ccbl1
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  • Official Full Name
  • cysteine conjugate-beta lyase, cytoplasmic
  • Background
  • This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.
  • Synonyms
  • CCBL1; cysteine conjugate-beta lyase, cytoplasmic; cysteine conjugate beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); kynurenine--oxoglutarate transaminase 1; glutamine transaminase K; GTK; KATI; kyneurenine aminotransferase; CCBL 1; Beta lyase; Beta lysase, kidney; Cysteine conjugate beta lyase, cytoplasmic; Cysteine S conjugate beta lyase; Cytoplasmic cysteine conjugate beta lyase; FLJ95217; Glutamine phenylpyruvate aminotransferase; KAT1; Kynurenine aminotransferase I; Kynurenine oxoglutarate transaminase 1; MGC29624; OTTHUMP00000022311; OTTHUMP00000022312; beta-lysase, kidney; cysteine-S-conjugate beta-lyase; glutamine--phenylpyruvate transaminase; ky
Cat.#:CCBL1-0492HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCBL1 Protein, GST-Tagged
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Cat.#:CCBL1-387HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCBL1, T7-tagged
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Cat.#:CCBL1-82HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCBL1, His-tagged
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Cat.#:CCBL1-1166RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCBL1 Protein
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Cat.#:CCBL1-12539ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCBL1
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Cat.#:CCBL1-7796HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCBL1 293 Cell Lysate
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Involved Pathway

CCBL1 involved in several pathways and played different roles in them. We selected most pathways CCBL1 participated on our site, such as Tryptophan metabolism, Selenocompound metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCBL1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tryptophan metabolism
TDO2B; ALDH2.2; ASMT; ALDH2.1; CMTM2A; TDO2A; HAAO; KYNU; ALDH3A2; RNF25
Selenocompound metabolism
PAPSS2; PAPSS1; CCBL2; SEPHS1; TXNRD3; SCLY; TRR1; MARS; TXNRD2; PAPSS2B
Metabolic pathways
GALNT7; GNS; NAT8L; CEL.1; LDHBB; OCRL; PLA2G2D; ACSS2; POLA1; PYGM
Chemical carcinogenesis
UGT1A1; CYP3A4; UGT1A6B; ADH1C; GSTT1; CCBL1; CYP2C39; UGT2B7; ALDH1A3; CYP3A25

Protein Function

CCBL1 has several biochemical functions, for example, L-glutamine:pyruvate aminotransferase activity, L-phenylalanine:pyruvate aminotransferase activity, cysteine-S-conjugate beta-lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCBL1 itself. We selected most functions CCBL1 had, and list some proteins which have the same functions with CCBL1. You can find most of the proteins on our site.
Function
Related Protein
Function L-glutamine:pyruvate aminotransferase activity
Related Protein CCBL1
Function L-phenylalanine:pyruvate aminotransferase activity
Related Protein CCBL1
Function cysteine-S-conjugate beta-lyase activity
Related Protein CCBL2; CCBL1
Function glutamine-phenylpyruvate transaminase activity
Related Protein CCBL1
Function kynurenine-oxoglutarate transaminase activity
Related Protein CCBL1; AADAT; GOT2; CCBL2
Function protein binding
Related Protein ACHE; PTPRN; SRPK1; PTPRA; H2AFX; CCDC70; CYP4F2; PSMC3; F7; PLEKHG4
Function protein homodimerization activity
Related Protein PVR; HSP90AA1; CHEK2; SHMT1; RAG1; TIMM10; PVRL4; PLDN; GNB2L1; ADRB3
Function pyridoxal phosphate binding
Related Protein SDS; AGXT2L1; GPT2L; HINT2; ALAS2; GOT2; PYGMB; AGXT2; SHMT1; SPTLC3
Function transaminase activity
Related Protein GOT2A; GOT2B; AGXT2; AGXTA; CCBL1; PHYKPL; AGXT2L1; AGXT; GOT1L1; AMT

Interacting Protein

CCBL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCBL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCBL1.
VAC14; TRIP13