LEF1

  • Official Full Name

    lymphoid enhancer-binding factor 1

  • Overview

    This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

  • Synonyms

    LEF1;lymphoid enhancer-binding factor 1;LEF-1;TCF10;TCF7L3;TCF1ALPHA;TCF1-alpha;T cell-specific transcription factor 1-alpha

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • Non
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
LEF1-540H Recombinant Human LEF1, His-tagged E.coli Human His 1-399aa
LEF1-166H Recombinant Human LEF1 protein, His-tagged E.coli Human His
LEF1-3373R Recombinant Rat LEF1 Protein Mammalian Cells Rat His
LEF1-6571C Recombinant Chicken LEF1 Mammalian Cells Chicken His
LEF1-8995Z Recombinant Zebrafish LEF1 Mammalian Cells Zebrafish His
LEF1-9035M Recombinant Mouse LEF1 Protein Mammalian Cells Mouse His
LEF1-4778HCL Recombinant Human LEF1 293 Cell Lysate HEK293 Human Non
LEF1-301549H Recombinant Human LEF1 protein, GST-tagged E.coli Human GST Met1-Asp98
LEF1-3029R Recombinant Rat LEF1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
LEF1-3029R-B Recombinant Rat LEF1 Protein Pre-coupled Magnetic Beads HEK293 Rat
LEF1-4817H Recombinant Human LEF1 Protein (Glu45-His260), N-His tagged E.coli Human His Glu45-His260
LEF1-5032M Recombinant Mouse LEF1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
LEF1-5032M-B Recombinant Mouse LEF1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
LEF1-7687H Recombinant Human LEF1 protein, His-tagged E. coli Human His

    Involved Pathway

    LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prostate Cancer PDGFA,BCL2,TP53,CCNE2,TCF7L2,SRD5A2,NFKB1,ATF4,NRAS,GSK3B
    Basal cell carcinoma GSK3B,TP53,GLI2,WNT7B,APC2,DVL3,AXIN1,FZD7,FZD2,WNT11
    Endometrial cancer PTEN,BRAF,CASP9,TCF7L2,CTNNA2,FOXO3,KRAS,PIK3CB,MLH1,TP53
    Adherens junction RHOA,TGFBR1A,ACTB1,ACTN4,PTPN6,RAC2,Fert2,PTPN1,CSNK2A2,WASL
    Thyroid cancer MAP2K2,TCF7,TPR,PPARG,MAP2K1,NTRK1,RET,TP53,RXRG,MAPK1
    Wnt signaling pathway CXXC4,PPARD,PRKACA,PRICKLE2B,CCND2A,FZD3A,LRP5,LRP6,FZD7,TBL1X
    Hippo signaling pathway CCND1,BMP6,PPP2R2B,ACTG1,WNT16,YWHAE,PPP2R2A,FGF1,PPP1CB,FBXW11
    Colorectal cancer TP53,BCL2,AXIN1,MSH2,SMAD3,CCND1,TCF7L2,SMAD4,BAD,PIK3R5
    Pathways in cancer TRAF4,TP53,FOXO1,GRB2,FGFR2,FGF6,RAF1,GNG8,FGFR1,NCOA4

    Protein Function

    LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding,DNA binding,DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.

    Function Related Protein
    gamma-catenin binding PTPRJ,PTBP3,APC2,CDH2,Fert2,TCF7L2,APC,CTNNA1,DSG1,DSG1A
    estrogen receptor activity ESR1,GPR30,ESR2,NKX3-1,NKX3,ESR2A,ESR2B
    DNA binding SPHK1,HIST3H2BB,ZNF512,DNAJC1,PDS5B,NKX3.3,TCEB3,KDM2B,AIFM2,ZFP827
    C2H2 zinc finger domain binding EHMT1,THAP7,GATA1,EHMT2,HMGA2,ZXDC,U2AF2,WT1,TAF9,GATA2
    armadillo repeat domain binding AXIN1,CNOT1,CTNNBIP1,CHD8,STRN4,CALCOCO1,STRN,AXIN2,TCF7L2
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process ARRB1,MT3,SERPINB9,VIL1,GAS6,XIAP,NAIP1,CD27,IGF1RB,SNCA
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MYF6,HIF1A,GATA2B,PPARG,STAT3,CTCF,ATF5,GABPA,MSGN1,PAX9
    estrogen receptor binding PPARGC1A,PPARG,DYX1C1,NCOA1,PHB2,CNOT1,WIPI1,NRIP1,PADI2,DDX5
    sequence-specific DNA binding FLI1B,SOX14,ATF4,MEOX1,TCF7L2,NKX2-3,BHLHE22,FOXG1A,ZNF396,SOX13

    Interacting Protein

    LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.

    CTNNB1;IGF1R;TLE1;7242199;Hdac1;AURKA;BUB1;NRAS;RB1;MLH1;MSH2;BAX

    Resources

    Research Area

    References

    • Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).
    • Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).

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