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HAX1

  • Official Full Name

    HCLS1 associated protein X-1

  • Overview

    The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HAX1; HCLS1 associated protein X-1; HCLS1-associated protein X-1; HCLS1 (and PKD2) associated protein; HCLSBP1; HS1BP1; FLJ17042; FLJ18492; FLJ93803; HAX 1; Hax1a; HCLS1 and PKD2 associated protein; HCLS1 associated protein; HCLS1 associated protein X 1; HS 1 associated protein X 1; HS 1 binding protein; HS1 associating protein X 1; HS1 binding protein 1; HS1 binding protein; OTTHUMP00000034190; SCN3; HAX-1; HSP1BP-1; HS1-binding protein 1; HS1-associating protein X-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HAX1-4592H Recombinant Human HAX1 Protein, GST-tagged Wheat Germ GST
Human HAX1-7525H Recombinant Human HAX1, His-tagged E.coli His 1-279aa
Human HAX1-13677H Recombinant Human HAX1, GST-tagged E.coli GST 1-279a.a.
Human HAX1-29183TH Recombinant Human HAX1, His-tagged E.coli His
Human HAX1-5626HCL Recombinant Human HAX1 293 Cell Lysate HEK293 N/A
Human HAX1-5625HCL Recombinant Human HAX1 293 Cell Lysate HEK293 N/A
Human HAX1-3105H Recombinant Human HAX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HAX1-3489HF Recombinant Full Length Human HAX1 Protein, GST-tagged In Vitro Cell Free System GST 279 amino acids
Mouse Hax1-3362M Recombinant Mouse Hax1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat HAX1-2797R Recombinant Rat HAX1 Protein Mammalian Cell His
Rat HAX1-2452R Recombinant Rat HAX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HAX1-2452R-B Recombinant Rat HAX1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HAX1-2039R Recombinant Rhesus monkey HAX1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HAX1-1860R-B Recombinant Rhesus Macaque HAX1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HAX1-1860R Recombinant Rhesus Macaque HAX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HAX1-486Z Recombinant Zebrafish HAX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HAX1 Related Articles
  • HAX1 Related Research Area

HAX1 involved in several pathways and played different roles in them. We selected most pathways HAX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HAX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

HAX1 has several biochemical functions, for example, interleukin-1 binding, protein N-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAX1 itself. We selected most functions HAX1 had, and list some proteins which have the same functions with HAX1. You can find most of the proteins on our site.

Function Related Protein
interleukin-1 bindingTRIM16;A2M;HAX1
protein N-terminus bindingPARP1;PPP1CC;PIAS3;DAXX;PEX5;MECP2;GTF2H2;ERCC6;GTF2H3
protein bindingUSF2;PPP1R12B;BMPR1B;UNC45B;NUDT10;STIM1;C5orf20;GPS2;HMGB4

HAX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAX1.

vpr; TPCN2; MAPK10; ESR1; TPCN1; GRB7; a8k1f4_human; XPO1; Abcb11

Laffleur, B; Duchez, S; et al. Self-Restrained B Cells Arise following Membrane IgE Expression. CELL REPORTS 10:900-909(2015).
Wortmann, SB; Zietkiewicz, S; et al. CLPB Mutations Cause 3-Methylglutaconic Aciduria, Progressive Brain Atrophy, Intellectual Disability, Congenital Neutropenia, Cataracts, Movement Disorder. AMERICAN JOURNAL OF HUMAN GENETICS 96:245-257(2015).
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