gng11
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), gamma 11
  • Background
  • This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas.
  • Synonyms
  • GNG11; guanine nucleotide binding protein (G protein), gamma 11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; G protein gamma 11 subunit; GNGT11; guanine nucleotide binding protein G(I)/G(S)/G(O) gamma 11 subunit; Guanine nucleotide binding protein G; Guanine nucleotide binding protein gamma 11; IG; Osubunit gamma 11 precursor; SG; OTTHUMP00000162594; G protein gamma-11 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit
Cat.#:GNG11-5064HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNG11 Protein, GST-tagged
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Cat.#:GNG11-13360HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNG11, GST-tagged
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Cat.#:GNG11-436HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human guanine nucleotide binding protein (G protein), gamma 11, His-tagged
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Cat.#:GNG11-5037HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNG11, His-tagged
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Cat.#:GNG11-7033MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GNG11 Protein
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Cat.#:GNG11-2606RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNG11 Protein
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Cat.#:GNG11-1901RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GNG11 Protein, His-tagged
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Cat.#:GNG11-5328CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNG11
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Cat.#:GNG11-5856HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GNG11 293 Cell Lysate
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Involved Pathway

GNG11 involved in several pathways and played different roles in them. We selected most pathways GNG11 participated on our site, such as Ras signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNG11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
AKT1; GNGT1; IGF1; FGF9; CSF1; GNB2; PAK2; PTPN11; AKT2; VEGFC
Chemokine signaling pathway
CX3CL1; ITK; GNB1; CXCR4; GRK5; CXCL8; NRAS; CCR5; CXCL14; GRK4
PIK-Akt signaling pathway
ITGA10; MTOR; FGF10; Il4ra; PCK2; PPP2R2C; PIK3R1; ITGB4; G6PC; ITGB5
Circadian entrainment
GNAI1; ITPR3; GNB1; GRIN2A; GNG3; CALM4; KCNJ9; PRKG2; RYR2; GNAQ
Retrograde endocannabinoid signaling
MAPK9; GABRB3; GNG12; GRIA4; ABHD6; GRIA3; GNB3; GNG8; DAGLB; MAPK10
Glutamatergic synapse
TRPC1; GNG12; SLC38A2; GRIN1; GNAO1; GRIK4; GNAQ; GRIA4; SLC1A3; PPP3R1
Cholinergic synapse
KCNJ6; KCNQ2; KCNJ14; GNAO1; CHRNB4; CAMK2B; AKR1C1; GNG8; GNGT1; GNAQ
Serotonergic synapse
PRKCG; SLC18A2; GNG8; TPH1; GNGT1; BRAF; CYP2C37; GABRB3; GNAQ; KCND2
GABAergic synapse
GABBR2; GABRQ; GNB2; GNAO1; GAD2; GNB1; PRKCB; GABARAP; GLS2; Adcy4
Dopaminergic synapse
GNAI1; KCNJ5; PPP2R5B; MAOA; CLOCK; PPP2R2B; PPP2R5E; DRD3; CALM2; AKT1
Morphine addiction
GABRB1; OPRM1; GABRR1; GNG3; GNG7; PDE3B; GABRE; GABRA3; Adcy4; GABBR2
Alcoholism
H2AFY; DRD1; HIST3H3; HDAC1; HIST1H2BP; CALM1; PRKACA; HIST1H2AF; GRIN3A; ATF6B
Pathways in cancer
NKX3; GNA11; WNT8B; HHIP; GSK3B; GLI2; EP300; TRAF4; HGF; PTGER3

Protein Function

GNG11 has several biochemical functions, for example, GTPase activity, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNG11 itself. We selected most functions GNG11 had, and list some proteins which have the same functions with GNG11. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activity
Related Protein GNL3; DNM1A; GNAI2A; GBP3; RALAA; GBP4; RAB14; ARHGAP5; ARF1; RAB3D
Function signal transducer activity
Related Protein OPN4XA; OLFR10; TAS2R130; GAB1; GNA11B; ADRA2DA; OLFR78; TAAR10D; PLCL1; GNAV1

Interacting Protein

GNG11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNG11 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNG11.
SMURF1; ZHX1; AMOTL2

GNG11 Related Articles

Fang, F; Pan, J; et al. Identification of Potential Transcriptomic Markers in Developing Ankylosing Spondylitis: A Meta-Analysis of Gene Expression Profiles. Biomed Research International :-(2015).
Xue, DB; Lu, M; et al. Screening for transcription factors and their regulatory small molecules involved in regulating the functions of CL1-5 cancer cells under the effects of macrophage- conditioned medium. ONCOLOGY REPORTS 31:1323-1333(2014).