carm1
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  • Official Full Name
  • coactivator-associated arginine methyltransferase 1
  • Background
  • Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from;S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine;derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction,;metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)).
  • Synonyms
  • CARM1; coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; PRMT4; protein arginine N-methyltransferase 4
Cat.#:CARM1-0402HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CARM1 Protein, GST-Tagged
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Cat.#:CARM1-451HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CARM1
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Cat.#:CARM1-617HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human CARM1, His-tagged
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Cat.#:CARM1-176HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CARM1 Protein, GST-tagged
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Cat.#:CARM1-999HTag:His/GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CARM1, Flag-tagged
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Cat.#:Carm1-23MTag:FLAG
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Carm1 Protein, FLAG-tagged
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Cat.#:CARM1-2735MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CARM1 Protein
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Cat.#:CARM1-1139RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CARM1 Protein
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Cat.#:CARM1-1064ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CARM1
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Cat.#:CARM1-7846HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CARM1 293 Cell Lysate
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Involved Pathway

CARM1 involved in several pathways and played different roles in them. We selected most pathways CARM1 participated on our site, such as Activation of gene expression by SREBF (SREBP), Androgen receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARM1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of gene expression by SREBF (SREBP)
CARM1; CREBBP; DHCR7; MTF1; PMVK; NFYBA; NFYAL; SREBF2; NCOA2; HELZ2
Androgen receptor signaling pathway
POU2F1B; DAXX; PNRC1; CCDC102A; AES; KAT7; ZMIZ1; RNF14; HMGB2A; PATZ1
BMAL1:CLOCK,NPAS2 activates circadian gene expression
NRIP1; NAMPT; DBP; CARM1; CRY1; CREBBP; HELZ2; NCOA2; CRY2
Chromatin modifying enzymes
RBBP5; ATXN7L3; ARID1A; TAF6L; KDM4C; KDM3A; WDR77; SAP18; MTA2; MSL2A
Chromatin organization
SMARCC1B; CAPNS2; SMYD2; CARM1; GATAD2B; BRMS1; PHF8; BRD8; KAT8; ING5
Circadian Clock
RAI1; CSNK1E; CRY1; NRIP1; CRY2; CPT1A; CARM1; DBP; NAMPT; HELZ2
Coregulation of Androgen receptor activity
KDM1A; ZMIZ1; SVIL; CTDSP1; TGFB1I1; SNURF; NRIP1; KDM3A; KDM4C; PIAS3
Developmental Biology
CAP2; KIF4A; AP2B1; COL4A3; ACTR2B; SPRED2; CLTC; CFL1; RGMB; EPHB3A

Protein Function

CARM1 has several biochemical functions, for example, beta-catenin binding, histone methyltransferase activity, histone methyltransferase activity (H3-R17 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by CARM1 itself. We selected most functions CARM1 had, and list some proteins which have the same functions with CARM1. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein SLC9A3R2; HDAC6; CTNNA3; SLC9A3R1; DACT3; SMAD3; SOX17; CDH24; BCL9L; Ar
Function histone methyltransferase activity
Related Protein EED; CARM1; SUV39H1; PRMT2; EZH2; PRMT6; PRMT1; PRDM13; SUZ12
Function histone methyltransferase activity (H3-R17 specific)
Related Protein CARM1
Function histone-arginine N-methyltransferase activity
Related Protein PRMT7; PRMT3; PRMT2; PRMT6; PRMT5; CARM1; PRMT8
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein MED24; SLC30A9; PSMC3IP; PKN1; PPARGC1B; MED1; THRAP3; CARM1; MED17; RBM14
Function lysine-acetylated histone binding
Related Protein BRD3; PSME4; BRD4; BAZ2A; PSME4B; BAZ1B; BRD7; BRD2; TAF1; SMARCA4
Function protein binding
Related Protein TTC3; HOMER3; ZC3H11A; CDKN2D; FGF7; NGF; MYOCD; HSPB1; SARM1; RAB22A
Function protein homodimerization activity
Related Protein DSCAML1; DCK; LILRB1; ABAT; ALDH1A3; TFAP2B; MLL1; LRP4; CER1; VEGFA
Function protein methyltransferase activity
Related Protein RNMTL1A; PRMT1; N6AMT1; PRDM12; METTL21D; PRMT8B; TRMT10C; TRMT112; HEMK1; PRDM13
Function protein-arginine N-methyltransferase activity
Related Protein TRMT10C; CARM1; PRMT2; FBXO11; PRMT1; FBLL1; METTL8; PRDM11; PRMT3; FAM86
Function protein-arginine omega-N asymmetric methyltransferase activity
Related Protein PRMT8B; PRMT6; PRMT1; PRMT2; PRMT7; PRMT8; PRMT3; CARM1
Function transcription coactivator activity
Related Protein SNW1; ARNT; DDX5; TADA3; MYSM1; JMY; TUBB3; UBE2L3; HCFC2; MAGED1
Function transcription regulatory region DNA binding
Related Protein CITED1; BCL11AB; NKX3; CALCOCO1; GATA3; NKX2-5; TP63; WT1; FOXM1; JUN

Interacting Protein

CARM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARM1.
SMARCC1; CEBPB; CEBPB; NUDT21; DNAJA3; QKI; ORF; NRIP1; HNRNPK; UBE2I

CARM1 Related Articles

Zeng, H; Wu, JC; et al. A TR-FRET-Based Functional Assay for Screening Activators of CARM1. CHEMBIOCHEM 14:827-835(2013).
Sakabe, K; Hart, GW; et al. O-GlcNAc Transferase Regulates Mitotic Chromatin Dynamics. JOURNAL OF BIOLOGICAL CHEMISTRY 285:34460-34468(2010).