Full Name
angiopoietin 4
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Overview
Angiopoietins 3 (Ang-3); is a secretory protein1 and a ligands of Tie-2 receptor tyrosine kinase.2 Ang3 is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine.1 It inhibits endothelial cell proliferation and survival and blo -
Synonyms
ANGPT4; angiopoietin 4; angiopoietin-4; ANG-3; ANG-4; angiopoietin 3; angiopoietin-3; Ang3; Agpt4; MGC156453;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- Human Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ANGPT4 Related Articles
- ANGPT4 Related Research Area
ANGPT4 involved in several pathways and played different roles in them. We selected most pathways ANGPT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | FGF8;RIN1;FGF21;PLA2G10;FGF18;PLA2G4D;MAPK3;GNG8;RRAS2 |
Rap signaling pathway | RAPGEF6;MET;MAPK11;LPAR2;ITGB1;CALML3;MAP2K6;BRAF;FGF5 |
HIF- signaling pathway | IGF1R;IL6R;EP300;INS1;TF;PLCG1;PIK3R2;ENO3;EIF4E2 |
PIK-Akt signaling pathway | THBS2;IL2RB;FGF14;FIGF;FGFR2;OSMR;COL6A5;IGF1;FGF17 |
ANGPT4 has several biochemical functions, for example, receptor tyrosine kinase binding, transmembrane receptor protein tyrosine kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPT4 itself. We selected most functions ANGPT4 had, and list some proteins which have the same functions with ANGPT4. You can find most of the proteins on our site.
Function | Related Protein |
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receptor tyrosine kinase binding | PLCG1;ELMO2;PTPN11;LRP4;PIK3R2;ZFP259;NCK1;PTPN1;TP53 |
transmembrane receptor protein tyrosine kinase activator activity | NRG3;EGF;NRG1;EFNA5;GREM1;ANGPT4 |
ANGPT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPT4.
daap-5; TEK
- Q&As
- Reviews
Q&As (17)
Ask a questionYes, Angpt4 has been linked to obesity and adipose tissue metabolism. It has been shown to be expressed in adipose tissue and plays a role in adipogenesis (the formation of fat cells) and adipocyte differentiation. Studies have demonstrated that Angpt4 levels are increased in obesity and metabolic disorders, suggesting its involvement in adipose tissue dysfunction and metabolic disturbances.
Research efforts have explored the diagnostic and prognostic potential of Angpt4 protein in various diseases. For example, in cancer, increased expression of Angpt4 has been correlated with poor prognosis and advanced disease stages. In cardiovascular diseases, higher Angpt4 levels have been associated with increased risk and severity of atherosclerosis. However, further studies are needed to establish its clinical utility as a biomarker.
Yes, Angpt4 has been implicated in cardiovascular disorders, such as atherosclerosis, which is characterized by the buildup of plaque in the arterial walls. Studies have shown that Angpt4 is involved in the regulation of vascular permeability and inflammation, which are important processes in atherosclerosis development. Its dysregulation can contribute to the progression of cardiovascular diseases.
While current research primarily focuses on cancer and cardiovascular disorders, there is growing interest in exploring the therapeutic potential of targeting Angpt4 in other diseases. This includes metabolic disorders, such as obesity and diabetes, as well as inflammatory conditions and neurodegenerative diseases. The exact role of Angpt4 in these diseases is still being investigated, but it holds promise as a potential therapeutic target in diverse pathologies.
The expression of Angpt4 protein is regulated by multiple factors, including growth factors, hormones, and cytokines. For example, vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) can upregulate Angpt4 expression. Additionally, transcription factors like HIF-1 (hypoxia-inducible factor-1) can influence the expression of Angpt4 in response to low oxygen levels.
As of now, there are limited clinical trials specifically targeting Angpt4 protein. However, there are clinical trials investigating the effectiveness of anti-angiogenic therapies that may indirectly affect Angpt4. These therapies aim to inhibit the formation of new blood vessels in tumors and are being tested in various cancer types. It is possible that future clinical trials may focus on specifically targeting Angpt4 to further assess its therapeutic potential.
Although there are no specific inhibitors or activators of Angpt4 approved for clinical use currently, research studies have identified potential molecules that can modulate Angpt4 activity. For example, one study showed that a compound called L1-7 can block Angpt4-induced endothelial cell migration and angiogenesis in vitro. Further research is needed to explore the therapeutic potential of these molecules.
As of now, there are no registered clinical trials specifically targeting Angpt4 protein. However, several studies are investigating the role of Angpt4 in different diseases, including cancer, cardiovascular disorders, and metabolic disorders. These studies aim to understand the potential therapeutic implications of targeting Angpt4 in these conditions.
Currently, there are limited reports of genetic mutations or alterations in Angpt4 directly associated with diseases. However, variations in the regulatory regions or expression levels of Angpt4 may contribute to disease susceptibility or severity. Further research is needed to explore the genetic aspects of Angpt4 and its potential implications in various diseases.
Currently, there is limited research on natural compounds or herbal extracts specifically targeting Angpt4 activity. However, natural compounds and herbal extracts are being studied for their potential angiogenic and anti-angiogenic effects, which indirectly may influence Angpt4 activity.
While there is limited research on Angpt4 specifically in wound healing, studies have suggested its involvement in the process. Angpt4 has been found to promote lymphatic vessel growth, and lymphatic vessels play a crucial role in wound healing by draining excess fluid and immune cells from the site of injury.
Gene therapy is a promising approach for targeting specific genes and their associated proteins, and it is possible to consider Angpt4 as a target for gene therapy. However, research on gene therapy specifically targeting Angpt4 is still limited. Gene therapy approaches could involve using viral vectors to introduce therapeutic genes that can modulate Angpt4 expression or using gene editing techniques to alter the genetic sequence of Angpt4. These approaches would require further investigation and testing to assess their feasibility and safety.
While there are no FDA-approved drugs targeting Angpt4, several research efforts are underway to develop therapies that can modulate Angpt4 activity. These include antibodies that can neutralize Angpt4 or inhibit its binding to its receptors. Additionally, small molecule inhibitors that can selectively block Angpt4 signaling are also being explored. These potential therapies are still in preclinical stages and would require further testing before their clinical use.
Angpt4 protein has been implicated in various physiological and pathological processes. It plays a significant role in embryonic development, particularly in angiogenesis and lymphangiogenesis. Additionally, abnormal expression or dysregulation of Angpt4 has been associated with several diseases, including cancer, cardiovascular disorders, and metabolic disorders such as obesity and diabetes.
Although there is ongoing research exploring the potential of Angpt4 as a diagnostic marker, it is not currently widely used for diagnostic purposes. However, there have been studies indicating its possible association with certain diseases. For example, elevated levels of Angpt4 have been found in patients with obesity and metabolic disorders, suggesting its potential as a biomarker in these conditions.
In addition to its role in angiogenesis, Angpt4 has been implicated in lymphangiogenesis, the formation of new lymphatic vessels. It has been shown to promote lymphatic vessel growth and regulate lymphatic endothelial cell function. Angpt4 is also involved in the regulation of endothelial cell permeability and inflammation, which are important in vascular integrity and immune responses. Further research is needed to fully understand the multifaceted functions of Angpt4.
Current research aims to delve deeper into the mechanisms of action and regulation of Angpt4 protein. Scientists are investigating its interactions with other angiogenic factors and signaling pathways to better understand its role in angiogenesis, lymphangiogenesis, and disease processes. Additionally, preclinical studies exploring the therapeutic potential of targeting Angpt4 in various diseases are ongoing to assess its efficacy and safety.
Customer Reviews (5)
Write a reviewTheir expertise and dedication enable them to effectively address and resolve any technical issues that may arise during experimentation.
It can be seamlessly integrated into various molecular biology techniques, such as immunoassays, cell-based functional assays, and protein-protein interaction studies.
Its adaptability enables researchers to unravel the complex interplay and functional relevance of Angpt4 in different biological processes.
The prompt and precise support provided by the manufacturer ensures that researchers can proceed with their work smoothly, without any hindrances or uncertainties.
With the Angpt4 protein as a research tool, achieving meaningful scientific findings becomes an accessible and achievable goal.
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