elk4
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  • Official Full Name
  • ELK4, ETS-domain protein (SRF accessory protein 1)
  • Background
  • This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.
  • Synonyms
  • ELK4; ELK4, ETS-domain protein (SRF accessory protein 1); ETS domain-containing protein Elk-4; SAP1; ELK4_HUMAN; ETS domain containing protein Elk4; ETS domain protein; SAP-1; Serum response factor accessory protein 1; SRF accessory protein 1; TCF1; OTTHUMP00000035338; OTTHUMP00000035339
Cat.#:ELK4-3246HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ELK4 Protein, GST-tagged
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Cat.#:ELK4-28290THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ELK4
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Cat.#:ELK4-780HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ELK4 Protein, His-tagged
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Cat.#:ELK4-5136MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ELK4 Protein
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Cat.#:ELK4-1444RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ELK4 Protein, His-tagged
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Cat.#:ELK4-8571ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ELK4
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Cat.#:ELK4-6627HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ELK4 293 Cell Lysate
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Cat.#:ELK4-6628HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ELK4 293 Cell Lysate
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Involved Pathway

ELK4 involved in several pathways and played different roles in them. We selected most pathways ELK4 participated on our site, such as MAPK signaling pathway, HTLV-I infection, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELK4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RASA1; NTRK1; FGFR1A; RPS6KA2; PDGFRB; CACNA1H; GADD45BB; RAC3A; MRAS; FGFR2
HTLV-I infection
DVL3; IKBKB; HLA-B; EGR2; POLB; ATF3; KAT2A; AKT1; ATF1; CD3D
Transcriptional misregulation in cancer
DOT1L; PAX5; LDB1; PAX3; BMI1; ETV5; REL; SIX4; HIST2H3C2; MYCN

Protein Function

ELK4 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELK4 itself. We selected most functions ELK4 had, and list some proteins which have the same functions with ELK4. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NKX6.2; TLX3B; TBX6; TOP1L; SP2; SCML2; ELMSAN1A; FOXP1A; LEF1; TRIM28
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXI2; FOXQ1B; ZNF202; ATF5A; FOXG1B; EPAS1; MKX; SOX8; ATF4; SPDEF
Function chromatin binding
Related Protein PRKCB; CCNT1; ERG; MSL1A; EBF2; GATA1A; CBX1; NONO; GABPA; PRKAA1
Function core promoter binding
Related Protein GATA1; IFI203; CALCOCO1; IRF9; AGO1; GADD45A; KDM3A; HNRNPU; SFPQ; NKX3
Function protein binding
Related Protein AKR7A3; SRPK3; CSNK2A2; MRPL28; BID; TOP2A; PLSCR1; COG8; LRRC33; BCL2L10
Function sequence-specific DNA binding
Related Protein TBX3; SIX4B; FOXO1; DLX4A; RERE; EVE1; MKXA; GLI1; FOXN4; CDX1B
Function transcription cofactor activity
Related Protein CREB1; LPXN; ZNF212; MED12; HES6; TFDP2; MED24; SUPT20H; TRIP13; MED30
Function transcription factor activity, sequence-specific DNA binding
Related Protein WT1B; ZFP367; FOXC1; RORAB; NR1D1; HMGA1; ZIK1; SNAPC4; ZNF501; MTA2

ELK4 Related Articles

Ren, GP; Zhang, YL; et al. Transcription-Mediated Chimeric RNAs in Prostate Cancer: Time to Revisit Old Hypothesis?. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY 18:615-624(2014).
Weinl, C; Wasylyk, C; et al. Elk3 Deficiency Causes Transient Impairment in Post-Natal Retinal Vascular Development and Formation of Tortuous Arteries in Adult Murine Retinae. PLOS ONE 9:-(2014).