Cry1
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Official Full Name
cryptochrome 1 (photolyase-like)
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Overview
Cryptochromes (from the Greek κρυπτ? χρ?μα, hidden colour) are a class of blue light-sensitive flavoproteins found in plants and animals. Cryptochromes are involved in the circadian rhythms of plants and animals, and in the sensing of magnetic fields in a number of species. The name Cryptochrome was proposed as a pun combining the cryptic nature of the photoreceptor, and the cryptogamic organisms on which many blue light studies were carried out. The two genes Cry1 and Cry2 code for the two cryptochrome proteins CRY1 and CRY2. In insects and plants, CRY1 regulates the circadian clock in a light-dependent fashion, whereas in mammals, CRY1 and CRY2 act as light-independent inhibitors of CLOCK-BMAL1 components of the circadian clock. In plants, blue light photoreception can be used to cue developmental signals -
Synonyms
CRY1; cryptochrome 1 (photolyase-like); PHLL1; cryptochrome-1; photolyase-like cryptochrome 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|GST
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Cry1 Related Articles
Cry1 involved in several pathways and played different roles in them. We selected most pathways Cry1 participated on our site, such as BMAL1:CLOCK,NPAS2 activates circadian gene expression, Circadian Clock, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cry1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | CRY1;HELZ2;DBP;NAMPT;NRIP1;CREBBP;CARM1;NCOA2;CRY2 |
| Circadian Clock | DBP;CRY1;CARM1;CRY2;NAMPT;RAI1;CSNK1E;HELZ2;NRIP1 |
| Circadian rhythm | RBX1;PRKAG3;FBXL3;FBXW11;PRKAA2;SKP1;CRY1;CLOCK;CUL1 |
| Diurnally regulated genes with circadian orthologs | ZFR;SF3A3;KLF9;CEBPB;RBPMS;TOB1;QKI;GFRA1;EIF4G2 |
Cry1 has several biochemical functions, for example, NOT DNA (6-4) photolyase activity, DNA binding, blue light photoreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cry1 itself. We selected most functions Cry1 had, and list some proteins which have the same functions with Cry1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT DNA (6-4) photolyase activity | CRY1;CRY2 |
| DNA binding | ZFP580;TAF6L;HMBOX1;SPO11;HIST1H4C;ZIC5;UBN1;ZNF550;SUPV3L1 |
| blue light photoreceptor activity | CRY2;CRY1 |
| core promoter binding | SPI1;HDAC2;IRF9;HDAC4;IFI203;PSPC1;NKX3-1;FOXP3;CCAR1 |
| core promoter sequence-specific DNA binding | SOX1;THRAP3;C1orf51;RORA;NFYA;CRY1;ZFHX3;H2AFY;REST |
| NOT deoxyribodipyrimidine photo-lyase activity | CRY2;CRY1 |
| double-stranded DNA binding | TDG;HMGB2;TARDBP;FEN1;RAD51D;CSDA;DDX11;DMC1;SMAD2 |
| histone deacetylase binding | PHB;CBX5;D7ERTD443E;USF1;RBBP4;NCOR2;HOXA10;HIC1;TRAF6 |
| nuclear hormone receptor binding | HIF1A;MED1;TACC2;CRY1;BUD31;SMARCD3;SIRT1;ACTN4;EP300 |
| nucleotide binding | ATP1A1B;CAMK2D2;TRIOA;IGF2BP3;SMC5;RAVER2;CDC6;RAB18B;HNRNPC |
| phosphatase binding | SLC9A3R2;PPP1R32;CHCHD3;SH2D4A;SYTL2;DLG3;MAST2;ELFN2;SH3YL1 |
| protein binding | FGF3;MYBL2;NEK6;CCR5;PRCC;RCOR1;TSGA10IP;FLT3;SPRR1A |
| protein kinase binding | LSM2;CAV1;CDKN2B;CCNT2A;TENC1;DLG1;AXIN2;THY1;CCNL1B |
| transcription factor activity, transcription factor binding | PER2;ASCL1;ASCL1B;LDB2B;LDB1B;TRP63;HIF1A;LDB2A;FOXO1 |
| transcription factor binding | MAFB;JUNB;RBPJ;PSMD10;NAB2;JUND;SMARCD3;NFATC2;PAXBP1 |
| ubiquitin binding | TOM1L1;FAF2;PER2;VPS28;UBXN2B;NSFL1C;RBCK1;CRY2;DNAJC2 |
Cry1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cry1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cry1.
PLSCR1; CSNK1E; Cry1; Csnk1e; Timeless; GRN; SNRPD3; TRAF2; CBLB; LTBP4; MDFI; KRTAP4-12; Psmb5; SYNCRIP; BAG6; JAK3; Sesn2; Esrrb
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