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Official Full Name heat shock protein 90kDa alpha (cytosolic), class B member 1
Background HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding,;protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play;important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress.;There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive;form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM;606219) (Chen et al., 2005 (PubMed 16269234)).
Synonyms HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock 90kD protein 1, beta , heat shock 90kDa protein 1, beta , HSPC2, HSPCB; heat shock protein HSP 90-beta; heat shock 84 kDa; heat shock protein beta; heat shock 90kD protein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSP90AB1-016H Recombinant Human HSP90AB1 Protein, His-tagged E.coli His
    Mouse Hsp90ab1-1189M Recombinant Mouse Hsp90ab1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HSP90AB1-3859H Recombinant Human HSP90AB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HSP90AB1-135H Recombinant Human HSP90AB1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HSP90AB1-13979H Recombinant Human HSP90AB1, GST-tagged E.coli GST
    Human HSP90AB1-1462H Recombinant Human HSP90AB1, His-tagged Sf9 Insect Cell His
    Human HSP90AB1-1562H Recombinant Human HSP90AB1 protein E.coli N/A
    Human HSP90AB1-29404TH Recombinant Human HSP90AB1 N/A
    Human HSP90AB1-29405TH Recombinant Human HSP90AB1 N/A
    Human HSP90AB1-4924H Recombinant Human Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1 Sf9 Insect Cell N/A
    Human HSP90AB1-49H Recombinant Human HSP90AB1, His-tagged E.coli His
    Human HSP90AB1-5100H Recombinant Human HSP90AB1 Protein, GST-tagged Wheat Germ GST
    Human HSP90AB1-5361HCL Recombinant Human HSP90AB1 293 Cell Lysate HEK293 N/A
    Mouse HSP90AB1-7898M Recombinant Mouse HSP90AB1 Protein Mammalian Cell His
    Rat HSP90AB1-2940R Recombinant Rat HSP90AB1 Protein Mammalian Cell His
    Rhesus Macaque HSP90AB1-2161R Recombinant Rhesus monkey HSP90AB1 Protein, His-tagged Mammalian Cell His
    Chicken HSP90AB1-7098C Recombinant Chicken HSP90AB1 Mammalian Cell His
    Zebrafish HSP90AB1-8897Z Recombinant Zebrafish HSP90AB1 Mammalian Cell His

    HSP90AB1 involved in several pathways and played different roles in them. We selected most pathways HSP90AB1 participated on our site, such as Protein processing in endoplasmic reticulum, PIK-Akt signaling pathway, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSP90AB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum PKZ; SEC61G; HSP90AA1.2; RPN1; MAN1A; DNAJC5B; RAD23A; DAD1; P4HB; ATF4B1
    PIK-Akt signaling pathway FGF4; PPP2R2D; IL6; MDM2; TCL1; ATF4; GYS1; PIK3R2; LAMB1; ITGA1
    Antigen processing and presentation PSME1; HLA-DQA2; KIR3DL1; HSP90AB1; KIR2DS5; TAPBP; KLRC2; Ctsl; HLA-C; LGMN
    NOD-like receptor signaling pathway MAPK8; IL6; MAP3K7IP3; CXCL8B.3; IL8L1; CASP5; PSTPIP1; TAB2; MAPK12; MAPK13
    Progesterone-mediated oocyte maturation MAPK14A; MAPK14B; PIK3R1; CPEB4; CCNB2; FZR1A; AKT2L; PIK3R3A; PIK3R3B; IGF1
    Estrogen signaling pathway PIK3CD; FKBP5; KCNJ3; HSPA6; FOS; AKT2; GNAI3; CREB5; RAF1; CALML3
    Pathways in cancer APPL1; LAMA2; HSP90B1; Kitl; GNAI2; PML; Adcy4; GSK3B; CSF3R; PIK3R5
    Prostate cancer SPRY1; HSP90B1; MAPK3; NFKBIA; FOXA1; ARID1A; GRB2; SPINK1; KRAS; MDM2

    HSP90AB1 has several biochemical functions, for example, ATP binding, CTP binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSP90AB1 itself. We selected most functions HSP90AB1 had, and list some proteins which have the same functions with HSP90AB1. You can find most of the proteins on our site.

    Function Related Protein
    CTP binding HSP90AB1
    GTP binding GNAV1; DNM1B; GFM2; ARL4A; RAB38; GNA11B; TUBAL3; TUBB4B; RAB15; TUBG2
    MHC class II protein complex binding HSPA8; CD81; ATP1B1; HLA-DRB1; MS4A1; PKM; HSP90AB1; HLA-DOA; HSP90AA1; HLA-DMB
    TPR domain binding RAB8B; STUB1; PDE2A; HSP90AA1; HSP90AB1
    UTP binding MTPAP; HSP90AB1
    dATP binding ERCC3; ST13; HSP90AB1
    double-stranded RNA binding APTX; OAS1B; OAS2; STAU1; ILF3; OAS1; EIF2C3; DDX21; PRKRIP1; VIM
    ion channel binding AASS; ACTN2; PACS2; CALM3; CALM; ABCC9; RIMS1; NEDD4L; PRKCSH; RANGRF
    kinase binding RPS3; PIP5K1A; PFKL; NTRK1; CTNNB1; PRKCD; MOBKL1A; MIDN; RASGRP3; SLC2A1
    nitric-oxide synthase regulator activity AKT1; ESR1; CALM3; CALM1; HSP90AB1; HSP90AA1; HSP90AA1.1; CALM2
    poly(A) RNA binding FXR2; KIAA1324; CCDC108; H1FX; EIF5A; UBE2I; RIMS2; RPS20; FNDC3A; SRPK2
    protein binding RASSF3; DDX17; SPRR2A; UNC119; FAM71C; EMP1; TIMM8A; PUM1; FLG; TBRG1
    protein kinase binding TICAM1; FOXO3; MAPKAP1; PTPN23; PARP1; CACNB4; HSP90AB1; DLG1; FER; DUSP3
    sulfonylurea receptor binding KCNJ8; HSP90AB1
    unfolded protein binding HSPA5; PPIA; HSPD1; ST13; AHSP; SRSF12; CCT5; HSP90B1; DNAJB2; SSUH2RS1

    HSP90AB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSP90AB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSP90AB1.

    EGFR; CDC37; CDC37L1

    Sun, Y; Biscarini, F; et al. Genetic parameters and across-line SNP associations differ for natural antibody isotypes IgM and IgG in laying hens. ANIMAL GENETICS 44:413-424(2013).

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