Recombinant Full Length Human ITGA11 Protein, C-Flag-tagged

• Cat.No.: ITGA11-1532HFL
• Product Overview: Recombinant Full Length Human ITGA11 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 131 kDa
• AA Sequence: MDLPRGLVVAWALSLWPGFTDTFNM DTRKPRVIPGSRTAFFGYTVQQHDI SGNKWLVVGAPLETNGYQKT GDVYKCPVIHGNCTKLNLGRVTLSN VSERKDNMRLGLSLATNPKDNSFLA CSPLWSHECGSSYYTTGMCS RVNSNFRFSKTVAPALQRCQTYMDI VIVLDGSNSIYPWVEVQHFLINILK KFYIGPGQIQVGVVQYGEDV VHEFHLNDYRSVKDVVEAASHIEQR GGTETRTAFGIEFARSEAFQKGGRK GAKKVMIVITDGESHDSPDL EKVIQQSERDNVTRYAVAVLGYYNR RGINPETFLNEIKYIASDPDDKHFF NVTDEAALKDIVDALGDRIF SLEGTNKNETSFGLEMSQTGFSSHV VEDGVLLGAVGAYDWNGAVLKETSA GKVIPLRESYLKEFPEELKN HGAYLGYTVTSVVSSRQGRVYVAGA PRFNHTGKVILFTMHNNRSLTIHQA MRGQQIGSYFGSEITSVDID GDGVTDVLLVGAPMYFNEGRERGKV YVYELRQNLFVYNGTLKDSHSYQNA RFGSSIASVRDLNQDSYNDV VVGAPLEDNHAGAIYIFHGFRGSIL KTPKQRITASELATGLQYFGCSIHG QLDLNEDGLIDLAVGALGNA VILWSRPVVQINASLHFEPSKINIF HRDCKRSGRDATCLAAFLCFTPIFL APHFQTTTVGIRYNATMDER RYTPRAHLDEGGDRFTNRAVLLSSG QELCERINFHVLDTADYVKPVTFSV EYSLEDPDHGPMLDDGWPTT LRVSVPFWNGCNEDEHCVPDLVLDA RSDLPTAMEYCQRVLRKPAQDCSAY TLSFDTTVFIIESTRQRVAV EATLENRGENAYSTVLNISQSANLQ FASLIQKEDSDGSIECVNEERRLQK QVCNVSYPFFRAKAKVAFRL DFEFSKSIFLHHLEIELAAGSDSNE RDSTKEDNVAPLRFHLKYEADVLFT RSSSLSHYEVKPNSSLERYD GIGPPFSCIFRIQNLGLFPIHGMMM KITIPIATRSGNRLLKLRDFLTDEA NTSCNIWGNSTEYRPTPVEE DLRRAPQLNHSNSDVVSINCNIRLV PNQEINFHLLGNLWLRSLKALKYKS MKIMVNAALQRQFHSPFIFR EEDPSRQIVFEISKQEDWQVPIWII VGSTLGGLLLLALLVLALWKLGFFR SARRRREPGLDPTPKVLETRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton

Gene Information

• Gene Name: ITGA11 integrin subunit alpha 11 [ Homo sapiens (human) ]
• Official Symbol: ITGA11
• Synonyms: HsT18964
• Gene ID: 22801
• mRNA Refseq: NM_001004439.2
• Protein Refseq: NP_001004439.1
• MIM: 604789
• UniProt ID: Q9UKX5