|Official Full Name||epithelial cell transforming sequence 2 oncogene|
|Background||The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.|
|Synonyms||ECT2; epithelial cell transforming sequence 2 oncogene; protein ECT2; ARHGEF31; ECT 2; ECT2 protein; Epithelial Cell Transforming Sequence 2; Epithelial cell transforming sequence 2 oncogene protein; FLJ10461; MGC138291; OTTHUMP00000210539; OTTHUMP00000210684; OTTHUMP00000210685; OTTHUMP00000210686; epithelial cell-transforming sequence 2 oncogene|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ECT2 involved in several pathways and played different roles in them. We selected most pathways ECT2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cell death signalling via NRAGE, NRIF and NADE||KALRN; ECT2; ITGB3BP; FGD2; BCL2L11; ARHGEF17; ITSN1; NET1; ARHGEF18; ARHGEF1A|
|G alpha (12/13) signalling events||ARHGEF9; TRIO; ARHGEF1B; ECT2; NET1; ITSN1; RHOC; ADRA1D; OBSCN; FGD2|
|GPCR downstream signaling||TRH; PENK; GPR4; TAS2R13; PROKR2; ECT2; ADCYAP1B; AKAP13; PTHLHA; HRH3|
|Gastric cancer network 1||ECT2; RNF216; SMOC2; MYBL2; LIN9; TPX2; GATS; ESM1; S100P; C21orf33|
|NRAGE signals death through JNK||TIAM2; MCF2L; ECT2; ARHGEF17; ARHGEF18; PLEKHG2; FGD2; FGD4A; ABR; ARHGAP4|
|PLK1 signaling events||ECT2; SPC24; BORA; ERCC6L; TPT1; PLK1S1; NDC80; TCTN2; TPX2|
|Regulation of RhoA activity||PLEKHG6; ARHGEF25; NET1; DLC1; ARHGAP4; ARAP1; MYO9B; DEF6; FARP1; OBSCN|
|Rho GTPase cycle||ARHGAP29B; DCLRE1B; ARHGEF18; ARHGEF1A; TAGAP; PLEKHG2; ARHGAP36; ARHGAP12B; ARHGAP6; MYO9B|
ECT2 has several biochemical functions, for example, GTPase activator activity, Rho GTPase binding, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ECT2 itself. We selected most functions ECT2 had, and list some proteins which have the same functions with ECT2. You can find most of the proteins on our site.
|GTPase activator activity||ASAP2B; ARHGAP42; RGS12; AGAP2; STARD8; ARHGEF1; TBC1D9; GARNL3; ALDH1A2; RGS3|
|Rho GTPase binding||ROCK2B; INF2; DIAP1; PARD6A; ECT2; DOCK10; LRRK2; ARHGEF2; FMNL2; FLNA|
|Rho guanyl-nucleotide exchange factor activity||TRIO; ARHGEF25; C9orf100; ARHGEF7A; MCF2L; FARP2; FARP1; ARHGEF28; KALRNB; BCR|
|protein binding||LOXL3; TRPC3; MAPK9; CTPS2; CLIC2; SMNDC1; FAM125A; PDLIM5; STX11; ZIC3|
|protein homodimerization activity||C9orf142; SLC39A13; FOXP3; DMBX1; PON3; NADK2; NADKD1; PYGL; TESC; CRYBA1|
|signal transducer activity||HMOX1; PLCG2; AGTR1B; FAS; OLFCG5; CC2D1A; OLFR147; GNAL; CSPG4; TAAR13C|
ECT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECT2.
RACGAP1; MYC; NCK1; PIK3R1; GRB2; Ect2; LAMTOR5; GPSM2; SAMD1; RBM45; SKA3