| Official Full Name | interferon regulatory factor 4 |
| Background | The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease. |
| Synonyms | IRF4; interferon regulatory factor 4; MUM1; LSIRF; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; NF-EM5 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
IRF4 involved in several pathways and played different roles in them. We selected most pathways IRF4 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | CASP9; IRAK4; PPP3CC; IL1A; BIDA; BAXB; TNFRSF10A; CASP2; DIABLOA; PPP3R1 |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | IKZF1; POU2F1; BATF3; DGKA; EGR1; CDK4; JUNB; IRF4; CTLA4; CSF2 |
| Cytokine Signaling in Immune system | CSF2RB; XAF1; IL1RN; TRIM6; NUP35; PEA15; PEBP1; IRF4; WDR83; IFIT14 |
| IL4-mediated signaling events | IRF4; PARP14; IgG3; TFF3; EGR2; MYBL1; CCL26; DOK2; MYB; NIPAL1 |
| Immune System | TRIM45; RNF138; KIF26A; UBE2E3; KLRB1B; IFIT2; CFHL2; TXNIPB; FCN3; CD300LB |
| Interferon Signaling | TRIM29; IFI35; USP18; EIF4G2; TRIM8; HERC5; IRF6; GBP6; MX2; TRIM45 |
| Interferon alpha/beta signaling | IRF9; MX2; ISG20; USP18; IFI27; IRF2; GBP2; IFI6; IFITM2; IFIT3 |
| Interferon gamma signaling | TRIM14; TRIM6; GBP4; TRIM5; TRIM68; TRIM46; FCGR1B; TRIM8; TRIM3; TRIM31 |
IRF4 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF4 itself. We selected most functions IRF4 had, and list some proteins which have the same functions with IRF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CTCF; RBPJA; POU4F2; RFX2; MITF; CREB1; AGO1; FOXK2; POU2F3; RBPJB |
| protein binding | UBE3A; NUMBL; TMEM132D; PSMB2; CCDC137; KIF3A; HSP90AA1; PRMT5; SENP7; SOCS1 |
| protein-lysine N-methyltransferase activity | SMYD2B; DIMT1; PRMT8B; EHMT1; SETD8; METTL23; METTL21A; FAM119A; IRF4; SMYD2 |
| sequence-specific DNA binding | DLX5A; NKX2.5; LHX2B; NCOR1; HOXC8; NR4A2A; GRHL2; OTPA; FOXL1; FOXO3B |
| transcription factor activity, sequence-specific DNA binding | ZFHX3; GTF2H2; MAFBA; SOX11A; HMGA1; PGBD1; PRDM1A; ZNF263; SPIB; ATF6B |
| transcription factor binding | NFATC4; CREG1; PAX2; NFIA; NR0B2; HES2; WWP2; AIP; HMGA2; TCF7L2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | KLF4; SIX1; SOX12; SMAD4; NR5A2; TCF21; MITFB; ONECUT3; TRP63; POU4F1 |
IRF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF4.
IKBKAP; IRAK1; TLK2; YTHDC2; TRAF2; sSL2; caspa_human_gene; cflar_human_gene; PEG10; CARM1; VPS35; BAT2L
