Recombinant Full Length Human IRF4 Protein, C-Flag-tagged

• Cat.No.: IRF4-404HFL
• Product Overview: Recombinant Full Length Human IRF4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 51.6 kDa
• AA Sequence: MNLEGGGRGGEFGMSAVSCGNGKLR QWLIDQIDSGKYPGLVWENEEKSIF RIPWKHAGKQDYNREEDAAL FKAWALFKGKFREGIDKPDPPTWKT RLRCALNKSNDFEELVERSQLDISD PYKVYRIVPEGAKKGAKQLT LEDPQMSMSHPYTMTTPYPSLPAQQ VHNYMMPPLDRSWRDYVPDQPHPEI PYQCPMTFGPRGHHWQGPAC ENGCQVTGTFYACAPPESQAPGVPT EPSIRSAEALAFSDCRLHICLYYRE ILVKELTTSSPEGCRISHGH TYDASNLDQVLFPYPEDNGQRKNIE KLLSHLERGVVLWMAPDGLYAKRLC QSRIYWDGPLALCNDRPNKL ERDQTCKLFDTQQFLSELQAFAHHG RSLPRFQVTLCFGEEFPDPQRQRKL ITAHVEPLLARQLYYFAQQN
  SGHFLRGYDLPEHISNPEDYHRSIR HSSIQETRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: IRF4 interferon regulatory factor 4 [ Homo sapiens (human) ]
• Official Symbol: IRF4
• Synonyms: MUM1; LSIRF; SHEP8; NF-EM5
• Gene ID: 3662
• mRNA Refseq: NM_002460.4
• Protein Refseq: NP_002451.2
• MIM: 601900
• UniProt ID: Q15306