gne
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  • Official Full Name
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Background
  • The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
  • Synonyms
  • GNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; IBM2, UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Uae1; IBM2; 2310066H07Rik; Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; DMRV; ManAc kinase; N acylmannosamine kinase; NM; RP23-209M8.6; UDP GlcNAc 2 epimerase; UDP GlcNAc 2 epimerase/ManAc kinase; Uridine diphosphate N acetylglucosamine 2 epimerase; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; GLCNE
Cat.#:GNE-5061HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNE Protein, GST-tagged
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Cat.#:GNE-13359HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNE, His-tagged
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Cat.#:GNE-94HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GNE, His-tagged
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Cat.#:GNE-2605RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNE Protein
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Cat.#:GNE-3081CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNE
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Cat.#:GNE-11130ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GNE
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Cat.#:GNE-5858HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GNE 293 Cell Lysate
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Involved Pathway

GNE involved in several pathways and played different roles in them. We selected most pathways GNE participated on our site, such as Amino sugar and nucleotide sugar metabolism, Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amino sugar and nucleotide sugar metabolism
CHIA.3; NANP; AMDHD2; CYB5R1; GALE; PGM3; CYB5R2; UGDH; CMASA; HEXA
Asparagine N-linked glycosylation
MCFD2; TRAPPC6A; ST8SIA2; USO1; CTAGE5; YKT6; MAN1B1; MPDU1A; NAPG; TFG
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
ST6GAL2B; ST8SIA3; ST6GALNAC1.2; MPDU1B; MPDU1A; SLC35A1; ST6GALNAC2; NEU3; ST8SIA2; NEU4
Metabolic pathways
ASAH1B; NDUFS8; ASMT; MAT2AL; PLA2G12A; OTC; NDUFA12; GAA; ACSL1A; SUCLG1
Metabolism of proteins
TIMM22; TIMM9; NAT8; RING1; CTAGE5; FBXW4; SAE1; WDR85; TRAPPC1; CNIH2
Post-translational protein modification
SPON1A; TMED10; MUC21; ADAMTS3; ST6GALNAC1.2; PROZ; ARSE; TRAPPC5; DPH1; SMC5
Sialic acid metabolism
ST6GAL2B; ST6GALNAC2; ST6GALNAC1.2; GNE; ST8SIA3; NANP; SLC35A1
Synthesis of substrates in N-glycan biosythesis
ST6GALNAC2; GNE; ST8SIA3; SLC35A1; ST6GAL2B; ST6GALNAC1.2

Protein Function

GNE has several biochemical functions, for example, ATP binding, N-acylmannosamine kinase activity, UDP-N-acetylglucosamine 2-epimerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNE itself. We selected most functions GNE had, and list some proteins which have the same functions with GNE. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TTBK2; ACTB1; GRK7; GLULA; DCAKD; SIK3; TOR1L1; PET112L; STK3; AAK1
Function N-acylmannosamine kinase activity
Related Protein GNE; NAGK
Function UDP-N-acetylglucosamine 2-epimerase activity
Related Protein GNE
Function hydrolase activity, hydrolyzing O-glycosyl compounds
Related Protein CHIA.3; CHIA.2; LCTL; Chil3; GNE; KLB; ABHD10; LCTLA; KIAA1161; CHIA.1
Function metal ion binding
Related Protein ASPA; ARL1; SALL2; PON3; AIFM4; ZFP28; CTH1; B4GALT4; CLCNKA; FREM2
Function protein binding
Related Protein ITGA2B; RCN3; RHOXF2; FNBP1; NKRF; CACYBP; PYCARD; RABL2A; HERC5; NR2C2AP

Interacting Protein

GNE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNE here. Most of them are supplied by our site. Hope this information will be useful for your research of GNE.
SPRY2; KRTAP5-9; KRTAP10-5; KRTAP10-7; KRTAP10-8; KRTAP10-9

GNE Related Articles

Weldon, RA; Fensin, ML; et al. Total neutron emission generation and characterization for a Next Generation Safeguards Initiative spent fuel library. PROGRESS IN NUCLEAR ENERGY 80:45-73(2015).
Broccolini, A; Mirabella, M; et al. Hereditary inclusion-body myopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:644-650(2015).