ifnl2
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  • Official Full Name
  • interferon, lambda 2
  • Background
  • IL-28A is a cytokine with immunomodulatory activity that up-regulates MHC class I antigen expression. Studies have shown that IL-28A displays potent antiviral activity in addition to antitumor activity. Ligand for the heterodimeric class II cytokine receptor is composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway and induce by viral infections or dsRNA. This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB), and interleukin 28 receptor, alpha (IL28RA).
  • Synonyms
  • IL-28A; IL28A; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon lambda-2; interferon-lambda 2; interleukin 28A (interferon, lambda 2); interleukin-28A
Cat.#:IFNL2-1077MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IFNL2 Protein
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Cat.#:IFNL2-1806HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNL2 protein, His & GST-tagged
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Cat.#:IFNL2-298HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNL2, StrepII-tagged
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Cat.#:IFNL2-459HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNL2 Protein, His-tagged
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Cat.#:IFNL2-466HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human interferon, lambda 2, His-tagged
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Cat.#:IFNL2-5067HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNL2, His-tagged
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Cat.#:IFNL2-7957HTag:
Source (Host):Species:Human
Product nameRecombinant Human IFNL2
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Cat.#:IFNL2-845HTag:
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human IFNL2
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Cat.#:IFNL2-944HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNL2 Protein
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Cat.#:Ifnl2-511MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifnl2, His-tagged
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Cat.#:Ifnl2-645MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Ifnl2, His-tagged
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Involved Pathway

IFNL2 involved in several pathways and played different roles in them. We selected most pathways IFNL2 participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Jak-STAT signaling pathway
PTPN2B; SOCS6; SOCS9; CRLF2; IL13; CNTFR; SOCS4; Il2; TP-1; SOCS7

Protein Function

IFNL2 has several biochemical functions, for example, cytokine activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNL2 itself. We selected most functions IFNL2 had, and list some proteins which have the same functions with IFNL2. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IFNG1-2; IL9; GREM1; IL10; CMTM4; BMP2B; CCL38.1; CCL38A.5; Il1f8; IL17B
Function receptor binding
Related Protein ALCAM; NPPA; ABL1; TNFSF14; ABL2; HIST2H3C2; CADM2A; CCDC129; NOS2; SCYL2

IFNL2 Related Articles

Egli, A; Santer, DM; et al. IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza. PLOS PATHOGENS 10:-(2014).
Guedj, J; Rotman, Y; et al. Understanding Early Serum Hepatitis D Virus and Hepatitis B Surface Antigen Kinetics During Pegylated Interferon-alpha Therapy Via Mathematical Modeling. HEPATOLOGY 60:1902-1910(2014).