gata1
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  • Official Full Name
  • GATA binding protein 1 (globin transcription factor 1)
  • Background
  • This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GATA1; GATA binding protein 1 (globin transcription factor 1); GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1; erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; nuclear factor, erythroid 1; globin transcription factor 1; erythroid transcription factor 1;
Cat.#:GATA1-140HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GATA1 Protein, His-tagged
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Cat.#:GATA1-2052HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GATA1, GST-tagged
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Cat.#:GATA1-28476THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GATA1, His-tagged
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Cat.#:Gata1-474MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gata1 Protein, His-tagged
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Cat.#:GATA1-6222MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GATA1 Protein
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Cat.#:GATA1-2481RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GATA1 Protein
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Cat.#:Gata1-475RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gata1 Protein, His-tagged
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Cat.#:GATA1-7013CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GATA1
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Cat.#:GATA1-689HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GATA1 cell lysate
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Involved Pathway

GATA1 involved in several pathways and played different roles in them. We selected most pathways GATA1 participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
C-MYB transcription factor network
CLTA; LECT2; ELANE; CEBPB; SLC25A3; MYOD1; SMARCA2; MYB; COL1A2; SKI
Factors involved in megakaryocyte development and platelet production
KDM1A; ZFPM1; CBX5; GATA1A; MYB; DOCK2; H3F3B.1; ZFPM2A; GATA6; MAFF
Hemostasis
DOCK7; TREM1; HBE1; IRF2; ANGPT2A; SH2B3; WDR1; KIF5B; F3A; CBX5
IL-3 Signaling Pathway
GATA2A; SPI1B; GATA1; BMX; GNB2L1; KCNIP3B; GATA2; CISH; GSK3AB; KCNIP3
Notch-mediated HES/HEY network
GATA1; RCAN1; HES6; HEY1; ASCL1; BGLAP; TLE1; GATA6; CTBP1; MYOD1
Signaling events mediated by HDAC Class I
MXD1; NR2C1; SIRT2; FKBP3; SIRT4; TFCP2; SIRT7; GATA2; WDR77; GATA1
Signaling events mediated by HDAC Class II
ANKRA2; GATA1; BCOR

Protein Function

GATA1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA1 itself. We selected most functions GATA1 had, and list some proteins which have the same functions with GATA1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein GATA2; THAP7; HMGA2; WT1; TAF9; ZXDC; EHMT1; EHMT2; EBF1; U2AF2
Function DNA binding
Related Protein HOXB2A; ZNF333; ARID3C; OTPA; LBX2; ERCC6L2; XBP1; POLM; HIST1H3C; ZFP39
Function DNA binding, bending
Related Protein FOXC1; SRY; HMGB1; LEF1; HMGA2; HMGB3; FOXD4; TFAM; CRIP1; TOP2A
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein MITFB; NFATC3; ALS2CR8; RFX4; ZGPAT; MYF5; FUBP3; TCF7L2; HOXD13; CTCF
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein NR4A2; RUVBL2; EP300; SOX11; TP53; STAT5A; MTF1; GATA3; NLRC5; ZNF277
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein H2AFY2; CEBPB; ZNF792; MYOG; TAL1; CUX1; JARID2; RXRA; PHF21A; FOXF2
Function RNA polymerase II transcription factor binding
Related Protein GATA2B; GATA1A; GATA1; KDM1A; PITX2; XBP1; CREBBP; HCLS1; CHST13; ZFPM2
Function chromatin DNA binding
Related Protein H1F0; RELA; THRA; MYOG; H2AFZ; SMAD3; ATOH1; GRHL3; AASS; VAX2
Function core promoter binding
Related Protein E2F3; HDAC1; E2F8; MED1; PSPC1; NKX3-1; NKX3; NEUROG3; EZH2; HDAC5
Function enhancer sequence-specific DNA binding
Related Protein LDB1; XBP1; LMO4; GATA4; SOX11; YY1; GATA5; ISL1; TBX19; GATA3
Function p53 binding
Related Protein RFFL; TAF9; TAF3; GSK3B; ZNF385A; TP63; TRIM24; TP73; TP53BP1; BRD4
Function protein binding
Related Protein SORBS3; PVRL2; NXF2; MBL2; TMEM123; PDE4D; SGTA; NUDT10; SEPT9; DLG1
Function sequence-specific DNA binding
Related Protein FOXE3; NFE2; SPI1B; HOXC10A; HOXC12B; RXRAA; MIXL1; HMX4; SIX1A; ESRRGA
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF550; ARNTL1A; DBPA; TSC22D1; VDRA; MZF1; HEYL; TP63; ZNF577; TRIM25
Function transcription regulatory region sequence-specific DNA binding
Related Protein CREB3L3; ZNF658; KCNA3; MEF2CA; SOX2; SOX12; NR5A5; NFE2L1A; NFE2; NFE2L2A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MEF2B; MYOCD; TFAP2B; IRF1; NR4A2; NR1H2; PATZ1; SMAD1; NR1H4; ZFP292
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein AIRE; CSRNP1; OVOL2; GATA6; GATA2; ESRRG; PAX9; GATA1; MYF5; CREBBP
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein RELA; POU4F2; CC2D1A; NKX3-2; NFIL3-2; ZNF217; ZKSCAN3; TBX3; DACH1; ASCL2
Function zinc ion binding
Related Protein SHANK3; ADAM5P; LIMCH1B; ZDHHC2; MMP11; KAT7A; HE1B; MEP1B; CRIP3; ADAMTS15A

Interacting Protein

GATA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA1.
FRS3; PRKAB2; HOXA1; KRTAP10-5; CCDC24; FBF1; RADIL

GATA1 Related Articles

Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).