irf4
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  • Official Full Name
  • interferon regulatory factor 4
  • Background
  • The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease.
  • Synonyms
  • IRF4; interferon regulatory factor 4; MUM1; LSIRF; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; NF-EM5
Cat.#:IRF4-5039HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF4 Protein, GST-tagged
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Cat.#:IRF4-105HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF4 protein, T7/His-tagged
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Cat.#:IRF4-142HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Human Interferon Regulatory Factor 4
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Cat.#:IRF4-28543THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF4
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Cat.#:IRF4-726HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF4 Protein, GST-His-tagged
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Cat.#:Irf4-1749MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irf4 protein, His & T7-tagged
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Cat.#:IRF4-2298RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF4 Protein, His-tagged
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Cat.#:IRF4-5872CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRF4
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Cat.#:IRF4-5165HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF4 293 Cell Lysate
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Involved Pathway

IRF4 involved in several pathways and played different roles in them. We selected most pathways IRF4 participated on our site, such as Apoptosis, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
NGF; Gzmg; TP53; CASP6L2; CASP10; HELLS; BCL2L1; PPP3R1; CYCSB; PRKAR2B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
EGR4; IKZF1; EGR3; CSF2; POU2F1; EGR2; IRF4; CDK4; DGKA; CTLA4
Cytokine Signaling in Immune system
TRIM8; IFIT12; TNFSF13B; IFITM2; DUSP9; IFITM3; PRLRB; IFI30; IFIT2; SPNA1
IL4-mediated signaling events
EGR2; NIPAL1; CCL26; MYB; IgG3; PARP14; DOK2; MYBL1; RETNLB; TFF3
Immune System
CD300LB; SIGLEC9; IFI16; SPSB1; FCN3; CLEC2B; BTR16; UBR1; CNPY3; ASB11
Interferon Signaling
ISG20; EIF4G2; IFIT14; GBP2; IFIT8; IFI30; OASL; IRF4; TRIM8; TRIM5
Interferon alpha/beta signaling
IRF4; IRF9; SAMHD1; GBP2; IFI6; IFI35; IFITM2; ISG20; BST2; IFITM3
Interferon gamma signaling
TRIM31; TRIM6; GBP6; TRIM10; TRIM2; TRIM17; GBP1; TRIM48; TRIM8; IRF4

Protein Function

IRF4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, protein-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF4 itself. We selected most functions IRF4 had, and list some proteins which have the same functions with IRF4. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein RFX3; MED8; NKX6; CUX2; ONECUT2; ZNF264; EHF; ZNF718; MYBL1; KLF13
Function protein binding
Related Protein APPB; PAK3; NLRP1; PCSK9; NCF2; EPO; GNG4; FKBP4; CRMP1; MYL12B
Function protein-lysine N-methyltransferase activity
Related Protein RNMTL1A; SETD7; PRMT8B; TRMT10C; AAAS; PRDM11; RNMTL1B; METTL21D; VCPKMT; METTL20
Function sequence-specific DNA binding
Related Protein HOXA5A; HOXC12B; POU2F3; HSFY1; MSXE; PHOX2BB; HOXC10; ZSCAN4; GCM2; RX2
Function transcription factor activity, sequence-specific DNA binding
Related Protein NFE2L1A; UBN2A; ZNF461; EFCAB11; DMBX1; CREB1B; HOXD4; TFDP2; SALL3; ZFP322A
Function transcription factor binding
Related Protein PSMC5; FHL2; HMGB2; RPS3; PPP1R13BB; PARP1; SIX2; SOST; HES6; PRKDC
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CEBPG; NCOA3; GATA1; MYC; CREB3; SMAD1; FOXD1; ZFAT; STK16; TFE3

Interacting Protein

IRF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF4.
IKBKAP; IRAK1; TLK2; YTHDC2; TRAF2; sSL2; caspa_human_gene; cflar_human_gene; PEG10; CARM1; VPS35; BAT2L

IRF4 Related Articles

Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).