The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of
the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in
epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for
cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18,
occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct
DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP; DSC3; desmocollin 3; desmocollin-3; desmocollin-4; cadherin family member 3; 5430426I24Rik
Aizawa, S; Ochiai, T; et al. Heterogeneous and abnormal localization of desmosomal proteins in oral intraepithelial neoplasms. JOURNAL OF ORAL SCIENCE 56:209-214(2014).
Sezin, T; Avitan-Hersh, E; et al. Human Amnion Membrane as a Substrate for the Detection of Autoantibodies in Pemphigus Vulgaris and Bullous Pemphigoid. ISRAEL MEDICAL ASSOCIATION JOURNAL 16:217-223(2014).