IRF4

  • Official Full Name

    interferon regulatory factor 4
  • Overview

    The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease.
  • Synonyms

    IRF4;interferon regulatory factor 4;MUM1;LSIRF;multiple myeloma oncogene 1;lymphocyte-specific interferon regulatory factor;NF-EM5

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • T7
  • Non
  • GST
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
IRF4-106H Recombinant Human IRF4 Protein, N-His tagged E.coli Human His 1-451 aa
IRF4-105H Recombinant Human IRF4 protein, T7/His-tagged E.coli Human His&T7
IRF4-142H Recombinant Human Human Interferon Regulatory Factor 4 E.coli Human Non 144-451 a.a.
Irf4-1749M Recombinant Mouse Irf4 protein, His & T7-tagged E.coli Mouse His&T7 Asp175~His433
IRF4-2298R Recombinant Rhesus monkey IRF4 Protein, His-tagged Mammalian Cells Rhesus macaque His
IRF4-28543TH Recombinant Human IRF4 E.coli Human Non 144-451 a.a.
IRF4-5872C Recombinant Chicken IRF4 Mammalian Cells Chicken His
IRF4-726H Recombinant Human IRF4 Protein, GST-His-tagged E.coli Human GST&His
IRF4-5165HCL Recombinant Human IRF4 293 Cell Lysate HEK293 Human Non
IRF4-1197H Recombinant Human IRF4 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IRF4-1197H-B Recombinant Human IRF4 Protein Pre-coupled Magnetic Beads HEK293 Human
IRF4-2119R Recombinant Rhesus Macaque IRF4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IRF4-2119R-B Recombinant Rhesus Macaque IRF4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IRF4-2889H Recombinant Human IRF4 Protein (Glu130-Glu451), N-His tagged E.coli Human His Glu130-Glu451
IRF4-3565H Recombinant Human IRF4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Irf4-3575M Recombinant Mouse Irf4 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
IRF4-404HFL Recombinant Full Length Human IRF4 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
IRF4-5039H Recombinant Human IRF4 Protein, GST-tagged Wheat Germ Human GST
IRF4-5739HF Recombinant Full Length Human IRF4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 451 amino acids

    Involved Pathway

    IRF4 involved in several pathways and played different roles in them. We selected most pathways IRF4 participated on our site, such as Apoptosis,Calcineurin-regulated NFAT-dependent transcription in lymphocytes,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    IL4-mediated signaling events EGR2,CCL26,RETNLB,TFF3,MYBL1,NIPAL1,MYB,DOK2,IgG3,PARP14
    Cytokine Signaling in Immune system TRIM62,TRIM3,RASGEF1A,CSF2,FGF10B,NOD1,SPNA1,USP18,KLB,MX2
    Apoptosis STK26,PIK3R1,DAPK3,PIK3R3A,CFLAR,IRAK4,DERL3,CASP9,AKT3A,CSF2RB
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes JUNB,POU2F1,EGR1,IKZF1,BATF3,EGR2,CTLA4,EGR4,EGR3,CSF2
    Interferon gamma signaling TRIM6,GBP2,FCGR1B,IFI30,TRIM29,TRIM26,TRIM3,TRIM46,GBP5,TRIM68
    Interferon Signaling TRIM26,GBP5,HERC5,TRIM68,GBP1,ARIH1L,IFIT10,IFIT8,TRIM14,IFI6
    Interferon alpha/beta signaling OASL,IFI27,GBP2,MX2,IFI35,IFIT2,IFITM2,BST2,IFIT3,XAF1
    Immune System KIF2B,SUGT1,EDARADD,IFIT2,CTSB,FAM49BA,DEFB106A,KLRB1F,GAN,ARIH1L

    Protein Function

    IRF4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,protein-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF4 itself. We selected most functions IRF4 had, and list some proteins which have the same functions with IRF4. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NKX6,HELT,CEBPG,MYPOP,MAFB,IFI16,MED1,ZNF543,EBF2,DPF2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding STK16,SMAD4,MITF,CEBPE,NKX2,SFPI1,ZNF750,EGR2,ONECUTL,HIF1A
    transcription factor binding PARK7,DR1,AGTR2,RELA,HMGB1,KEAP1B,TFDP1B,TP53,TRERF1,NFKB1
    protein binding CACNG2,DDX3X,RPL4,VDR,SAMHD1,BBS10,CRH,STYK1,GTF3C4,SALL2
    transcription factor activity, sequence-specific DNA binding FOXQ1B,POU2F1,ASCL1B,GATA3,ZFP367,CREBZF,ETV6,EGR2,PBX1A,ESRRGB
    sequence-specific DNA binding HOXB6A,LHX8A,LHX2B,NR6A1B,ZNF323,IKZF4,FOXC1B,EVX2,DRGX,LHX4
    protein-lysine N-methyltransferase activity METTL8,PRDM12,SETD8,AAAS,SMYD2A,METTL23,FBLL1,METTL20,RNMTL1B,NDUFAF5

    Interacting Protein

    IRF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF4.

    IKBKAP;IRAK1;TLK2;YTHDC2;TRAF2;sSL2;caspa_human_gene;cflar_human_gene;PEG10;CARM1;VPS35;BAT2L

    Resources

    References

    • Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
    • White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).

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