lef1
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  • Official Full Name
  • lymphoid enhancer-binding factor 1
  • Background
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • LEF1; lymphoid enhancer-binding factor 1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; TCF1-alpha; T cell-specific transcription factor 1-alpha;
Cat.#:LEF1-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1 protein, His-tagged
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Cat.#:LEF1-540HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1, His-tagged
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Cat.#:LEF1-9035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEF1 Protein
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Cat.#:LEF1-3373RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LEF1 Protein
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Cat.#:LEF1-6571CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LEF1
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Cat.#:LEF1-8995ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LEF1
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Cat.#:LEF1-4778HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEF1 293 Cell Lysate
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Involved Pathway

LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
CTBP2A; PORCN; BTRC; NFATC1; SERPINF1; SENP2; MAPK8A; BAMBIA; PPP3R2; AXIN2
Hippo signaling pathway
WNT3; WNT9B; FZD7; BMPR2; PRKCI; YWHAB; AFP; CRB1; ID1; YAP1
Adherens junction
PVRL4; ACTN3A; INSRB; CDH1; RAC3A; NLK1; RHOAA; PVRL1; MAP3K7; CSNK2A1
Melanogenesis
PRKACBA; PRKCB; TCF7L1A; PRKACAA; CAMK2D2; WNT8A; WNT2BB; GNAQ; GNAI2A; WNT10B
Pathways in cancer
PIK3R2; FZD10; LPAR3; LPAR6; EGLN2; HDAC2; ZBTB16; FGF20; TRAF4; CCNE2
Colorectal cancer
TP53; SMAD2; PIK3R2; MAPK9; TCF7; AKT1; CYCS; MAPK10; PIK3CD; CASP9
Endometrial cancer
CCND1; SOS1; AXIN1; NRAS; ARAF; PIK3R1; TCF7; LEF1; ERBB2; GRB2
Prostate cancer
INS1; TP53; MAP4K1; TGFA; PDGFC; FGFR2; CREB5; PDGFB; Ar; PDPK1
Thyroid cancer
TPR; CDH1; LEF1; RXRB; TRP53; TCF7; KRAS; CCDC6; TCF7L2; RXRA
Basal cell carcinoma
WNT8B; WNT16; APC; DVL2; FZD3; FZD6; WNT7B; AXIN2; PTCH2; Fzd4
Acute myeloid leukemia
TCF7L2; MTOR; AKT3; PPARD; MYC; KRAS; CEBPA; IKBKG; GRB2; AKT2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
CDH2; ITGB5; Itga10&Itgb1; CACNB1; ITGB4; ACTB; CACNG3; ATP2A2; PKP2; CACNB4

Protein Function

LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein U2AF2; EHMT2; LEF1; EHMT1; WT1; GATA1; TAF9; HMGA2; ZXDC; THAP7
Function DNA binding
Related Protein TAF6; MYSM1; ZNF454; PAX7A; NKX2.1; CALR; MAFBB; NKX2-5; ZNF582; ZNF76
Function DNA binding, bending
Related Protein HMGB3; SRY; FOXC1; GATA1; HHEX; HMGB2; TOP2A; TFAM; HMGB1; FOXD1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein E2F4; EBF2; EBF1; TCF4; JUNBB; CHD7; EN1; MAFA; RAX; PRDM1
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein MEF2D; LEF1; FOXC1; KAT2B; ESRRG; CDX1A; ATF2; GATA4; BHLHA15; ATF1
Function armadillo repeat domain binding
Related Protein STRN; CALCOCO1; CHD8; AXIN1; TCF7L2; CNOT1; AXIN2; STRN4; LEF1; CTNNBIP1
Function beta-catenin binding
Related Protein TCF7; ESR1; CDH1; TCF7L1A; RORA; CTNNA3; PROP1; FAM123B; LEF1; ASH2L
Function chromatin binding
Related Protein NFIA; SIN3A; TP53; ARID3A; SNAI2; DHX30; GATA1A; SKOR2; BEND6; ISL1
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein RPS6KA1; NAIP1; BIRC5; AVP; RPS6KA3; GAS6; TNFAIP8; BIRC3; CD27; SERPINB1A
Function enhancer binding
Related Protein AHR; SOX9; RAI1; ARNT; SP1; SMAD2; ELL3; LEF1; TCF12; SMAD3
Function estrogen receptor activity
Related Protein ESR2A; NKX3; GPR30; LEF1; ESR2; NKX3-1; ESR1; ESR2B
Function estrogen receptor binding
Related Protein WIPI1; DDX17; HSD17B10; ARRB1; TAF10; CCDC62; TMEM38A; CTNNB1; FOXL2; ISL1
Function gamma-catenin binding
Related Protein PTPRK; APC; CDH1; LEF1; FER; CTNNA1; PTPRJ; Fert2; TCF7L2; CDH2
Function histone binding
Related Protein USP16; HIST1H3G; L3MBTL2; NCAPD2; HIST1H4M; Ctsl; BRDT; DTX3L; RBBP4; MYSM1
Function protein binding
Related Protein ARFGAP1; GOLM1; PIANP; CEACAM6; CCT6A; NUP50; TAGLN2; BCL2L12; APOBEC2A; COPB1
Function sequence-specific DNA binding
Related Protein SIX4B; ERF; RORCA; INSM1A; HOXD3; EN2; FOXK2; ZNF397; DLX2A; NR1D4B
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein PTH; HNF4A; RFX3; ZFHX3; MEF2C; MEIS1; SOX9; HNF1B; BHLHE40; MYF6
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF518A; EGR2A; KLF4; MZF1; TCF19; NFIA; NFE2L2B; CEBPD; RXRGA; FOXD1
Function transcription factor binding
Related Protein NFATC4; MAFB; PARP1; NLK; Ar; CAMTA2; TRIM11; CEBPA; JUN; FOXA2
Function transcription regulatory region DNA binding
Related Protein FOXC2; ARID5B; H2AFY2; GATA6; RELA; GFI1; Arid4b; SMAD3; MTERFD1; NFKB1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein GLI2; RELA; GABPA; TFAP2A; MTF1; CREB1; BCL11B; FOXJ1; RFX4; TFAP2B
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ETV5; FOXF1; GATA2A; GATA2B; GATA2; CEBPA; DMRT1; TBX5; STAT3; SOHLH1

Interacting Protein

LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.
CTNNB1; IGF1R; TLE1; 7242199; Hdac1; AURKA; BUB1; NRAS; RB1; MLH1; MSH2; BAX

LEF1 Related Articles

Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).