CRYZ
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Official Full Name
crystallin, zeta (quinone reductase)
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Overview
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. -
Synonyms
CRYZ; crystallin, zeta (quinone reductase); quinone oxidoreductase; NADPH:quinone reductase; Zeta crystallin; Crystallin zeta (quinone reductase); Crystallin zeta; DKFZp779E0834; FLJ41475; MS766; QOR_HUMAN; Zeta-crystallin; OTTHUMP00000011194; OTTHUMP00000011210; OTTHUMP00000011211; OTTHUMP00000011213;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CRYZ involved in several pathways and played different roles in them. We selected most pathways CRYZ participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
CRYZ has several biochemical functions, for example, NOT NADH binding, NADPH binding, NADPH:quinone reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYZ itself. We selected most functions CRYZ had, and list some proteins which have the same functions with CRYZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT NADH binding | |
| NADPH binding | GRHPR;CBR3;CBR4;QDPR;MTRR;KCNAB1;FASN;DHFR;TP53I3 |
| NADPH:quinone reductase activity | TP53I3;CRYZL1;ADH4;CRYZ |
| mRNA 3-UTR binding | CPEB1;HNRNPC;FXR1;RBMS3;PARN;CPEB1B;PUM1;CIRBP;RNF20 |
| zinc ion binding | TRIM55A;LIMK1;MICAL1;ADH1C;ZNF185;NR6A1;PPARD;XAF1;CA4A |
CRYZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYZ here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYZ.
MCC; IKBKE; ssrna_au; CSNK2A2; CBX5; Smek1; Ppp6r1; ASPM; ZNF526; Mad2l1bp; Cul3
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