• Official Full Name
  • beta-carotene 15,15-monooxygenase 1
  • Background
  • Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules.
  • Synonyms
  • BCMO1; beta-carotene 15,15-monooxygenase 1; BCDO, BCDO1, beta carotene 15, 15 dioxygenase 1; beta,beta-carotene 15,15-monooxygenase; BCMO; FLJ10730; beta-carotene dioxygenase 1; beta-carotene 15, 15-dioxygenase 1; BCO; BCDO; BCO1; BCDO1
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCMO1 Protein, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCMO1, His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCMO1 Protein, GST-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCMO1 Protein, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human BCMO1 protein, MYC/DDK-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BCMO1 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BCMO1
Source (Host):Species:Human
Product nameRecombinant Human BCMO1 293 Cell Lysate

Involved Pathway

BCMO1 involved in several pathways and played different roles in them. We selected most pathways BCMO1 participated on our site, such as Retinol metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCMO1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Retinol metabolism
SDR16C5; DHRS3B; BCO1; CYP2C50; CYP2A12; CYP2C18; UGT1A9; ADH2-2; UGT1A7C; DGAT1
Metabolic pathways

Protein Function

BCMO1 has several biochemical functions, for example, beta-carotene 15,15-monooxygenase activity, metal ion binding, monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCMO1 itself. We selected most functions BCMO1 had, and list some proteins which have the same functions with BCMO1. You can find most of the proteins on our site.
Related Protein
Function beta-carotene 15,15-monooxygenase activity
Related Protein BCMO1; BCO1
Function metal ion binding
Related Protein ZEB2A; PKM; MAP3K15; HRG; ROCK2; NLN; ADAMTS12; FTH1B; PPM1G; PAPD7
Function monooxygenase activity
Related Protein CYP1C1; CYP4A10; CYP2AA4; CYP1D1; CYP2C18; YWHAQB; CYP51; CYP2C8; CYP2C54; CYP1A2

Interacting Protein

BCMO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCMO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCMO1.

BCMO1 Related Articles

Zubair, N; Kooperberg, C; et al. Genetic Variation Predicts Serum Lycopene Concentrations in a Multiethnic Population of Postmenopausal Women. JOURNAL OF NUTRITION 145:187-192(2015).
Yamaguchi, N; Sunto, A; et al. Competitive regulation of human intestinal beta-carotene 15,15 '-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1 alpha and HNF-4 alpha. LIFE SCIENCES 119:34-39(2014).