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ANGPT4

  • Official Full Name

    angiopoietin 4

  • Overview

    Angiopoietins 3 (Ang-3); is a secretory protein1 and a ligands of Tie-2 receptor tyrosine kinase.2 Ang3 is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine.1 It inhibits endothelial cell proliferation and survival and blo
  • Synonyms

    ANGPT4; angiopoietin 4; angiopoietin-4; ANG-3; ANG-4; angiopoietin 3; angiopoietin-3; Ang3; Agpt4; MGC156453;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANGPT4-1587H Recombinant Human Angiopoietin 4 Mammalian cells N/A
Human ANGPT4-750H Recombinant Human ANGPT4 protein, His & GST-tagged E.coli His/GST Tyr305~Ile503 (Accession # Q9Y264)
Human ANGPT4-207H Recombinant Human ANGPT4 Protein, Fc-tagged HEK293 Fc
Human ANGPT4-208H Recombinant Human ANGPT4 Protein, His-tagged HEK293 His
Human ANGPT4-552H Recombinant Human ANGPT4 protein, GST-tagged Wheat Germ GST
Human ANGPT4-1318HCL Recombinant Human ANGPT4 cell lysate Human Cell N/A
Human ANGPT4-1614HCL Recombinant Human ANGPT4 cell lysate Human Cell N/A
Human ANGPT4-005H Active Recombinant Human ANGPT4 Protein E. coli
Human ANGPT4-4362H-B Recombinant Human ANGPT4 Protein Pre-coupled Magnetic Beads HEK293
Human ANGPT4-0113H Recombinant Human ANGPT4 Protein (Tyr305-Ile503), N-GST-tagged E.coli N-GST Tyr305-Ile503
Human ANGPT4-4362H Recombinant Human ANGPT4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Angpt4-2519M Recombinant Mouse Angiopoietin 4 Mammalian cells N/A
Mouse Angpt4-751M Recombinant Mouse Angpt4 protein, His & GST-tagged E.coli His/GST Phe32~Pro144
Mouse Angpt4-10520M-B Recombinant Mouse Angpt4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Angpt4-10520M Recombinant Mouse Angpt4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Angpt4-752R Recombinant Rat Angpt4 protein, His & T7-tagged E.coli His/T7 Arg272~Phe489 (Accession # D3ZR43)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANGPT4 Related Articles
  • ANGPT4 Related Research Area

ANGPT4 involved in several pathways and played different roles in them. We selected most pathways ANGPT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayFGF8;RIN1;FGF21;PLA2G10;FGF18;PLA2G4D;MAPK3;GNG8;RRAS2
Rap signaling pathwayRAPGEF6;MET;MAPK11;LPAR2;ITGB1;CALML3;MAP2K6;BRAF;FGF5
HIF- signaling pathwayIGF1R;IL6R;EP300;INS1;TF;PLCG1;PIK3R2;ENO3;EIF4E2
PIK-Akt signaling pathwayTHBS2;IL2RB;FGF14;FIGF;FGFR2;OSMR;COL6A5;IGF1;FGF17

ANGPT4 has several biochemical functions, for example, receptor tyrosine kinase binding, transmembrane receptor protein tyrosine kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPT4 itself. We selected most functions ANGPT4 had, and list some proteins which have the same functions with ANGPT4. You can find most of the proteins on our site.

Function Related Protein
receptor tyrosine kinase bindingPLCG1;ELMO2;PTPN11;LRP4;PIK3R2;ZFP259;NCK1;PTPN1;TP53
transmembrane receptor protein tyrosine kinase activator activityNRG3;EGF;NRG1;EFNA5;GREM1;ANGPT4

ANGPT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPT4.

daap-5; TEK

Li, L; Chong, HC; et al. Angiopoietin-like 4 Increases Pulmonary Tissue Leakiness and Damage during Influenza Pneumonia. CELL REPORTS 10:654-663(2015).
Kaneko, K; Tsuji, S; et al. Pathogenesis of childhood idiopathic nephrotic syndrome: a paradigm shift from T-cells to podocytes. WORLD JOURNAL OF PEDIATRICS 11:21-28(2015).
  • Q&As
  • Reviews

Q&As (17)

Ask a question
Is there a connection between Angpt4 and obesity? 03/09/2023

Yes, Angpt4 has been linked to obesity and adipose tissue metabolism. It has been shown to be expressed in adipose tissue and plays a role in adipogenesis (the formation of fat cells) and adipocyte differentiation. Studies have demonstrated that Angpt4 levels are increased in obesity and metabolic disorders, suggesting its involvement in adipose tissue dysfunction and metabolic disturbances.

Does Angpt4 protein have any diagnostic or prognostic value in diseases? 05/11/2022

Research efforts have explored the diagnostic and prognostic potential of Angpt4 protein in various diseases. For example, in cancer, increased expression of Angpt4 has been correlated with poor prognosis and advanced disease stages. In cardiovascular diseases, higher Angpt4 levels have been associated with increased risk and severity of atherosclerosis. However, further studies are needed to establish its clinical utility as a biomarker.

Does Angpt4 have any role in cardiovascular disorders? 11/17/2021

Yes, Angpt4 has been implicated in cardiovascular disorders, such as atherosclerosis, which is characterized by the buildup of plaque in the arterial walls. Studies have shown that Angpt4 is involved in the regulation of vascular permeability and inflammation, which are important processes in atherosclerosis development. Its dysregulation can contribute to the progression of cardiovascular diseases.

Can Angpt4 be used as a therapeutic target in other diseases besides cancer and cardiovascular disorders? 09/16/2021

While current research primarily focuses on cancer and cardiovascular disorders, there is growing interest in exploring the therapeutic potential of targeting Angpt4 in other diseases. This includes metabolic disorders, such as obesity and diabetes, as well as inflammatory conditions and neurodegenerative diseases. The exact role of Angpt4 in these diseases is still being investigated, but it holds promise as a potential therapeutic target in diverse pathologies.

How is the expression of Angpt4 regulated? 05/18/2021

The expression of Angpt4 protein is regulated by multiple factors, including growth factors, hormones, and cytokines. For example, vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) can upregulate Angpt4 expression. Additionally, transcription factors like HIF-1 (hypoxia-inducible factor-1) can influence the expression of Angpt4 in response to low oxygen levels.

Are there any ongoing clinical trials targeting Angpt4 protein? 04/22/2021

As of now, there are limited clinical trials specifically targeting Angpt4 protein. However, there are clinical trials investigating the effectiveness of anti-angiogenic therapies that may indirectly affect Angpt4. These therapies aim to inhibit the formation of new blood vessels in tumors and are being tested in various cancer types. It is possible that future clinical trials may focus on specifically targeting Angpt4 to further assess its therapeutic potential.

Are there any known inhibitors or activators of Angpt4 protein? 02/28/2021

Although there are no specific inhibitors or activators of Angpt4 approved for clinical use currently, research studies have identified potential molecules that can modulate Angpt4 activity. For example, one study showed that a compound called L1-7 can block Angpt4-induced endothelial cell migration and angiogenesis in vitro. Further research is needed to explore the therapeutic potential of these molecules.

Are there any ongoing clinical trials targeting Angpt4 protein? 01/27/2021

As of now, there are no registered clinical trials specifically targeting Angpt4 protein. However, several studies are investigating the role of Angpt4 in different diseases, including cancer, cardiovascular disorders, and metabolic disorders. These studies aim to understand the potential therapeutic implications of targeting Angpt4 in these conditions.

Are there any known genetic mutations or alterations in Angpt4 associated with diseases? 01/12/2021

Currently, there are limited reports of genetic mutations or alterations in Angpt4 directly associated with diseases. However, variations in the regulatory regions or expression levels of Angpt4 may contribute to disease susceptibility or severity. Further research is needed to explore the genetic aspects of Angpt4 and its potential implications in various diseases.

Are there any natural compounds or herbal extracts that can modulate Angpt4 activity? 12/03/2020

Currently, there is limited research on natural compounds or herbal extracts specifically targeting Angpt4 activity. However, natural compounds and herbal extracts are being studied for their potential angiogenic and anti-angiogenic effects, which indirectly may influence Angpt4 activity.

Are there any studies investigating the potential role of Angpt4 in wound healing? 11/16/2020

While there is limited research on Angpt4 specifically in wound healing, studies have suggested its involvement in the process. Angpt4 has been found to promote lymphatic vessel growth, and lymphatic vessels play a crucial role in wound healing by draining excess fluid and immune cells from the site of injury.

Can Angpt4 be targeted for therapeutic purposes using gene therapy? 01/02/2020

Gene therapy is a promising approach for targeting specific genes and their associated proteins, and it is possible to consider Angpt4 as a target for gene therapy. However, research on gene therapy specifically targeting Angpt4 is still limited. Gene therapy approaches could involve using viral vectors to introduce therapeutic genes that can modulate Angpt4 expression or using gene editing techniques to alter the genetic sequence of Angpt4. These approaches would require further investigation and testing to assess their feasibility and safety.

Are there any drugs or therapies targeting Angpt4 currently in development? 05/05/2019

While there are no FDA-approved drugs targeting Angpt4, several research efforts are underway to develop therapies that can modulate Angpt4 activity. These include antibodies that can neutralize Angpt4 or inhibit its binding to its receptors. Additionally, small molecule inhibitors that can selectively block Angpt4 signaling are also being explored. These potential therapies are still in preclinical stages and would require further testing before their clinical use.

What are the potential roles of Angpt4 protein in disease or health conditions? 03/21/2019

Angpt4 protein has been implicated in various physiological and pathological processes. It plays a significant role in embryonic development, particularly in angiogenesis and lymphangiogenesis. Additionally, abnormal expression or dysregulation of Angpt4 has been associated with several diseases, including cancer, cardiovascular disorders, and metabolic disorders such as obesity and diabetes.

Can Angpt4 be used as a diagnostic marker for certain diseases? 07/18/2018

Although there is ongoing research exploring the potential of Angpt4 as a diagnostic marker, it is not currently widely used for diagnostic purposes. However, there have been studies indicating its possible association with certain diseases. For example, elevated levels of Angpt4 have been found in patients with obesity and metabolic disorders, suggesting its potential as a biomarker in these conditions.

What are the other functions of Angpt4 protein besides its angiogenic role? 04/03/2016

In addition to its role in angiogenesis, Angpt4 has been implicated in lymphangiogenesis, the formation of new lymphatic vessels. It has been shown to promote lymphatic vessel growth and regulate lymphatic endothelial cell function. Angpt4 is also involved in the regulation of endothelial cell permeability and inflammation, which are important in vascular integrity and immune responses. Further research is needed to fully understand the multifaceted functions of Angpt4.

What research is being done to further understand Angpt4 protein? 01/10/2016

Current research aims to delve deeper into the mechanisms of action and regulation of Angpt4 protein. Scientists are investigating its interactions with other angiogenic factors and signaling pathways to better understand its role in angiogenesis, lymphangiogenesis, and disease processes. Additionally, preclinical studies exploring the therapeutic potential of targeting Angpt4 in various diseases are ongoing to assess its efficacy and safety.

Customer Reviews (5)

Write a review
Reviews
08/21/2019

    Their expertise and dedication enable them to effectively address and resolve any technical issues that may arise during experimentation.

    06/20/2019

      It can be seamlessly integrated into various molecular biology techniques, such as immunoassays, cell-based functional assays, and protein-protein interaction studies.

      03/24/2018

        Its adaptability enables researchers to unravel the complex interplay and functional relevance of Angpt4 in different biological processes.

        05/10/2016

          The prompt and precise support provided by the manufacturer ensures that researchers can proceed with their work smoothly, without any hindrances or uncertainties.

          04/25/2016

            With the Angpt4 protein as a research tool, achieving meaningful scientific findings becomes an accessible and achievable goal.

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