Recombinant Human Angiopoietin 4
| Cat.No. : | ANGPT4-1587H |
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| Species : | Human |
| Source : | Mammalian Cells |
| Tag : | Non |
| Protein Length : | 23-503 aa |
| Description : | shares 45%, 47% and 54% aa sequence identity with human Ang-1, human Ang-2 and mouse Ang-3, respectively. Although the sequence homology is much higher between the human and mouse counterparts for Ang-1 (97%) and Ang-2 (85%), mouse Ang-3 is believed to be an ortholog of human Ang-4 based on chromosomal localization studies. Human Ang-4 is highly expressed in lung and in cultured human umbilical vein endothelial cells (HUVECs). In contrast, mouse Ang-3 is expressed multiple mouse tissues. Human Ang-4 is an agonist that can bind and activate Tie-2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Mouse Ang-3 has been reported to be a Tie-2 antagonist. It is likely that mouse Ang-3, like Ang-2, may exert agonist or antagonist activities depending on the cell context. |
| State Of Matter : | Lyophilized. |
| Purity : | >85% by SDS PAGE and analyzed by silver stain. |
| Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
| Molecular Weight : | The predicted molecular weight of Recombinant Human Ang-4 is Mr 57 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-100 kDa. |
| Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Gene Name | ANGPT4 angiopoietin 4 [ Homo sapiens ] |
| Synonyms | angiopoietin 4; AGP4; ANG4; ANG-3; MGC138181; MGC138183; ANGPT4; angiopoietin-3; dJ824F16.2 (angiopoietin 4); ANG-4; ANG3; OTTHUMP00000029947 |
| Gene ID | 51378 |
| mRNA Refseq | NM_015985 |
| Protein Refseq | NP_057069 |
| MIM | 603705 |
| UniProt ID | Q9Y264 |
| Chromosome Location | 20p13 |
| Pathway | Hemostasis; Signaling in Immune system |
| Function | transmembrane receptor protein tyrosine kinase activator activity; receptor binding |
Not For Human Consumption!
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