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IFNL2

  • Official Full Name

    interferon, lambda 2

  • Overview

    IL-28A is a cytokine with immunomodulatory activity that up-regulates MHC class I antigen expression. Studies have shown that IL-28A displays potent antiviral activity in addition to antitumor activity. Ligand for the heterodimeric class II cytokine receptor is composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway and induce by viral infections or dsRNA. This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB), and interleukin 28 receptor, alpha (IL28RA).
  • Synonyms

    IL-28A; IL28A; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2; interferon-lambda 2; interleukin 28A (interferon, lambda 2); interleukin-28A;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|GST
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IFNL2-459H Active Recombinant Human IL28A protein, His-tagged Yeast His Val26-Val200
Human IFNL2-845H Active Recombinant Human IFNL2 Mammalian cells N/A
Human IFNL2-944H Active Recombinant Human IFNL2 Protein E.coli N/A
Human IFNL2-298H Recombinant Human IFNL2, StrepII-tagged Human Cell Strep II 26-200, 175 a.a.
Human IFNL2-7957H Recombinant Human IFNL2 N/A
Human IFNL2-466H Recombinant Human interferon, lambda 2, His-tagged E.coli His
Human IFNL2-5067H Recombinant Human IFNL2, His-tagged E.coli His
Human IFNL2-1806H Recombinant Human IFNL2 protein, His & GST-tagged E.coli His/GST Val26~Val200 (Accession # Q8IZJ0)
Human IFNL2-121H Recombinant Active Human IFNL2 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IFNL2-4426H Recombinant Human IFNL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IFNL2-4426H-B Recombinant Human IFNL2 Protein Pre-coupled Magnetic Beads HEK293
Human IFNL2-3814H Recombinant Human IFNL2 Protein (Met1-Val200), C-His tagged Mammalian cells C-His Met1-Val200
Human IFNL2-3687H Recombinant Human IFNL2 Protein (Val26-Val200), N-His tagged E.coli N-His Val26-Val200
Mouse Ifnl2-645M Active Recombinant Mouse Ifnl2, His-tagged Mammalian cells His
Mouse Ifnl2-01M Active Recombinant Mouse Ifnl2 Protein, His-Tagged E.coli His
Mouse Ifnl2-511M Active Recombinant Mouse Ifnl2 protein, His-tagged HEK293 His Met1-Val193
Mouse IFNL2-1077M Recombinant Mouse IFNL2 Protein E.coli N/A
Mouse Ifnl2-4446M Recombinant Mouse Ifnl2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ifnl2-145M Active Recombinant Mouse Ifnl2 Protein E.coli
Mouse Ifnl2-984M Recombinant Mouse Ifnl2 Protein, His-tagged CHO N-His Asp20-Val193
Mouse Ifnl2-122M Recombinant Active Mouse IFNL2 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Ifnl2-4446M-B Recombinant Mouse Ifnl2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IFNL2 Related Articles

IFNL2 involved in several pathways and played different roles in them. We selected most pathways IFNL2 participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Jak-STAT signaling pathwayIfnl2;TP-1;IL13;IFNPHI1;IL19;PTPN11A;IL12B;IL27RA;IFNAR1

IFNL2 has several biochemical functions, for example, cytokine activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNL2 itself. We selected most functions IFNL2 had, and list some proteins which have the same functions with IFNL2. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTNF;IFNA16;IFNA8;INHBA;C1QTNF4;TNFSF4;IFNPHI2;Fasl;GDF5
receptor bindingPTK2AB;HFE2;PVRL1A;PANX1;LTB;FGF8A;TAC3;WNT7AA;LBP

IFNL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNL2.

Egli, A; Santer, DM; et al. IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza. PLOS PATHOGENS 10:-(2014).
Guedj, J; Rotman, Y; et al. Understanding Early Serum Hepatitis D Virus and Hepatitis B Surface Antigen Kinetics During Pegylated Interferon-alpha Therapy Via Mathematical Modeling. HEPATOLOGY 60:1902-1910(2014).
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