Recombinant Human CRY1 Protein, GST-tagged

• Cat.No.: CRY1-1922H
• Product Overview: Human CRY1 full-length ORF ( AAH30519, 1 a.a. - 586 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 90.20 kDa
• AA Sequence: MGVNAVHWFRKGLRLHDNPALKECI QGADTIRCVYILDPWFAGSSNVGIN RWRFLLQCLEDLDANLRKLNSRLFV IRGQPADVFPRLFKEWNITKLSIEY DSEPFGKERDAAIKKLATEAGVEVI VRISHTLYDLDKIIELNGGQPPLTY KRFQTLISKMEPLEIPVETITSEVI EKCTTPLSDDHDEKYGVPSLEELGF DTDGLSSAVWPGGETEALTRLERHL ERKAWVANFERPRMNANSLLASPTG LSPYLRFGCLSCRLFYFKLTDLYKK VKKNSSPPLSLYGQLLWREFFYTAA TNNPRFDKMEGNPICVQIPWDKNPE ALAKWAEGRTGFPWIDAIMTQLRQE GWIHHLARHAVACFLTRGDLWISWE EGMKVFEELLLDADWSINAGSWMWL SCSSFFQQFFHCYCPVGFGRRTDPN GDYIRRYLPVLRGFPAKYIYDPWNA PEGIQKVAKCLIGVNYPKPMVNHAE ASRLNIERMKQIYQQLSRYRGLGLL ASVPSNPNGNGGFMGYSAENIPGCS SSGSCSQGSGILHYAHGDSQQTHLL KQGRSSMGTGLSGGKRPSQEEDTQS IGPKVQRQSTN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CRY1 cryptochrome 1 (photolyase-like) [ Homo sapiens ]
• Official Symbol: CRY1
• Synonyms: CRY1; cryptochrome 1 (photolyase-like); PHLL1; cryptochrome-1; photolyase-like cryptochrome 1
• Gene ID: 1407
• mRNA Refseq: NM_004075
• Protein Refseq: NP_004066
• MIM: 601933
• UniProt ID: Q16526