ATP1A2 Protein, ATPase, Na+/K+ transporting, alpha 2 polypeptide


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Official Full Name ATPase, Na+/K+ transporting, alpha 2 polypeptide
Background The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
Synonyms ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide , MHP2, migraine, hemiplegic 2; sodium/potassium-transporting ATPase subunit alpha-2; FHM2; KIAA0778; Na+/K+ATPase alpha 2 subunit; AT1A2_HUMAN; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; sodium-potassium ATPase; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; sodium/potassium-transporting ATPase alpha-2 chain
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP1A2-10005H Recombinant Human ATP1A2, His-tagged E.coli His
    Human ATP1A2-365H Recombinant Human ATP1A2 Mammalian Cell His
    Human ATP1A2-8612HCL Recombinant Human ATP1A2 293 Cell Lysate HEK293 N/A
    Rat ATP1A2-853R Recombinant Rat ATP1A2 Protein Mammalian Cell His
    Rhesus Macaque ATP1A2-447R Recombinant Rhesus monkey ATP1A2 Protein, His-tagged Mammalian Cell His
    Chicken ATP1A2-7025C Recombinant Chicken ATP1A2 Mammalian Cell His

    ATP1A2 involved in several pathways and played different roles in them. We selected most pathways ATP1A2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway ROCK1; GNAI2; CALM2; AKT1; PLN; MYLK; MAP2K1; VDAC3; CREB3L1; ITPR1
    cAMP signaling pathway CALM3; PIK3R2; CREB3L1; HTR1B; VAV1; PIK3CA; GRIN3A; CALML5; GPR81; ATP1B2
    Cardiac muscle contraction CACNB4A; CACNB1; TPM3; MYL2; VMHC; TNNT2; CACNA1SA; CACNG1; COX7C; CACNA2D4
    Adrenergic signaling in cardiomyocytes SCN5A; GNAI2A; ADRB3B; GNAS; CACNA1C; ADCY8; GNAI3; TPM2; ADRB2A; CACNB2
    Insulin secretion INS2; VAMP2; RYR2; GLP1R; ATP1B4; ATP1A3; KCNMB3; KCNJ11; CAMK2A; FFAR1
    Thyroid hormone synthesis CREB3L1; IYD; PRKACG; SLC5A5; PLCB2; GPX5; PDIA4; PLCB3; FXYD2; PRKCB
    Thyroid hormone signaling pathway PRKACG; PIK3R1; ATP2A2; PFKP; RCAN2; PRKCA; MED1; AKT2; TP53; PFKFB2
    Aldosterone-regulated sodium reabsorption MAPK1; FXYD4; NEDD4L; FXYD2; PIK3R1; IRS1; SFN; NR3C2; ATP1B3; ATP1B2
    Endocrine and other factor-regulated calcium reabsorption KL; PLCB3; RAB11A; PRKACG; ATP1B4; ATP1A4; KLK1B11; PRKCA; KLK1B8; KLK2
    Proximal tubule bicarbonate reclamation ATP1B1; Car2; ATP1A1; SLC9A3; SLC25A10; Car4; PCK1; AQP1; GLS; CA4
    Salivary secretion CALM1; Slc4a2; TRPV6; VAMP2; PLCB4; SLC9A1; LYZ2; AMY1A; GNAS; CAMP
    Gastric acid secretion MYLK; HRH2; ATP1A2; GNAI2; CALML3; SLC9A1; KCNJ1; PRKACG; ATP4B; CAMK2A
    Pancreatic secretion ATP1A3; Adcy4; SCTR; ATP2A1; ATP1B2; CLCA1; RAP1B; CPA3; CA2; ITPR3
    Carbohydrate digestion and absorption HK1; PIK3CG; ATP1B4; AMY2A3; ATP1A4; AMY2A2; HKDC1; G6PC3; AKT1; ATP1A2
    Protein digestion and absorption DPP4; SLC7A8; PRSS1; ATP1A2; CPB2; CPA3; COL6A6; SLC8A2; ATP1A4; FXYD2
    Bile secretion OSTB; ATP1A4; ABCB4; ADCY9; SLC5A1; CYP7A1; ABCB1; SLC51A; ADCY6; HMGCR
    Mineral absorption TF; SLC34A2; ATP1A2; MT2; ATP1A4; SLC26A9; SLC46A1; Trf; ATP1B3; MT1

    ATP1A2 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A2 itself. We selected most functions ATP1A2 had, and list some proteins which have the same functions with ATP1A2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ATP binding MSH2; MSH6; SFRP5; ATP1B1; ABCG8; ATP1A2; ATP5D
    contributes_to ATPase activity MSH6; PPP2R4; ATP5C1; ATP5A1; RFC3; ATP5B; ABCA7; ATP1B1; SFRP5; ATP5L
    chaperone binding AMFR; GRPEL2; CALR; HLA-B; BIRC5; DNAJB4; BAG2; PACRG; DNAJA2; CDC37L1
    contributes_to drug binding ATP1B1; ATP1A2; PGGT1B
    contributes_to potassium ion binding ATP1B1; ATP1A2
    protein binding KIAA0247; CLK1; DHX58; THG1L; KATNAL1; CYC1; CLIP1; STATH; MGST3; RHOH
    contributes_to sodium ion binding ATP1A2; ATP1B1
    sodium:potassium-exchanging ATPase activity ATP1A4; ATP4A; ATP1A1A.3; ATP1A1A.1; ATP12A; ATP1A2A; ATP1A3A; ATP1A1B; ATP1B3; ATP1A1A.4
    contributes_to sodium:potassium-exchanging ATPase activity ATP1A2; ATP1B2; ATP1A1; ATP1B3; ATP1B1
    steroid hormone binding ESR2A; ATP1A2; ATP1A1; GPR30; ESR2B; ATP1A3; NR3C1

    ATP1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A2.


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