elane
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  • Official Full Name
  • elastase, neutrophil expressed
  • Background
  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the proteins release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
  • Synonyms
  • ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; neutrophil elastase; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow serine protease; granulocyte-derived elastase;
Cat.#:ELANE-1197HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ELANE Protein, GST-tagged
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Cat.#:ELANE-3222HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ELANE Protein, GST-tagged
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Cat.#:ELANE-1653HTag:
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameHuman Elastase
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Cat.#:ELANE-172HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ELANE Protein, His/GST-tagged
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Cat.#:ELANE-201HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ELANE
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Cat.#:Elane-694MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Elane Protein, His-tagged
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Cat.#:Elane-906MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Elane, His tagged
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Cat.#:ELANE-001HTag:
Source (Host):Human NeutrophilsSpecies:Human
Product nameNative Human ELANE Protein
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Cat.#:ELANE-27537THTag:
Source (Host):Species:Human
Product nameNative Human ELANE
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Cat.#:ELANE-3221HTag:
Source (Host):Human bloodSpecies:Human
Product nameNative Human ELANE Protein
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Cat.#:ELANE-8104HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human Neutrophil Elastase
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Cat.#:ELANE-8236HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human Neutrophil Elastase (ELA-2)
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Cat.#:ELANE-2381MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ELANE cell lysate
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Cat.#:Kit-0322Tag:
Source (Host):Species:
Product nameNeutrophil Elastase Activity Assay Kit
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Cat.#:Kit-0323Tag:
Source (Host):Species:
Product nameNeutrophil elastase colorimetric drug discovery Kit
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Cat.#:Kit-0321Tag:
Source (Host):Species:
Product nameELANE Inhibitor Screening Kit
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Involved Pathway

Elane involved in several pathways and played different roles in them. We selected most pathways Elane participated on our site, such as Activation of Matrix Metalloproteinases, C-MYB transcription factor network, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Elane were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
FURINA; CTSLL; FURINB; ELANE; MGC174155; CTRB1; MGC174857; MMP10; MMP17; TIMP2
C-MYB transcription factor network
CLTA; MYC; PRTN3; TOM1; GATA1; ELANE; CREBBP; ADORA2B; CBX4; PTCRA
Collagen degradation
MMP11; LOC100686744; MGC174857; CTSLL; TLDC2; CTS7; MMP8; MGC174155; CTSL1; COL25A1
Degradation of the extracellular matrix
COL25A1; CTSLL; MMP8; MGC174152; ADAMTS5; TLL1; ACAN; ADAM8; ADAMTS8; COL19A1
Extracellular matrix organization
TLL1; ADAMTS4; FURINB; MGC174155; COL16A1; LOX; TIMP2A; PRP; COL28A1A; CTSD
Systemic lupus erythematosus
ACTN3; HIST1H2BO; C8B; FCGR2A; HIST1H2BG; HLA-DPA1; ACTN1; HIST1H2BL; TROVE2; C1S
Transcriptional misregulation in cancer
TMPRSS2; PTCRA; WNT16; Bcl2a1b; WT1; SIX4; RELA; ELANE; IL2RB; ZBTB17
amb2 Integrin signaling
MST1; ELANE; NIPAL1; CYR61; MST1R; LPA; HP

Protein Function

Elane has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, cytokine binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Elane itself. We selected most functions Elane had, and list some proteins which have the same functions with Elane. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription corepressor activity
Related Protein SIN3AA; SIN3B; BEND6; ELANE; SOX3; TXLNB; N4BP2L2; NFIB; TBX18; CTBP1
Function cytokine binding
Related Protein CHRD; CNTFR; CSF1RA; ELANE; Fzd4; NRP1; KITA; CXCR4; LIFR; IL31RA
Function endopeptidase activity
Related Protein PSMB10; CTSH; ELANE; PSMA6B; PSMB11; KLK1B8; KLK1B11; PSMA3; RHBDD1; PSMA1
Function heparin binding
Related Protein SERPINA10; LAMC2; ECM2; PTPRF; ADAMTSL5; RSPO4; COMP; THBS2; LIPI; GREM2
Function peptidase activity
Related Protein DUB1; SOLH; PRSS42; THSD4; TMPRSS11G; CLCA3; C6AST3; BMP1B; MMP23BB; CAPN2A
Function protease binding
Related Protein TRIP4; TIMP2A; MBP; CD28; STIM1; PYCARD; TIMP2B; POLG; KIT; XBP1
Function protein binding
Related Protein CTNNA3; KRT33B; HOXA9; BCL2L14; SOSTDC1B; MRPS16; ZRANB1; ZFP2; TRIM21; MTMR2
Function serine-type endopeptidase activity
Related Protein PRSS46; PRSS33; FAM108A1; FAP; ST14A; PRSS58; HTRA1B; C1RL; PRTN3; Prss32

Interacting Protein

Elane has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Elane here. Most of them are supplied by our site. Hope this information will be useful for your research of Elane.
SERPINA1; SLPI; iovo_melga; Col17a1; GZMB; P/V/C