This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
Grassot, V; Da Silva, A; et al. Highlights of glycosylation and adhesion related genes involved in myogenesis. BMC GENOMICS 15:-(2014).
Kaltz, N; Ringe, J; et al. Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources. EXPERIMENTAL CELL RESEARCH 316:2609-2617(2010).
Barczyk, MM; Olsen, LHB; et al. A Role for alpha 11 beta 1 Integrin in the Human Periodontal Ligament. JOURNAL OF DENTAL RESEARCH 88:621-626(2009).