lef1
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  • Official Full Name
  • lymphoid enhancer-binding factor 1
  • Background
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • LEF1; lymphoid enhancer-binding factor 1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; TCF1-alpha; T cell-specific transcription factor 1-alpha;
Cat.#:LEF1-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1 protein, His-tagged
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Cat.#:LEF1-540HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1, His-tagged
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Cat.#:LEF1-9035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEF1 Protein
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Cat.#:LEF1-3373RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LEF1 Protein
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Cat.#:LEF1-6571CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LEF1
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Cat.#:LEF1-8995ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LEF1
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Cat.#:LEF1-4778HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEF1 293 Cell Lysate
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Involved Pathway

LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
MMP7; SIAH2L; TCF7L1A; RAC1A; CUL1B; FZD9; BTRC; PORCNL; LRP5; SERPINF1
Hippo signaling pathway
PRKCZ; AXIN1; BMP2; TCF7L2; WNT6; WNT7B; BMPR1A; WNT7A; MOBKL1A; FGF1
Adherens junction
LEF1; VCLA; CTNNA1; INSRA; RHOAB; RAC1A; TGFBR1; FER; SNAI1; CTNNA2
Melanogenesis
WNT3A; NRAS; CALML3; CREB1A; KRAS; FZD3A; CALML5; HRASB; WNT11; PRKCG
Pathways in cancer
CCNE2; F2RL3; TGFB1; CXCR4; LAMB1; KIT; NFKB1; TGFBR2; MDM2; FGF3
Colorectal cancer
MAPK9; RAC2; PIK3CD; AXIN2; MAPK3; CASP9; Casp3; MSH3; MAPK1; RHOA
Endometrial cancer
CDH1; FOXO3; AKT1; ARAF; PIK3CA; ILK; GRB2; RAF1; AXIN2; PIK3R1
Prostate cancer
MAP2K2; IGF1R; PIK3CA; NDRG1; CREB3L2; INS; SPINK1; ARID1A; CREB3L3; FGFR2
Thyroid cancer
LEF1; RXRA; TCF7; RET; CCND1; TRP53; TPM3; RXRB; CDH1; MAPK3
Basal cell carcinoma
FZD7; DVL2; HHIP; WNT9A; WNT5B; Shh; FZD9; FZD3; TCF7; SETD6
Acute myeloid leukemia
KIT; PIK3CB; MAPK3; AKT2; PIK3R3; MTOR; AKT3; SOS1; RPS6KB1; CCNA1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
CACNG7; DAG1; SGCA; ITGB1; ITGA1; TCF7L2; ITGA5; AASS; SGCD; DSP

Protein Function

LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein GATA1; TAF9; HMGA2; WT1; EBF1; THAP7; GATA2; LEF1; ZXDC; EHMT2
Function DNA binding
Related Protein CXXC1A; SIM1; IRX4A; MYO18A; ZNF652; SOX1; TRIM33; CAMTA1; REV3L; POLR1D
Function DNA binding, bending
Related Protein CRIP1; GATA1; TOP2A; TOP2B; HHEX; FOXD1; HMGB1; HMGA2; FOXD4; LEF1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein PGR; FUBP3; JUNBB; ZNF114; ZNF253; PDX1; CDX4; PRDM5; PRDM1; ETV6
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein SKINT8; ZFP39; GATA2; ZSCAN2; MEF2A; CDX1A; ZGLP1; PHF21A; CUX2; FOXF2
Function armadillo repeat domain binding
Related Protein CTNNBIP1; AXIN1; TCF7L2; STRN4; STRN; AXIN2; CNOT1; CHD8; LEF1; CALCOCO1
Function beta-catenin binding
Related Protein CD2AP; LEF1; FAM123B; NUMB; CTNNA3; HDAC6; CDH5; PTPRU; CDH1; ASH2L
Function chromatin binding
Related Protein ERG; EP300; CHAF1A; HOXD10; HMGB1; TAF2; ARID5A; POLR2B; MCM5; HOXC13
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein BIRC2; GAS6; TNFSF14; XIAP; AVP; NOL3; TNFAIP8; IGF1RA; MT3; RPS6KA1
Function enhancer binding
Related Protein SMAD3; ELL3; ARNT; MESP1; TIPARP; AHR; SP1; TCF12; SOX9; RAI1
Function estrogen receptor activity
Related Protein LEF1; ESR1; NKX3; NKX3-1; ESR2; ESR2B; GPR30; ESR2A
Function estrogen receptor binding
Related Protein CTNNB1; FUS; ISL1; FOXL2; NKX3-1; DYX1C1; PPID; NKX3; MMS19; NCOA1
Function gamma-catenin binding
Related Protein CTNNA1; APC2; CDH1; APC; LEF1; PTBP3; PTPRJ; FER; Fert2; DSG1A
Function histone binding
Related Protein PYGO2; ANP32E; H3F3B; Ctsl; COPRS; PRKCB; SMARCA2; NCL; RCC1; CD1d1
Function protein binding
Related Protein CD84; EIF3G; CPEB3; NOL3; PALLD; TNKS2; NCAM1A; CARKD; CHD7; MAP2K6
Function sequence-specific DNA binding
Related Protein NKX2-8; PPARGC1A; TA; ARX; HOXA3; FOXI1; FOXG1B; HSFY1; HOXD3; TFCP2
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein MEIS1; CIR1; HNF1B; PURA; SNAI2; GTF2IRD1; THRA; OLIG2; SOX9; NR1H4
Function transcription factor activity, sequence-specific DNA binding
Related Protein OTX1B; SS18L1; HOXB4; JUNBB; MYCLA; ZFP11; DMBX1; ZNF500; NKX2-6; ZNF192
Function transcription factor binding
Related Protein NFATC4; PBX2; MAPK1; MYC; AIP; GATA2; CEBPB; HMGA1; PSMD10; GATA6
Function transcription regulatory region DNA binding
Related Protein SP1; HNF1A; TFE3; JUN; GABPB1; TA; SALL1A; KLF2A; GATA5; RFX6
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein WT1; HOXA7; GATA1; BSX; TFAP2C; PLAG1; SOX4; GRHL1; PITX3; ZSCAN21
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein NKX2; REST; MSX1; FOXC1; OSR2; MSGN1; GATA2; STAG1; CSRNP3; MAFBB

Interacting Protein

LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.
CTNNB1; IGF1R; TLE1; 7242199; Hdac1; AURKA; BUB1; NRAS; RB1; MLH1; MSH2; BAX

LEF1 Related Articles

Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).