ARL2BP Protein, ADP-ribosylation factor-like 2 binding protein

ARL2BP

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ARL2BP

Official Full Name ADP-ribosylation factor-like 2 binding protein
Background ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.
Synonyms ARL2BP; ADP-ribosylation factor-like 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein; BART; BART1; binder of Arl2; ADP ribosylation factor like 2 binding protein; Arf like 2 binding protein BART1; ARL2BP protein; Binder of Arl Two; binder of ARF2 protein 1; ARF-like 2-binding protein; Arf-like 2 binding protein BART1
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARL2BP-2878H Recombinant Human ARL2BP, His-tagged E.coli His
    Human ARL2BP-453H Recombinant Human ARL2BP, His tagged E.coli Fc/His
    Human ARL2BP-6904H Recombinant Human ADP-Ribosylation Factor-Like 2 Binding Protein, His-tagged E.coli His
    Human ARL2BP-809H Recombinant Human ARL2BP protein, GST-tagged Wheat Germ GST
    Human ARL2BP-8715HCL Recombinant Human ARL2BP 293 Cell Lysate HEK293 N/A
    Human ARL2BP-9855H Recombinant Human ARL2BP, GST-tagged E.coli GST
    Mouse ARL2BP-1929M Recombinant Mouse ARL2BP Protein Mammalian Cell His
    Rat ARL2BP-781R Recombinant Rat ARL2BP Protein Mammalian Cell His
    Cynomolgus Monkey ARL2BP-311C Recombinant Cynomolgus ARL2BP Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ARL2BP-400R Recombinant Rhesus monkey ARL2BP Protein, His-tagged Mammalian Cell His
    Chicken ARL2BP-1814C Recombinant Chicken ARL2BP Mammalian Cell His
    Zebrafish ARL2BP-11234Z Recombinant Zebrafish ARL2BP Mammalian Cell His

    ARL2BP involved in several pathways and played different roles in them. We selected most pathways ARL2BP participated on our site, such as Integration of energy metabolism, Metabolism, Regulation of insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARL2BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integration of energy metabolism AKAP5; ARL2; MARCKSB; MARCKSA; ARL2BP; KCNJ11; GNG13A; RAPGEF4; KCNB1; KCNC2
    Metabolism ALDH9A1A.2; CYP2D6; KCNJ11; OMD; SREBF2; UGT1B4; MED18; SULT1C2; NDUFAF4; GLRX
    Regulation of insulin secretion KCNS3A; ARL2BP; KCNC2; ARL2; MARCKSA; KCNS3; KCNB1; SYT5; MARCKSB

    ARL2BP has several biochemical functions, for example, GTPase regulator activity, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARL2BP itself. We selected most functions ARL2BP had, and list some proteins which have the same functions with ARL2BP. You can find most of the proteins on our site.

    Function Related Protein
    GTPase regulator activity RGS12B; PCP2; KRIT1; TSC1; RGS14A; ARL2BP; RHPN1; RGS12; RUNDC3A; WASL
    protein binding DHH; IDE; MT1F; CCNL2; LNPEP; FUCA2; ERLIN1; SH2D4A; GPR37L1; TBCA
    transcription coactivator activity TAF7; NEUROG3; CREBBP; GMEB1; ARID1A; RAP2C; RUNX1; PCBD1; NCOA4; KLF7

    ARL2BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARL2BP here. Most of them are supplied by our site. Hope this information will be useful for your research of ARL2BP.

    ARL2; RAC1; MPP3; CAMK2D

    Davidson, AE; Schwarz, N; et al. Mutations in ARL2BP, Encoding ADP-Ribosylation-Factor-Like 2 Binding Protein, Cause Autosomal-Recessive Retinitis Pigmentosa. AMERICAN JOURNAL OF HUMAN GENETICS 93:321-329(2013).
    Zhou, Y; Jiang, H; et al. MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells. CELL DEATH & DISEASE 4:-(2013).

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