| Description : |
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
79.3 kDa |
| AA Sequence : |
MEKNGNNRKLRVCVATCNRADYSKL APIMFGIKTEPEFFELDVVVLGSHL IDDYGNTYRMIEQDDFDINTRLHTI VRGEDEAAMVESVGLALVKLPDVLN RLKPDIMIVHGDRFDALALATSAAL MNIRILHIEGGEVSGTIDDSIRHAI TKLAHYHVCCTRSAEQHLISMCEDH DRILLAGCPSYDKLLSAKNKDYMSI IRMWLGDDVKSKDYIVALQHPVTTD IKHSIKMFELTLDALISFNKRTLVL FPNIDAGSKEMVRVMRKKGIEHHPN FRAVKHVPFDQFIQLVAHAGCMIGN SSCGVREVGAFGTPVINLGTRQIGR ETGENVLHVRDADTQDKILQALHLQ FGKQYPCSKIYGDGNAVPRILKFLK SIDLQEPLQKKFCFPPVKENISQDI DHILETLSALAVDLGGTNLRVAIVS MKGEIVKKYTQFNPKTYEERINLIL QMCVEAAAEAVKLNCRILGVGISTG GRVNPREGIVLHSTKLIQEWNSVDL RTPLSDTLHLPVWVDNDGNCAALAE RKFGQGKGLENFVTLITGTGIGGGI IHQHELIHGSSFCAAELGHLVVSLD GPDCSCGSHGCIEAYASGMALQREA KKLHDEDLLLVEGMSVPKDEAVGAL HLIQAAKLGNAKAQSILRTAGTALG LGVVNILHTMNPSLVILSGVLASHY IHIVKDVIRQQALSSVQDVDVVVSD LVDPALLGAASMVLDYTTRRIYTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
