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Official Full Name interferon regulatory factor 4
Background The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease.
Synonyms IRF4; interferon regulatory factor 4; MUM1; LSIRF; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; NF-EM5
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRF4-105H Recombinant Human IRF4 protein, T7/His-tagged E.coli T7/His
    Human IRF4-142H Recombinant Human Human Interferon Regulatory Factor 4 E.coli N/A
    Human IRF4-28543TH Recombinant Human IRF4 E.coli N/A
    Human IRF4-5039H Recombinant Human IRF4 Protein, GST-tagged Wheat Germ GST
    Human IRF4-5165HCL Recombinant Human IRF4 293 Cell Lysate HEK293 N/A
    Human IRF4-726H Recombinant Human IRF4 Protein, GST-His-tagged E.coli GST/His
    Mouse Irf4-1749M Recombinant Mouse Irf4 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque IRF4-2298R Recombinant Rhesus monkey IRF4 Protein, His-tagged Mammalian Cell His
    Chicken IRF4-5872C Recombinant Chicken IRF4 Mammalian Cell His

    IRF4 involved in several pathways and played different roles in them. We selected most pathways IRF4 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes IKZF1; POU2F1; BATF3; DGKA; EGR1; CDK4; JUNB; IRF4; CTLA4; CSF2
    Cytokine Signaling in Immune system CSF2RB; XAF1; IL1RN; TRIM6; NUP35; PEA15; PEBP1; IRF4; WDR83; IFIT14
    IL4-mediated signaling events IRF4; PARP14; IgG3; TFF3; EGR2; MYBL1; CCL26; DOK2; MYB; NIPAL1
    Immune System TRIM45; RNF138; KIF26A; UBE2E3; KLRB1B; IFIT2; CFHL2; TXNIPB; FCN3; CD300LB
    Interferon Signaling TRIM29; IFI35; USP18; EIF4G2; TRIM8; HERC5; IRF6; GBP6; MX2; TRIM45
    Interferon alpha/beta signaling IRF9; MX2; ISG20; USP18; IFI27; IRF2; GBP2; IFI6; IFITM2; IFIT3
    Interferon gamma signaling TRIM14; TRIM6; GBP4; TRIM5; TRIM68; TRIM46; FCGR1B; TRIM8; TRIM3; TRIM31

    IRF4 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF4 itself. We selected most functions IRF4 had, and list some proteins which have the same functions with IRF4. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding CTCF; RBPJA; POU4F2; RFX2; MITF; CREB1; AGO1; FOXK2; POU2F3; RBPJB
    protein binding UBE3A; NUMBL; TMEM132D; PSMB2; CCDC137; KIF3A; HSP90AA1; PRMT5; SENP7; SOCS1
    protein-lysine N-methyltransferase activity SMYD2B; DIMT1; PRMT8B; EHMT1; SETD8; METTL23; METTL21A; FAM119A; IRF4; SMYD2
    sequence-specific DNA binding DLX5A; NKX2.5; LHX2B; NCOR1; HOXC8; NR4A2A; GRHL2; OTPA; FOXL1; FOXO3B
    transcription factor activity, sequence-specific DNA binding ZFHX3; GTF2H2; MAFBA; SOX11A; HMGA1; PGBD1; PRDM1A; ZNF263; SPIB; ATF6B
    transcription factor binding NFATC4; CREG1; PAX2; NFIA; NR0B2; HES2; WWP2; AIP; HMGA2; TCF7L2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding KLF4; SIX1; SOX12; SMAD4; NR5A2; TCF21; MITFB; ONECUT3; TRP63; POU4F1

    IRF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF4.

    IKBKAP; IRAK1; TLK2; YTHDC2; TRAF2; sSL2; caspa_human_gene; cflar_human_gene; PEG10; CARM1; VPS35; BAT2L

    Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
    White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).

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