• Official Full Name
  • block of proliferation 1
  • Background
  • Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene.It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle.It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans.Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.
  • Synonyms
  • BOP1; block of proliferation 1; ribosome biogenesis protein BOP1; KIAA0124; AU020183; AW146150; Block of proliferation 1 protein; Bop1 block of proliferation 1; BOP1_HUMAN; D18861; Erb1p; MGC109114; mKIAA0124; OTTHUMP00000228465
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BOP1 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BOP1 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BOP1 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BOP1
Source (Host):Species:Human
Product nameRecombinant Human BOP1 293 Cell Lysate

Protein Function

BOP1 has several biochemical functions, for example, poly(A) RNA binding, protein binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BOP1 itself. We selected most functions BOP1 had, and list some proteins which have the same functions with BOP1. You can find most of the proteins on our site.
Related Protein
Function poly(A) RNA binding
Related Protein YTHDF2; BUD13; ASS1; EIF1B; MRPS31; DDX47; NSBP1; ILF3; NSUN5; SRP14
Function protein binding
Related Protein MED8; APLF; PSMD10; UBE2D3; MAPRE3; RTN1; KRTAP19-5; TMEM41A; SNX18; DOCK1
Function ribonucleoprotein complex binding
Related Protein PITX2; PRMT5; PES; PPIH; PRPF31; UHMK1; CD2BP2; PQBP1; RNF135; ITCH

Interacting Protein

BOP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BOP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BOP1.
PES1; WDR12; b4dyc6_human; ARRB2; ARRB1; WDR48; NUDC; KLF10; NPM1; MNDA; IFI16; PELP1; WDR18; SENP3