ARHGAP11A
-
Official Full Name
Rho GTPase activating protein 11A
-
Synonyms
ARHGAP11A; Rho GTPase activating protein 11A; rho GTPase-activating protein 11A; GAP (1 12); KIAA0013; GAP (1-12); rho-type GTPase-activating protein 11A; MGC70740;
- Recombinant Proteins
- Chicken
- Human
- Zebrafish
- E.coli
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ARHGAP11A-9813H | Recombinant Human ARHGAP11A, His-tagged | E.coli | His | C-term-369a.a. | |
Human | ARHGAP11A-760H | Recombinant Human ARHGAP11A protein, GST-tagged | Wheat Germ | GST | ||
Human | ARHGAP11A-1146HF | Recombinant Full Length Human ARHGAP11A Protein, GST-tagged | In Vitro Cell Free System | GST | 501 amino acids | |
Zebrafish | ARHGAP11A-12503Z | Recombinant Zebrafish ARHGAP11A | Mammalian Cell | His | ||
Zebrafish | ARHGAP11A-7787Z | Recombinant Zebrafish ARHGAP11A | Mammalian Cell | His | ||
Chicken | ARHGAP11A-1618C | Recombinant Chicken ARHGAP11A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGAP11A involved in several pathways and played different roles in them. We selected most pathways ARHGAP11A participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Rho GTPase cycle | NET1;ARHGAP17A;ARAP1;CHN1;ARHGEF3;ARHGAP18;ARHGAP40;RHOF;ARHGAP17B |
Signal Transduction | DZIP1;ARHGEF3;UTS2;C;ARHGAP40;RBP4;CDC42EP3;ZFPM2B;KREMEN1 |
Signaling by Rho GTPases | FAM13A;GDI2;TAGAPA;RHOT2;ARHGAP12B;ARHGAP26;FMNL2;TAX1BP3;STARD8 |
ARHGAP11A has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP11A itself. We selected most functions ARHGAP11A had, and list some proteins which have the same functions with ARHGAP11A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
GTPase activator activity | STARD8;DLC1;RGS21;ASAP1;ARHGAP12;ARHGEF6;GDI1;CDC42EP1B;BNIP2 |
ARHGAP11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP11A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP11A.
SFN; MYO1C; FLNA; MYH9; Vps4b; IQGAP1; CAPZA2; Tpm1; Actb; PPP1CB; DBN1; Flot2; Kif5b; Myh10; SYNPO; Myh9; MYO18A
- Q&As
- Reviews
Q&As (20)
Ask a questionMicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate gene expression. Although specific miRNAs targeting ARHGAP11A have not been extensively documented, some miRNAs, such as miR-17-5p and miR-429, have been reported to interact with ARHGAP11A in certain contexts. These miRNAs may modulate ARHGAP11A expression levels, but further studies are needed to fully understand the regulatory interactions between miRNAs and ARHGAP11A.
ARHGAP11A is expressed in various cell types, including epithelial cells, fibroblasts, neurons, and immune cells. Its expression pattern suggests that it has diverse functions in different cell contexts.
Yes, ARHGAP11A exhibits differential expression patterns in different tissues. It is expressed in various tissues and cell types, including the brain, heart, liver, and immune cells. The levels of ARHGAP11A expression can vary depending on the tissue and the developmental stage. For example, ARHGAP11A is highly expressed in the brain, particularly in regions involved in learning and memory processes. However, tissue-specific expression patterns and their functional significance require further investigation.
Limited research has suggested a potential role for ARHGAP11A in immune responses. It has been implicated in the regulation of immune cell migration and adhesion, as well as inflammatory signaling pathways. However, further studies are needed to fully understand its involvement in immune responses.
While specific genetic or epigenetic factors that directly influence ARHGAP11A expression are not well-established, it is possible that mutations or epigenetic modifications in the regulatory regions of the ARHGAP11A gene could alter its expression levels. Further research is needed to fully understand the regulatory mechanisms governing ARHGAP11A expression.
There is limited information regarding the use of ARHGAP11A as a biomarker for specific diseases. However, altered expression or genetic variations in ARHGAP11A have been observed in certain diseases, such as cancer and neurodevelopmental disorders. These findings suggest that ARHGAP11A may have potential as a biomarker for disease prognosis or diagnostic purposes. Nonetheless, more research is needed to establish its clinical utility as a biomarker.
While specific diseases linked to ARHGAP11A mutations are currently not well-established, dysregulation of ARHGAP11A has been observed in certain cancers, suggesting a potential role in cancer progression. Further research is needed to explore its involvement in other diseases or disorders.
Yes, ARHGAP11A has been implicated in neuronal development and neuronal migration. It is involved in regulating the cytoskeletal dynamics required for proper neuron migration during brain development.
ARHGAP11A promotes cell migration by inhibiting the activity of RhoA, a Rho GTPase that suppresses cell motility. By inactivating RhoA, ARHGAP11A allows for cytoskeletal remodeling and cell movement.
Yes, ARHGAP11A is involved in neuronal development and function. It has been shown to play a role in axon guidance and neuronal migration during brain development. Furthermore, ARHGAP11A has been linked to synaptic plasticity and cognitive function, making it a relevant protein in the context of neurodevelopmental disorders.
Yes, ARHGAP11A has been reported to interact with several proteins involved in cellular signaling and cytoskeletal dynamics. For example, it can associate with Rho GTPases, such as RhoA and Rac1, to regulate their activity. ARHGAP11A has also been shown to interact with actin-binding proteins, such as cortactin, which may help mediate its effects on cytoskeletal remodeling.
Yes, ARHGAP11A contains several functional domains, including a RhoGAP domain. The RhoGAP domain is responsible for its ability to inactivate Rho GTPases by promoting the hydrolysis of GTP to GDP, thereby regulating their signaling.
There have been reports of genetic variations, including single nucleotide polymorphisms (SNPs), in the ARHGAP11A gene. Some studies have associated certain SNPs in ARHGAP11A with increased risk for neurodevelopmental disorders, while others have identified variations in ARHGAP11A as potential biomarkers for cancer prognosis. However, more research is required to determine the functional significance of these genetic variations.
Yes, ARHGAP11A has several isoforms and splice variants resulting from alternative splicing of its mRNA. These isoforms may have distinct functions or subcellular localizations.
As of now, there are no specific drugs or compounds that directly target ARHGAP11A. However, since ARHGAP11A regulates Rho GTPases, compounds that modulate Rho GTPase activity, such as Rho GTPase inhibitors or activators, may indirectly affect ARHGAP11A's function. Additionally, further research on ARHGAP11A biology may identify potential therapeutic targets or strategies for diseases associated with its dysfunction.
Currently, there are no specific drugs or therapeutic approaches targeting ARHGAP11A. However, understanding its role in cancer and other diseases could potentially lead to the development of targeted therapies in the future.
ARHGAP11A protein is primarily localized to the cytoplasm of cells, where it interacts with various cellular components and mediates its functions. However, it can also translocate to the nucleus in response to specific signaling events or interactions with other proteins.
While not extensively studied, ARHGAP11A dysfunction has been associated with certain diseases and disorders. For instance, mutations or dysregulation of ARHGAP11A have been implicated in developmental disorders, such as intellectual disability and autism spectrum disorder. Additionally, altered expression of ARHGAP11A has been observed in various cancers, suggesting a potential role in disease progression.
Yes, ARHGAP11A has been implicated in cancer progression. It can act either as a tumor suppressor or a tumor promoter, depending on the context and cancer type. For example, ARHGAP11A has been found to inhibit cell migration and invasion in breast cancer, while promoting cell proliferation and metastasis in liver cancer. Its role in cancer is still being actively studied.
Yes, several proteins have been identified as interacting partners of ARHGAP11A. These include other Rho GTPases, such as RhoA, Rac1, and Cdc42, as well as various cytoskeletal proteins and scaffold proteins involved in signaling pathways. Interactions with these proteins contribute to the regulation of ARHGAP11A's functions.
Customer Reviews (8)
Write a reviewThe manufacturer of ARHGAP11A protein has consistently provided outstanding technical support that has surpassed my expectations.
Their dedication to customer satisfaction has been instrumental in overcoming obstacles and achieving successful results in my experiments.
This variety allows me to select the most appropriate option based on the specific requirements of my research.
the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the ARHGAP11A protein, which is essential for obtaining accurate and consistent results.
I am delighted to express my complete satisfaction with the quality of ARHGAP11A protein, as it precisely suits my experimental requirements.
This protein demonstrates remarkable purity, stability, and specificity, ensuring utmost accuracy and reproducibility in my research endeavors.
With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.
Their expertise in protein production and purification ensures the delivery of a high-quality product that consistently performs well in my experiments.
Ask a Question for All ARHGAP11A Products
Required fields are marked with *
My Review for All ARHGAP11A Products
Required fields are marked with *