CARM1

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CARM1

Official Full Name coactivator-associated arginine methyltransferase 1
Background Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from;S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine;derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction,;metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)).
Synonyms CARM1; coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; PRMT4; protein arginine N-methyltransferase 4
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Free Style 293-F Cell
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • FLAG
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CARM1-0402H Recombinant Human CARM1 Protein, GST-Tagged Wheat Germ GST
    Human CARM1-176H Recombinant Human CARM1 Protein, GST-tagged E.coli GST
    Human CARM1-451H Recombinant Human CARM1 Free Style 293-F Cell N/A
    Human CARM1-617H Recombinant Human CARM1, His-tagged Sf21 Insect Cell His
    Human CARM1-7846HCL Recombinant Human CARM1 293 Cell Lysate HEK293 N/A
    Human CARM1-999H Recombinant Human CARM1, Flag-tagged Sf9 Insect Cell His/GST
    Mouse Carm1-23M Recombinant Mouse Carm1 Protein, FLAG-tagged Insect Cell FLAG
    Mouse CARM1-2735M Recombinant Mouse CARM1 Protein Mammalian Cell His
    Rat CARM1-1139R Recombinant Rat CARM1 Protein Mammalian Cell His
    Zebrafish CARM1-1064Z Recombinant Zebrafish CARM1 Mammalian Cell His

    CARM1 involved in several pathways and played different roles in them. We selected most pathways CARM1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of gene expression by SREBF (SREBP) CARM1; PMVK; CREBBP; CYP51A1; SREBF2; DHCR7; NFYAL; HELZ2; NFYBB; NCOA2
    Androgen receptor signaling pathway CTNNB2; NCOA2; PATZ1; PIAS3; CMTM2A; NR2C2; JUN; RAD54L2; PNRC1; AES
    BMAL1:CLOCK,NPAS2 activates circadian gene expression NCOA2; NAMPT; CRY1; CARM1; NRIP1; DBP; CREBBP; CRY2; HELZ2
    Chromatin modifying enzymes PADI1; JMJD6; KAT7A; EP400; EPC1; C17orf81; KAT5; CAPNS2; KAT6B; AEBP2
    Chromatin organization KDM6AL; ATF7IP; SUZ12A; PHF2; SMARCB1A; RBBP4; KAT7A; KDM6B; KANSL3; PADI1
    Circadian Clock NRIP1; CSNK1E; CRY2; CPT1A; NAMPT; RAI1; DBP; CRY1; HELZ2; CARM1
    Coregulation of Androgen receptor activity SNURF; CMTM2A; PIAS3; PAWR; SVIL; CTDSP1; TMF1; NRIP1; ZMIZ1; MAK
    Developmental Biology LGI1A; EFNA5; SPRED1; FGF20A; BOC; IL17RD; PITPNA; DPYSL3; CAP2; COL4A5

    CARM1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CARM1 itself. We selected most functions CARM1 had, and list some proteins which have the same functions with CARM1. You can find most of the proteins on our site.

    Function Related Protein
    beta-catenin binding CDH5; PARK2; Ar; BCL9; PTPRJ; SMAD7; ASH2L; ESR1; KLF4; FAM123B
    histone methyltransferase activity SUV39H1; EZH2; SUZ12; PRMT6; PRMT2; PRDM13; EED; CARM1; PRMT1
    histone methyltransferase activity (H3-R17 specific) CARM1
    histone-arginine N-methyltransferase activity PRMT2; PRMT6; PRMT3; PRMT8; PRMT5; PRMT7; CARM1
    ligand-dependent nuclear receptor transcription coactivator activity DCAF6; PRKCB; SRA1; ZCCHC18; PPARG; MED14; CCAR1; BUD31; CCDC62; CARM1
    lysine-acetylated histone binding PHIP; CARM1; BRD7; BRD9; ATAD2B; BAZ1B; TAF1L; BRD2; TRIM24; TAF1
    protein binding METAP2; CIB3; C1QTNF8; CARKD; RASSF7; MAP3K7; GPM6A; FRMD4B; KEAP1; HGD
    protein homodimerization activity TESC; P2RX7; NPM1; GM5506; SMAD2; SYT6; TFAP2A; TIGIT; YARS2; BHLHE40
    protein methyltransferase activity RNMTL1A; PRDM11; RNMTL1B; METTL21D; PRMT8B; FAM86; PRDM13; PRDM12; HEMK1; TRMT112
    protein-arginine N-methyltransferase activity PRDM12; PRDM11; TRMT10C; PRDM13; PRMT8B; TRMT10B; CARM1; FBLL1; PRMT1; DIMT1
    protein-arginine omega-N asymmetric methyltransferase activity PRMT8B; PRMT7; PRMT8; PRMT3; PRMT2; PRMT6; PRMT1; CARM1
    transcription coactivator activity PRMT2; MAML1; MAK; TADA3; JUND; SMARCA4; NR1I3; JUNB; NR1H4; RNF20
    transcription regulatory region DNA binding CCNT1; ZNF567; SOX7; ZFHX3; GABPB2; RFX3; FOXA2; CREB3L2; ZFP513; TOMM20A

    CARM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARM1.

    SMARCC1; CEBPB; CEBPB; NUDT21; DNAJA3; QKI; ORF; NRIP1; HNRNPK; UBE2I

    Zeng, H; Wu, JC; et al. A TR-FRET-Based Functional Assay for Screening Activators of CARM1. CHEMBIOCHEM 14:827-835(2013).
    Sakabe, K; Hart, GW; et al. O-GlcNAc Transferase Regulates Mitotic Chromatin Dynamics. JOURNAL OF BIOLOGICAL CHEMISTRY 285:34460-34468(2010).

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