HSP90AB1
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Official Full Name
heat shock protein 90kDa alpha (cytosolic), class B member 1
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Overview
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding,;protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play;important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress.;There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive;form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM;606219) (Chen et al., 2005 (PubMed 16269234)). -
Synonyms
HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock 90kD protein 1, beta , heat shock 90kDa protein 1, beta , HSPC2, HSPCB; heat shock protein HSP 90-beta; heat shock 84 kDa; heat shock protein beta; heat shock 90kD protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- HSP90AB1 Related Articles
HSP90AB1 involved in several pathways and played different roles in them. We selected most pathways HSP90AB1 participated on our site, such as Protein processing in endoplasmic reticulum, PIK-Akt signaling pathway, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSP90AB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein processing in endoplasmic reticulum | UBQLN1;LMAN1;HERPUD1;NFE2L2A;CAPN1;SEC24C;SELS;DNAJC5;UBE2D3 |
PIK-Akt signaling pathway | PIK3R3;PPP2R3C;RELA;IFNAR1;MAPK3;ITGB6;FGF1;GNG7;TEK |
Antigen processing and presentation | LGMN;TAP1;KIR2DS2;PSME2;RFXANK;HLA-DRB4;CD4;KLRC3;HSPA1L |
NOD-like receptor signaling pathway | Ccl12;TAB2;NLRP1;IL8L1;MAPK12A;CARD8;RIPK2;IL-8;IKBKG |
Progesterone-mediated oocyte maturation | CPEB1;CDK1;MAD2L2;FZR1A;RPS6KA1;CDC26;CDC25C;FZR1;RAF1A |
Estrogen signaling pathway | GPR30;CALML3;HSP90AB1;PIK3CG;GNAQ;CALM3;MAP2K2;GNAI3;HSPA6 |
Pathways in cancer | VEGFC;LAMA4;PTEN;PRKACB;PLEKHG5;FGF7;Pdgfa&Pdgfb;PRKCA;SMO |
Prostate cancer | MTOR;ERBB2;INS1;PIK3CG;ACTL6B;TGFA;HSP90B1;NDRG1;PIK3R3 |
HSP90AB1 has several biochemical functions, for example, ATP binding, CTP binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSP90AB1 itself. We selected most functions HSP90AB1 had, and list some proteins which have the same functions with HSP90AB1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | BMPR1AA;MYH1E;NLRC5;ATP1A1A.3;MAP4K2;EPHA10;WEE2;AK8;P2RX5 |
CTP binding | |
GTP binding | NME1;RAB15;RAB14;SEPT7;TUBD1;IRGF1;RRAS2;SEPT7A;ARL5C |
MHC class II protein complex binding | HSP90AB1;MS4A1;HLA-DMB;HSPA8;ATP1B1;HLA-DOB;HLA-DMA;YWHAE;PKM2 |
TPR domain binding | PDE2A;RAB8B;STUB1;HSP90AA1;HSP90AB1 |
UTP binding | MTPAP;HSP90AB1 |
dATP binding | ST13;HSP90AB1;ERCC3 |
double-stranded RNA binding | ZFP346;ILF3;RFTN1;MSN;OASL1;OAS1;TARBP2;OASL;ILF2 |
ion channel binding | YWHAQ;CHERP;HOMER1;SUMO1;FAM115A;CAV1;LRRK2;CIB1;DIAP1 |
kinase binding | CEBPB;CDC37;PARK2;DUSP12;HAP1;CEBPA;TNFAIP3;MOBKL1A;CHP |
nitric-oxide synthase regulator activity | CALM1;CALM3;AKT1;HSP90AA1.1;HSP90AA1;ESR1;CALM2;HSP90AB1 |
poly(A) RNA binding | PARP1;CPEB4;YTHDF3;IMP3;STRAP;MYH9;FASTKD5;CCDC55;MRPS12 |
protein binding | SPHK2;C1QTNF3;MYOC;POU2AF1;LSM6;LGALS14;RCN1;EDC4;HDAC1 |
protein kinase binding | AP2A2;KIF20A;USP37;BORA;KCNH1;CENPJ;VRK1;PIH1D1;TPCN2 |
sulfonylurea receptor binding | KCNJ8;HSP90AB1 |
unfolded protein binding | CALR3;GRPEL1;AHSP;DNAJA2L;CCT5;DNAJB1A;MKKS;ERO1LB;CDC37L1 |
HSP90AB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSP90AB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSP90AB1.
EGFR; CDC37; CDC37L1
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