IRF4
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Official Full Name
interferon regulatory factor 4 -
Overview
The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease. -
Synonyms
IRF4;interferon regulatory factor 4;MUM1;LSIRF;multiple myeloma oncogene 1;lymphocyte-specific interferon regulatory factor;NF-EM5
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- GST
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
IRF4 involved in several pathways and played different roles in them. We selected most pathways IRF4 participated on our site, such as Apoptosis,Calcineurin-regulated NFAT-dependent transcription in lymphocytes,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Interferon gamma signaling | TRIM22,TRIM6,TRIM10,TRIM5,GBP5,GBP4,TRIM8,FCGR1B,TRIM38,HLA-DQB2 |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | EGR1,JUNB,EGR4,DGKA,POU2F1,CSF2,IKZF1,CTLA4,EGR2,EGR3 |
| Interferon alpha/beta signaling | IFI35,IFITM2,OASL,IRF6,IFIT3,IRF2,SAMHD1,IRF9,BST2,GBP2 |
| Cytokine Signaling in Immune system | IFI30,MARK3,KLB,SPTBN2,KPNA4,CSF2RB,SPRED1,CNKSR1,SPRED3,KPNA5 |
| IL4-mediated signaling events | CCL26,IgG3,PARP14,NIPAL1,RETNLB,MYB,MYBL1,TFF3,EGR2,DOK2 |
| Interferon Signaling | TRIM26,IFI30,SAMHD1,MX2,TRIM62,IFIT14,TRIM38,HLA-DQB2,TRIM14,TRIM17 |
| Immune System | CD300LD,NA,POLR3GLA,POLR3G,CLEC2B,PJA1,TIRAP,BTR12,FCN1,LILRA3 |
| Apoptosis | PLEC,STK26,BCAP31,PIK3R3,IRF2,CASP6L1,DCC,BAXB,HIST1H1A,IRF2A |
Protein Function
IRF4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,protein-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF4 itself. We selected most functions IRF4 had, and list some proteins which have the same functions with IRF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CARF,SIX4,SOX11,MEF2C,HOXC13,TRP53,CRX,ELF1,GCM1,SRF |
| transcription factor binding | STK4,RPS3,GPX3,TAF12,MAFB,DRG1,CREG1,MAPK1,MED12,IFI16 |
| sequence-specific DNA binding | RXRGA,CENPB,ZNF394,SALL2,LHX6,TCF7L1B,POUV,IRX2A,FOXI1,SOX21A |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NFE2L3,FOXJ1,NFATC2,ZNF92,E2F8,CREB3L2,JUNBA,Ar,POU4F2,NCOA2 |
| protein binding | SPC25,CDK6,GFI1B,EYA3,UBL5,NUCB1,NFYB,STOX1,NCF2,LINGO1 |
| transcription factor activity, sequence-specific DNA binding | FOXO4,PHF5A,ZSCAN20,IKZF1,ARNT,POU2F1B,EF1,HER5,ZNF238,EGR2B |
| protein-lysine N-methyltransferase activity | TRMT10C,METTL21A,SETD4,METTL7B,PRDM12,SMYD2,FAM86A,NDUFAF5,PRMT8B,EHMT1 |
Interacting Protein
IRF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF4.
IKBKAP;IRAK1;TLK2;YTHDC2;TRAF2;sSL2;caspa_human_gene;cflar_human_gene;PEG10;CARM1;VPS35;BAT2L
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References
- Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
- White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).
