itgb4
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  • Official Full Name
  • integrin, beta 4
  • Background
  • CD104 is a 205 kD type I transmembrane glycoprotein, known as integrin beta4 chain or beta4 integrin, that associates with integrin alpha6 (CD49f) forms alpha6/beta4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the prol
  • Synonyms
  • ITGB4; integrin, beta 4; integrin beta-4; CD104; GP150; CD104 antigen; integrin beta-4 subunit
Cat.#:ITGB4-2739RTag:His-SUMO
Source (Host):E. coli Cell FreeSpecies:Rat
Product nameRecombinant Rat ITGB4 Protein (28-713 aa), His-SUMO-tagged
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Cat.#:ITGB4-2650HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGB4 Protein, MYC/DDK-tagged
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Cat.#:ITGB4-4972HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGB4 Protein, GST-tagged
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Cat.#:ITGB4-181HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB4, GST-tagged
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Cat.#:ITGB4-6964HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB4 protein, His & T7-tagged
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Cat.#:Itgb4-6965MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itgb4 protein, His & T7-tagged
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Cat.#:ITGB4-3116RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITGB4 Protein
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Cat.#:ITGB4-2993ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ITGB4
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Involved Pathway

ITGB4 involved in several pathways and played different roles in them. We selected most pathways ITGB4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
IGF1R; GNB4; TLR4; GHR; ITGB4; ITGA6; COL24A1; CD19; PDGFD; TSC1
Focal adhesion
MYLK4; MYLK; TNN; TLN1; FIGF; MAPK1; ROCK1; RAF1; ITGA2; VEGFB
ECM-receptor interaction
THBS3; TNN; ITGB4; GP6; THBS4A; Itga10&Itgb1; COL24A1; FN1; Npnt; CHAD
Regulation of actin cytoskeleton
PFN3; ITGAE; BRAF; FGF6; ARAF; ABI2A; APC; VAV1; SRC; PAK6B
Hypertrophic cardiomyopathy (HCM)
DAG1; CACNG6; SLC8A1; IGF1; ITGA1; CACNG7; CACNG8; CACNA2D3; PRKAB2; ITGB7
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGA2B; JUP; CTNNA3; CACNA2D2; ITGA5; ITGA7; DMD; SGCD; CACNG8; SLC8A1
Dilated cardiomyopathy
PLN; PRKACG; CACNG8; LAMA2; CACNB1; MYL3; ITGA2; ITGA5; ITGB7; ITGB8

Protein Function

ITGB4 has several biochemical functions, for example, G-protein coupled receptor binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB4 itself. We selected most functions ITGB4 had, and list some proteins which have the same functions with ITGB4. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor binding
Related Protein ITGB4; S1PR1; GPRC5B; PARK2; GNA13B; PSAPL1; NPFFL; HSPA8; GNA12A; UCN2
Function protein binding
Related Protein DDA1; ADD1; RPS10; PHF1; MLLT4; TAF1B; POLR1C; PRPS2; SEPT9; PDIA2
Function receptor activity
Related Protein STRA6; EIF2D; CSF3R; NCR3; CD200R3; PAQR3B; MED24; TIGIT; PAQR5A; MED14

Interacting Protein

ITGB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB4.
PLEC; ITGA6; Cadm1; S1PR3; ARRDC3

ITGB4 Related Articles

Chen, YH; Chang, SH; et al. The mechanism for keratinocyte detaching from pH-responsive chitosan. BIOMATERIALS 35:9247-9254(2014).
Chen, Q; Xu, R; et al. Down-Regulation of Gli Transcription Factor Leads to the Inhibition of Migration and Invasion of Ovarian Cancer Cells via Integrin beta 4-Mediated FAK Signaling. PLOS ONE 9:-(2014).