ap3m1
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  • Official Full Name
  • adaptor-related protein complex 3, mu 1 subunit
  • Background
  • The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed.
  • Synonyms
  • AP3M1; adaptor-related protein complex 3, mu 1 subunit; AP-3 complex subunit mu-1; Adapter-related protein complex 3 mu-1 subunit; AP-3 adapter complex mu3A subunit; AP3M1_HUMAN; CLATHRIN ADAPTOR COMPLEX AP3; Mu-adaptin 3A; mu3A; Mu3A-adaptin; clathrin adaptor complex AP3, mu-3A subunit
Cat.#:AP3M1-657HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AP3M1 protein, GST-tagged
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Cat.#:AP3M1-9722HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AP3M1, GST-tagged
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Cat.#:AP3M1-1746MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AP3M1 Protein
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Cat.#:Ap3m1-3541RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ap3m1, His-tagged
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Cat.#:AP3M1-2889CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AP3M1
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Cat.#:AP3M1-11440ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AP3M1
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Involved Pathway

AP3M1 involved in several pathways and played different roles in them. We selected most pathways AP3M1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP3M1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lysosome
CTSE; AP4E1; CTSH; AP3D1; ARSG; TCIRG1; ACP5; LIPA; ASAH1A; ARSA

Protein Function

AP3M1 has several biochemical functions, for example, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP3M1 itself. We selected most functions AP3M1 had, and list some proteins which have the same functions with AP3M1. You can find most of the proteins on our site.
Function
Related Protein
Function Rab GTPase binding
Related Protein TBC1D7; ULK1; RAB11FIP2; RABGAP1; RABGEF1; CHML; ALS2; ATP6AP1; ODF2; MICAL1
Function protein binding
Related Protein SALL4; FGFR1; GLP1R; PDE3B; F11R; RFPL4; SH3BP1; HNRNPA2B1; MAGI1; RTF1

Interacting Protein

AP3M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP3M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP3M1.
CRMP1; AGTRAP; TRIM9; SIPA1L2; RSPH14; WDR48; mnmC; pi3p