• Official Full Name
  • HCLS1 associated protein X-1
  • Background
  • The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HAX1; HCLS1 associated protein X-1; HCLS1-associated protein X-1; HCLS1 (and PKD2) associated protein; HCLSBP1; HS1BP1; FLJ17042; FLJ18492; FLJ93803; HAX 1; Hax1a; HCLS1 and PKD2 associated protein; HCLS1 associated protein; HCLS1 associated protein X 1; HS 1 associated protein X 1; HS 1 binding protein; HS1 associating protein X 1; HS1 binding protein 1; HS1 binding protein; OTTHUMP00000034190; SCN3; HAX-1; HSP1BP-1; HS1-binding protein 1; HS1-associating protein X-1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HAX1 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HAX1, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HAX1, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HAX1, His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HAX1 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HAX1 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HAX1
Source (Host):Species:Human
Product nameRecombinant Human HAX1 293 Cell Lysate
Source (Host):Species:Human
Product nameRecombinant Human HAX1 293 Cell Lysate

Protein Function

HAX1 has several biochemical functions, for example, interleukin-1 binding, protein N-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAX1 itself. We selected most functions HAX1 had, and list some proteins which have the same functions with HAX1. You can find most of the proteins on our site.
Related Protein
Function interleukin-1 binding
Related Protein TRIM16; A2M; HAX1
Function protein N-terminus binding
Related Protein TSC1; FEZ1; KCNIP2; APTX; KCNQ2; PEX14; TP53; RPA2; PIAS3; ARF6
Function protein binding
Related Protein CLTA; CSF2RB; HRK; PPP1CC; GNA14; SH3YL1; ZFYVE21; EMG1; EID1; LRP12

Interacting Protein

HAX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAX1.
vpr; TPCN2; MAPK10; ESR1; TPCN1; GRB7; a8k1f4_human; XPO1; Abcb11

HAX1 Related Articles

Laffleur, B; Duchez, S; et al. Self-Restrained B Cells Arise following Membrane IgE Expression. CELL REPORTS 10:900-909(2015).
Wortmann, SB; Zietkiewicz, S; et al. CLPB Mutations Cause 3-Methylglutaconic Aciduria, Progressive Brain Atrophy, Intellectual Disability, Congenital Neutropenia, Cataracts, Movement Disorder. AMERICAN JOURNAL OF HUMAN GENETICS 96:245-257(2015).