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Official Full Name ATPase, Na+/K+ transporting, alpha 2 polypeptide
Background The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
Synonyms ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide , MHP2, migraine, hemiplegic 2; sodium/potassium-transporting ATPase subunit alpha-2; FHM2; KIAA0778; Na+/K+ATPase alpha 2 subunit; AT1A2_HUMAN; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; sodium-potassium ATPase; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; sodium/potassium-transporting ATPase alpha-2 chain
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP1A2-366H Recombinant Human ATP1A2 protein, GST-tagged E. coli GST
    Human ATP1A2-10005H Recombinant Human ATP1A2, His-tagged E.coli His
    Human ATP1A2-365H Recombinant Human ATP1A2 Mammalian Cell His
    Human ATP1A2-8612HCL Recombinant Human ATP1A2 293 Cell Lysate HEK293 N/A
    Rat ATP1A2-853R Recombinant Rat ATP1A2 Protein Mammalian Cell His
    Rhesus Macaque ATP1A2-447R Recombinant Rhesus monkey ATP1A2 Protein, His-tagged Mammalian Cell His
    Chicken ATP1A2-7025C Recombinant Chicken ATP1A2 Mammalian Cell His

    ATP1A2 involved in several pathways and played different roles in them. We selected most pathways ATP1A2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway INS; VDAC1; GATA4; AKT2; ATP1A2; NFATC4; GUCY1A3; PLCB3; CALML3; TRPC6
    cAMP signaling pathway HCN4; FXYD2; PIK3R1; FSHR; PIK3R2; HCAR3; PIK3CD; HCAR2; PLD2; PDE4C
    Cardiac muscle contraction ATP2A2; UQCRC2A; FXYD2; CACNB4A; MYL3; CACNG7; TPM3; CACNG3; COX6B1; TNNC1
    Adrenergic signaling in cardiomyocytes PRKACG; CALM3; MAPK11; MAPK14A; CAMK2G; AKT2; CACNG2A; SLC8A1; PIK3R3B; ATF4B1
    Insulin secretion KCNMB1; PLCB4; GIP; ATP1B2; CCKAR; KCNN4; CREB3L3; VAMP2; KCNMB4; SLC2A2
    Thyroid hormone synthesis GPX6; GPX2; PRKCB; ATF4; Adcy4; TPO; CREB3L1; PLCB2; ATP1B1; LRP2
    Thyroid hormone signaling pathway SLC16A2; THRA; PIK3R3; PRKCB; ATP2A2; MED4; RHEB; ATP1B2; MED1; HIF1A
    Aldosterone-regulated sodium reabsorption PRKCB; ATP1A1; INS; PRKCA; ATP1B2; INSR; IGF1; ATP1B4; NEDD4L; ATP1A2
    Endocrine and other factor-regulated calcium reabsorption KLK2; ATP1A1; KLK1B24; PLCB1; ATP1B3; DNM3; PRKCB; ATP1A3; KLK1B9; KLK1B11
    Proximal tubule bicarbonate reclamation GLS2; CA2; SLC9A3; ATP1A3; GLS; ATP1A2; AQP1; MDH1; ATP1B3; GLUD1
    Salivary secretion PRH1; ATP1B3; CAP18; PRKCG; DMBT1; KCNN4; ATP1A3; PMAP-36; RYR3; AMY1A
    Gastric acid secretion KCNJ2; ATP1B1; ATP1A3; ATP1A2; CCKBR; GNAI3; CALM3; PRKACG; Slc4a2; CAMK2D
    Pancreatic secretion ATP1A2; SCTR; ATP1B4; RAB3D; SLC9A1; PLA2G2E; PLA2G1B; BST1; GNAQ; CD38
    Carbohydrate digestion and absorption AMY2A5; ATP1A1; PRKCB; ATP1B2; PIK3R5; PLCB2; G6PC3; ATP1A3; AMY1A; HK1
    Protein digestion and absorption KCNK5; SLC15A1; CPB1; COL6A5; COL18A1; SLC7A8; MEP1A; ATP1A1; SLC16A10; CPA3
    Bile secretion SULT2A1; ABCG2; SLCO1B1; ABCG8; Car2; ABCC2; SLC9A1; SLCO1A6; CFTR; ADCY6
    Mineral absorption ATP7A; S100G; ATP1B1; MT2; MT1G; MT1B; SLC26A6; STEAP2; MT1A; SLC11A1

    ATP1A2 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A2 itself. We selected most functions ATP1A2 had, and list some proteins which have the same functions with ATP1A2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ATP binding SFRP5; MSH6; ATP1B1; MSH2; ATP5D; ATP1A2; ABCG8
    contributes_to ATPase activity ABCA7; ATP5O; PPP2R4; ATP5J2; ATP5C1; ATP5A1; ABCG8; ATP1B1; MSH2; ATP5E
    chaperone binding ERP29; TBCD; DNAJC3; GRPEL1; HYOU1; DNAJA2L; CLU; UBL4; UBL4A; GET4
    contributes_to drug binding PGGT1B; ATP1A2; ATP1B1
    contributes_to potassium ion binding ATP1B1; ATP1A2
    protein binding CATSPERG2; CCDC92; SYTL2; RASSF3; USP28; LNX2B; FLG; ADAMTS3; RBP5; CEBPG
    contributes_to sodium ion binding ATP1B1; ATP1A2
    sodium:potassium-exchanging ATPase activity ATP1A1A.3; ATP4A; ATP12A; ATP1A1A.1; ATP1A2; ATP1A4; ATP1A3B; ATP1B3; ATP1A1A.5; FXYD2
    contributes_to sodium:potassium-exchanging ATPase activity ATP1B1; ATP1B2; ATP1B3; ATP1A1; ATP1A2
    steroid hormone binding GPR30; ATP1A2; ESR2A; ATP1A1; ATP1A3; ESR2B; NR3C1

    ATP1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A2.


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