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GATA1

  • Official Full Name

    GATA binding protein 1 (globin transcription factor 1)

  • Overview

    This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
  • Synonyms

    GATA1; GATA binding protein 1 (globin transcription factor 1); GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1; erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; nuclear factor, erythroid 1; globin transcription factor 1; erythroid transcription factor 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GATA1-140H Recombinant Human GATA1 Protein, His-tagged E.coli His
Human GATA1-2052H Recombinant Human GATA1, GST-tagged Wheat Germ GST
Human GATA1-28476TH Recombinant Human GATA1, His-tagged E.coli His
Human GATA1-689HCL Recombinant Human GATA1 cell lysate N/A
Human GATA1-1962HFL Recombinant Full Length Human GATA1 Protein, N-His-tagged E.coli His
Human GATA1-6938HF Recombinant Full Length Human GATA1 Protein, GST-tagged In Vitro Cell Free System GST 413 amino acids
Mouse Gata1-474M Recombinant Mouse Gata1 Protein, His-tagged E.coli His Asp20~Thr265
Mouse GATA1-6222M Recombinant Mouse GATA1 Protein Mammalian Cell His
Mouse GATA1-3481M Recombinant Mouse GATA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GATA1-3481M-B Recombinant Mouse GATA1 Protein Pre-coupled Magnetic Beads HEK293
Rat Gata1-475R Recombinant Rat Gata1 Protein, His-tagged E.coli His Asp42~Asn292
Rat GATA1-2481R Recombinant Rat GATA1 Protein Mammalian Cell His
Rat GATA1-2137R-B Recombinant Rat GATA1 Protein Pre-coupled Magnetic Beads HEK293
Rat GATA1-2137R Recombinant Rat GATA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GATA1-7013C Recombinant Chicken GATA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GATA1 Related Articles

GATA1 involved in several pathways and played different roles in them. We selected most pathways GATA1 participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
C-MYB transcription factor networkMYOD1;LECT2;CLTA;SLC25A3;ADORA2B;CBX4;SKI;SMARCA2;CEBPA
Factors involved in megakaryocyte development and platelet productionHBD;KIF9;KIF5B;NFE2;HBG1;KIF3A;BA2;KIF11;ZFPM1
HemostasisD-AKAP2;F11R.2;CD9B;BSG;SERPINE2;BA2;HBBE2;DGKB;FCER1GL
IL-3 Signaling PathwayBIRC5A;GATA2A;SPI1B;GATA2;KCNIP3B;BMX;PILRB;GATA1;GSK3AB
Notch-mediated HES/HEY networkTLE1;MYOD1;YY1;ASCL1;BGLAP;RCAN1;GATA1;MYB;CTBP1
Signaling events mediated by HDAC Class INR2C1;MXD1;SIRT2;GATA2;GATA1;SIRT5;PRMT5;SIRT7;WDR77
Signaling events mediated by HDAC Class IIBCOR;ANKRA2;GATA1

GATA1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA1 itself. We selected most functions GATA1 had, and list some proteins which have the same functions with GATA1. You can find most of the proteins on our site.

Function Related Protein
C2H2 zinc finger domain bindingHMGA2;EBF1;GATA1;EHMT2;U2AF2;TAF9;WT1;THAP7;EHMT1
DNA bindingFOXN2B;ZMAT4;INO80;FOXP3A;PKNOX1.1;ZNF16;ZNF703;CBFB;POLR2E
DNA binding, bendingHMGB2;LEF1;HMGB3;TERF1;FOXD4;GATA1;TOP2B;CRIP1;HHEX
RNA polymerase II core promoter proximal region sequence-specific DNA bindingZNF562;STAT3;PLAG1;CEBPG;ELK3;MESP1;ZNF217;MEF2A;MAFB
RNA polymerase II core promoter sequence-specific DNA bindingGATA6;HNF4A;ZFPM1;HOXB3;SMAD1;ZNF335;NLRC5;SP3;MITF
RNA polymerase II regulatory region sequence-specific DNA bindingPHOX2A;ZBTB11;H2AFY;ZNF79;AIRE;DLX2;MNT;BCL6;PHOX2B
RNA polymerase II transcription factor bindingAr;XBP1;TBX6;SPI1;HCLS1;MTDH;GATA2B;NFATC1;KLF4
chromatin DNA bindingNEUROG3;GATA1;GRHL1;SLAMF7;EP300;PER1;INSM1A;INSM1B;BCL6
core promoter bindingCLOCK;KDM3A;NONO;TFAP2C;ELK1;AGO1;NKX3;XBP1;DHX36
enhancer sequence-specific DNA bindingSOX9;XBP1;SOX11;GATA1;LMO4;ATF2;FOXN4;TFAP2B;MYT1
p53 bindingTP63;CDKN2A;TAF3;MDM2;RNF20;GATA1;HTT;ZFP385C;TRIM24
protein bindingSPATC1;LBX1;VEGFA;RPS6KC1;DNMT3B;TAB1;NXF1;GNS;ERRFI1
sequence-specific DNA bindingNFE2;GATA2B;GATAD1;FOXN2;HOXB13;POU3F3;GSX2;FOXC1;RXRGB
transcription factor activity, sequence-specific DNA bindingVDRA;ZNF239;ZKSCAN17;RUNX2A;CHES1;ZNF573;HEY1;USF2;POU3F4
transcription regulatory region sequence-specific DNA bindingSIN3A;MEF2CA;SUV39H2;BAHD1;SOX4;TBX18;MKL1;EGR1;MEF2AA
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingHMGA2;HNF4A;NRF1;FOXD1;NFKB2;ONECUT2;NR1H2;ARNT2;PITX1
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingFEZF2;FOXF2;SLAMF7;GATA4;NEUROD2;SOX17;BARHL1A;GATA6;SRF
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingNFIL3-5;GCFC2;SP3;RCOR1;MLXIPL;ZFP746;ZNF148;CUX2;REST
zinc ion bindingMKRN4;PEX2;LMO7B;TRIM35;RAD18;PIAS1;RARG;AEBP1;PDLIM3A

GATA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA1.

FRS3; PRKAB2; HOXA1; KRTAP10-5; CCDC24; FBF1; RADIL

Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).
  • Q&As
  • Reviews

Q&As (5)

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Is GATA1 involved in the regulation of immune responses? 03/21/2021

GATA1 primarily functions in hematopoiesis and is not directly involved in the regulation of immune responses. Its role is more specific to blood cell development.

Are there clinical conditions associated with GATA1 mutations? 10/23/2017

Yes, mutations in the GATA1 gene are linked to various hematological disorders, including Diamond-Blackfan anemia and transient myeloproliferative disorder in Down syndrome.

How does understanding GATA1 help in the prognosis of hematological disorders? 04/05/2017

Knowledge of GATA1 mutations can contribute to a more accurate prognosis, guiding healthcare professionals in developing appropriate treatment plans and monitoring strategies.

Can GATA1 mutations lead to leukemia? 01/14/2017

Yes, mutations in the GATA1 gene have been implicated in the development of acute megakaryoblastic leukemia, particularly in children with Down syndrome.

How does GATA1 contribute to normal blood cell function? 01/05/2017

GATA1 controls the expression of genes necessary for normal blood cell development, ensuring proper function and regulation of erythrocytes and platelets.

Customer Reviews (3)

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Reviews
05/01/2021

    Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

    12/25/2018

      The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

      07/24/2017

        In addition to its scientific merits, the manufacturer of GATA1 protein stands out for its outstanding technical support.

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