| Description : |
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
202.12 kDa |
| AA Sequence : |
MAGPRPSPWARLLLAALISVSLSGT LANRCKKAPVKSCTECVRVDKDCAY CTDEMFRDRRCNTQAELLAAGCQRE SIVVMESSFQITEETQIDTTLRRSQ MSPQGLRVRLRPGEERHFELEVFEP LESPVDLYILMDFSNSMSDDLDNLK KMGQNLARVLSQLTSDYTIGFGKFV DKVSVPQTDMRPEKLKEPWPNSDPP FSFKNVISLTEDVDEFRNKLQGERI SGNLDAPEGGFDAILQTAVCTRDIG WRPDSTHLLVFSTESAFHYEADGAN VLAGIMSRNDERCHLDTTGTYTQYR TQDYPSVPTLVRLLAKHNIIPIFAV TNYSYSYYEKLHTYFPVSSLGVLQE DSSNIVELLEEAFNRIRSNLDIRAL DSPRGLRTEVTSKMFQKTRTGSFHI RRGEVGIYQVQLRALEHVDGTHVCQ LPEDQKGNIHLKPSFSDGLKMDAGI ICDVCTCELQKEVRSARCSFNGDFV CGQCVCSEGWSGQTCNCSTGSLSDI QPCLREGEDKPCSGRGECQCGHCVC YGEGRYEGQFCEYDNFQCPRTSGFL CNDRGRCSMGQCVCEPGWTGPSCDC PLSNATCIDSNGGICNGRGHCECGR CHCHQQSLYTDTICEINYSAIHPGL CEDLRSCVQCQAWGTGEKKGRTCEE CNFKVKMVDELKRAEEVVVRCSFRD EDDDCTYSYTMEGDGAPGPNSTVLV HKKKDCPPGSFWWLIPLLLLLLPLL ALLLLLCWKYCACCKACLALLPCCN RGHMVGFKEDHYMLRENLMASDHLD TPMLRSGNLKGRDVVRWKVTNNMQR PGFATHAASINPTELVPYGLSLRLA RLCTENLLKPDTRECAQLRQEVEEN LNEVYRQISGVHKLQQTKFRQQPNA GKKQDHTIVDTVLMAPRSAKPALLK LTEKQVEQRAFHDLKVAPGYYTLTA DQDARGMVEFQEGVELVDVRVPLFI RPEDDDEKQLLVEAIDVPAGTATLG RRLVNITIIKEQARDVVSFEQPEFS VSRGDQVARIPVIRRVLDGGKSQVS YRTQDGTAQGNRDYIPVEGELLFQP GEAWKELQVKLLELQEVDSLLRGRQ VRRFHVQLSNPKFGAHLGQPHSTTI IIRDPDELDRSFTSQMLSSQPPPHG DLGAPQNPNAKAAGSRKIHFNWLPP SGKPMGYRVKYWIQGDSESEAHLLD SKVPSVELTNLYPYCDYEMKVCAYG AQGEGPYSSLVSCRTHQEVPSEPGR LAFNVVSSTVTQLSWAEPAETNGEI TAYEVCYGLVNDDNRPIGPMKKVLV DNPKNRMLLIENLRESQPYRYTVKA RNGAGWGPEREAIINLATQPKRPMS IPIIPDIPIVDAQSGEDYDSFLMYS DDVLRSPSGSQRPSVSDDTGCGWKF EPLLGEELDLRRVTWRLPPELIPRL SASSGRSSDAEAPHGPPDDGGAGGK GGSLPRSATPGPPGEHLVNGRMDFA FPGSTNSLHRMTTTSAAAYGTHLSP HVPHRVLSTSSTLTRDYNSLTRSEH SHSTTLXRDYSTLTSVSSHDSRLTA GVPDTPTRLVFSALGPTSLRVSWQE PRCERPLQGYSVEYQLLNGGELHRL NIPNPAQTSVVVEDLLPNHSYVFRV RAQSQEGWGREREGVITIESQVHPQ SPLCPLPGSAFTLSTPSAPGPLVFT ALSPDSLQLSWERPRRPNGDIVGYL VTCEMAQGGGPATAFRVDGDSPESR LTVPGLSENVPYKFKVQARTTEGFG PEREGIITIESQDGGPFPQLGSRAG LFQHPLQSEYSSITTTHTSATEPFL VDGPTLGAQHLEAGGSLTRHVTQEF VSRTLTTSGTLSTHMDQQFFPTTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
