carm1
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  • Official Full Name
  • coactivator-associated arginine methyltransferase 1
  • Background
  • Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from;S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine;derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction,;metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)).
  • Synonyms
  • CARM1; coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; PRMT4; protein arginine N-methyltransferase 4
Cat.#:CARM1-0402HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CARM1 Protein, GST-Tagged
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Cat.#:CARM1-451HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CARM1
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Cat.#:CARM1-617HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human CARM1, His-tagged
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Cat.#:CARM1-176HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CARM1 Protein, GST-tagged
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Cat.#:CARM1-999HTag:His/GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CARM1, Flag-tagged
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Cat.#:Carm1-23MTag:FLAG
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Carm1 Protein, FLAG-tagged
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Cat.#:CARM1-2735MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CARM1 Protein
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Cat.#:CARM1-1139RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CARM1 Protein
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Cat.#:CARM1-1064ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CARM1
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Cat.#:CARM1-7846HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CARM1 293 Cell Lysate
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Involved Pathway

CARM1 involved in several pathways and played different roles in them. We selected most pathways CARM1 participated on our site, such as Activation of gene expression by SREBF (SREBP), Androgen receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of gene expression by SREBF (SREBP)
NCOA2; SREBF2; CARM1; NFYAL; MTF1; CREBBP; NFYBB; DHCR7; PMVK; CYP51A1
Androgen receptor signaling pathway
CTNNB1; NCOA2; SMARCE1; NR0B2A; CCDC102A; KAT5; RAD54L2; RNF4; AES; ETV5A
BMAL1:CLOCK,NPAS2 activates circadian gene expression
DBP; CRY1; NCOA2; NAMPT; CRY2; CARM1; NRIP1; HELZ2; CREBBP
Chromatin modifying enzymes
SMARCA4; BRD8; ELP4; CHD4; MSL2B; KANSL2; ACTL6A; PBRM1L; MORF4L2; GATAD2A
Chromatin organization
TADA3; MSL1A; KAT7A; ARID1A; PRMT6; PRMT7; KDM4B; PBRM1; KDM2B; KDM3B
Circadian Clock
CRY2; HELZ2; CSNK1E; NAMPT; CRY1; NRIP1; DBP; CPT1A; RAI1; CARM1
Coregulation of Androgen receptor activity
CARM1; CMTM2A; KDM3A; PAWR; ZMIZ1; TCF4; KDM1A; MAK; PATZ1; NRIP1
Developmental Biology
CSNK2A2; SPRED1; SPNA1; SPTBN2; MED10; TRPC5; CNTN1; FRS2A; EGR2; FRS2B

Protein Function

CARM1 has several biochemical functions, for example, beta-catenin binding, histone methyltransferase activity, histone methyltransferase activity (H3-R17 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by CARM1 itself. We selected most functions CARM1 had, and list some proteins which have the same functions with CARM1. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein SMAD3; LZTS2A; LEF1; CD2AP; TBL1XR1; DACT2; PXN; CTNNA3; FAM123B; KLF4
Function histone methyltransferase activity
Related Protein PRMT6; PRDM13; PRMT2; EZH2; EED; SUZ12; CARM1; SUV39H1; PRMT1
Function histone methyltransferase activity (H3-R17 specific)
Related Protein CARM1
Function histone-arginine N-methyltransferase activity
Related Protein CARM1; PRMT3; PRMT2; PRMT6; PRMT7; PRMT8; PRMT5
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein CCAR1; PKN1; SFR1; SLC30A9; ENY2; USP22; ACTN4; PPARG; MED1; NCOA2
Function lysine-acetylated histone binding
Related Protein BAZ1B; BRD7; BRD3; TAF1; BRD2; BAZ2A; MLL1; PSME4B; PHIP; CARM1
Function protein binding
Related Protein PRICKLE1A; DIS3L2; SEPT2; SERPINA3; PLK1S1; ELAVL1; EBF1; STON2; TMSB10; RAB4B
Function protein homodimerization activity
Related Protein GOT2; BARD1; PDGFA; DMRT2; DRD2; PAFAH1B1; ACVR1; SYT6; SRR; MID1
Function protein methyltransferase activity
Related Protein METTL7B; METTL21D; PRDM13; PRDM12; CARM1; TRMT112; N6AMT1; RNMTL1B; FAM86; DIMT1
Function protein-arginine N-methyltransferase activity
Related Protein NDUFAF5; PRMT2; METTL21D; PRDM11; DIMT1; PRMT8B; FBXO11; PRDM13; PRMT5; PRMT1
Function protein-arginine omega-N asymmetric methyltransferase activity
Related Protein PRMT1; PRMT6; PRMT8; PRMT2; PRMT3; PRMT7; CARM1; PRMT8B
Function transcription coactivator activity
Related Protein PMF1; TADA1; NRIP1; PRPF6; ARID1A; NR1I3; ABRA; USP22; UTF1; TFAP2A
Function transcription regulatory region DNA binding
Related Protein CEBPA; HIVEP2; IKZF2; PPARG; FOXH1; GRHL2B; CREB3L1; SNCA; ZNF831; GABPA

Interacting Protein

CARM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARM1.
SMARCC1; CEBPB; CEBPB; NUDT21; DNAJA3; QKI; ORF; NRIP1; HNRNPK; UBE2I

CARM1 Related Articles

Zeng, H; Wu, JC; et al. A TR-FRET-Based Functional Assay for Screening Activators of CARM1. CHEMBIOCHEM 14:827-835(2013).
Sakabe, K; Hart, GW; et al. O-GlcNAc Transferase Regulates Mitotic Chromatin Dynamics. JOURNAL OF BIOLOGICAL CHEMISTRY 285:34460-34468(2010).