gata1
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  • Official Full Name
  • GATA binding protein 1 (globin transcription factor 1)
  • Background
  • This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GATA1; GATA binding protein 1 (globin transcription factor 1); GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1; erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; nuclear factor, erythroid 1; globin transcription factor 1; erythroid transcription factor 1;
Cat.#:GATA1-140HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GATA1 Protein, His-tagged
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Cat.#:GATA1-2052HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GATA1, GST-tagged
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Cat.#:GATA1-28476THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GATA1, His-tagged
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Cat.#:Gata1-474MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gata1 Protein, His-tagged
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Cat.#:GATA1-6222MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GATA1 Protein
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Cat.#:GATA1-2481RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GATA1 Protein
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Cat.#:Gata1-475RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gata1 Protein, His-tagged
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Cat.#:GATA1-7013CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GATA1
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Cat.#:GATA1-689HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GATA1 cell lysate
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Involved Pathway

GATA1 involved in several pathways and played different roles in them. We selected most pathways GATA1 participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
C-MYB transcription factor network
PIAS3; GATA1; PTCRA; SKI; COL1A2; YEATS4; MYOD1; CDKN1B; PRTN3; MYF6
Factors involved in megakaryocyte development and platelet production
HBG1; MAFGB; ZFPM1; GATA2; BA1; KIF3B; NFE2; PHF21A; MFN1; HMG20B
Hemostasis
HBG1; HBE1; PDPN; LOC100514666; DGKB; MYB; GRB14; AKAP10; G6b; SLC7A11
IL-3 Signaling Pathway
GATA1A; BMX; BIRC5A; CISH; SPI1B; GATA1; KCNIP3; GNB2L1; KCNIP3B; GATA2
Notch-mediated HES/HEY network
RCAN1; HEY1; MYOD1; MYB; GATA1; CTBP1; TLE1; HES6; GATA6; YY1
Signaling events mediated by HDAC Class I
FKBP3; WDR77; SIRT5; TFCP2; SIRT4; MXD1; PRMT5; SIRT2; GATA2; SIRT7
Signaling events mediated by HDAC Class II
BCOR; ANKRA2; GATA1

Protein Function

GATA1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA1 itself. We selected most functions GATA1 had, and list some proteins which have the same functions with GATA1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein TAF9; LEF1; GATA2; EHMT2; HMGA2; U2AF2; ZXDC; GATA1; WT1; EHMT1
Function DNA binding
Related Protein MXD4; ZNF671; SP8B; KDM5C; RXRGB; NFE2L2; NHEJ1; NR2F5; HUWE1; NR6A1A
Function DNA binding, bending
Related Protein HMGB3; FOXC1; HMGA2; TERF1; HHEX; CRIP1; FOXL1; LEF1; SRY; HMGB1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein CRX; KDM6A; NFIC; SMAD3; SOX1; MXD1; CDX4; GRHL1; TCF4; SREBF1
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein YAP1; HNF4A; RREB1; EP300; IRF7; TAL1; SMAD5; GATA3; SOX8; TFAP2A
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein ZMYND11; ARID3A; PURB; ARID5B; PHF21A; GFI1AA; ASCL3; SP1; BARHL1B; EGR1
Function RNA polymerase II transcription factor binding
Related Protein CREBBP; TBX3; ZFPM2; XBP1; PITX2; GATA2A; GATA6; Ar; DHX9; SPI1
Function chromatin DNA binding
Related Protein ZIC2; NEUROG3; NOTCH1; HIST1H1D; ACTN4; HDAC3; HIST1H1E; VAX1; AASS; RUVBL2
Function core promoter binding
Related Protein NKX2-1; HDAC5; SAFB; RELB; XBP1; RB1; GTF2B; KLF4; HDAC1; MYOD1
Function enhancer sequence-specific DNA binding
Related Protein XBP1; TFAP2B; KLF7B; ATF2; ISL1; LDB1; KLF6A; TWIST1B; LMO4; GATA5
Function p53 binding
Related Protein BRD4; NTRK3; AXIN1; TAF1; USP10; RNF20; MSX1; SMARCA4; CDKN2A; TRIM29
Function protein binding
Related Protein C1orf38; FAM86C; NME5; PRC1; HSD17B8; SLC6A4; KRTAP3-1; COX5A; IL5; FAM101A
Function sequence-specific DNA binding
Related Protein NKX2.5; RORAA; ATF4B2; ENG2B; FOXG1D; HMX3; WT1; NR2F1; PBX1B; DMBX1
Function transcription factor activity, sequence-specific DNA binding
Related Protein BCL6; FOXN4; CARF; SOX2; ZNF726; GRHL2B; NR1D4B; HOXB6B; SMAD3A; PBX1B
Function transcription regulatory region sequence-specific DNA binding
Related Protein HDAC1; NR5A1A; BACH1B; TFAP2A; ARNTL; NONO; PSPC1; POU5F1; NR5A2; PER2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MITF; GMEB1; CEBPZ; OTX1; HIF1A; ZIC3; EBF3A; CRX; TP53; MEOX1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein TRP53; RAD21; MAFBB; PKNOX1; REST; HOXD8; CSRNP2; CEBPA; SRF; EAF2
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MYPOP; BACH1; EN1; HELT; CC2D1A; POU4F2; NKX6-1; GCFC2; YY1; IFI203
Function zinc ion binding
Related Protein SUV39H1B; MT1A; LIMCH1B; S100A7; DPF3; SIAH1; MGRN1B; ZDHHC16; HHIP; ZDHHC21

Interacting Protein

GATA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA1.
FRS3; PRKAB2; HOXA1; KRTAP10-5; CCDC24; FBF1; RADIL

GATA1 Related Articles

Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).