| Description : |
This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. [provided by RefSeq, Sep 2016] |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
81.51 kDa |
| AA Sequence : |
MWDQRLVRLALLQHLRAFYGIKVKG VRGQCDRRRHETAATEIGGKIFGVP FNALPHSAVPEYGHIPSFLVDACTS LEDHIHTEGLFRKSGSVIRLKALKN KVDHGEGCLSSAPPCDIAGLLKQFF RELPEPILPADLHEALLKAQQLGTE EKNKATLLLSCLLADHTVHVLRYFF NFLRNVSLRSSENKMDSSNLAVIFA PNLLQTSEGHEKMSSNTEKKLRLQA AVVQTLIDYASDIGRVPDFILEKIP AMLGIDGLCATPSLEGFEEGEYETP GEYKRKRRQSVGDFVSGALNKFKPN RTPSITPQEERIAQLSESPVILTPN AKRTLPVDSSHGFSSKKRKSIKHNF NFELLPSNLFNSSSTPVSVHIDTSS EGSSQSSLSPVLIGGNHLITAGVPR RSKRIAGKKVCRVESGKAGCFSPKI SHKEKVRRSLRLKFNLGKNGREVNG CSGVNRYESVGWRLANQQSLKNRIE SVKTGLLFSPDVDEKLPKKGTFTYY C |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
