lef1
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  • Official Full Name
  • lymphoid enhancer-binding factor 1
  • Background
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • LEF1; lymphoid enhancer-binding factor 1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; TCF1-alpha; T cell-specific transcription factor 1-alpha;
Cat.#:LEF1-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1 protein, His-tagged
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Cat.#:LEF1-540HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1, His-tagged
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Cat.#:LEF1-9035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEF1 Protein
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Cat.#:LEF1-3373RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LEF1 Protein
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Cat.#:LEF1-6571CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LEF1
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Cat.#:LEF1-8995ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LEF1
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Cat.#:LEF1-4778HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEF1 293 Cell Lysate
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Involved Pathway

LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
LRP5; NFATC3; PPARD; EP300; PLCB3; PORCN; DAAM1B; SFRP4; NLK1; VANGL2
Hippo signaling pathway
TCF7L2; APC2; WNT5B; FZD3; PPP1CC; WNT2; DLG1; WNT1; BMPR2; MPP5
Adherens junction
RHOAB; FYNA; CDC42; CTNND1; VCL; FGFR1A; PTPN6; WASF3B; PVRL2; SMAD3
Melanogenesis
CALML3; DVL1B; PRKACBA; CALM3A; CAMK2G; GNAI3; a; MITF; NRAS; FZD7
Pathways in cancer
HSP90AA1; FOS; NFKBIA; PDGFRB; EGLN1; BDKRB1; PDGFRA; CBLB; FZD1; BCL2L1
Colorectal cancer
DCC; AKT1; FOS; MAPK9; RAC3; APPL1; PIK3CA; RALGDS; KRAS; TRP53
Endometrial cancer
ILK; AKT1; TP53; APC2; BRAF; PTEN; CTNNA3; CDH1; LEF1; PIK3CA
Prostate cancer
PIK3CB; TCF7L2; BAD; AKT1; MAPK3; CREB3L3; ACTL6B; PIK3R2; HSP90B1; CREB3L2
Thyroid cancer
TPM3; MAPK3; KRAS; MAP2K1; TPR; BRAF; NRAS; MAPK1; PAX8; HRAS
Basal cell carcinoma
SMO; SUFU; FZD8; WNT4; TCF7; GLI1; WNT7B; TCF7L2; TRP53; WNT3
Acute myeloid leukemia
BRAF; PIK3CB; CHUK; TCF7; AKT3; STAT5A; IKBKB; MAP2K2; LEF1; HRAS
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
LAMA2; ITGA3; DSP; CACNA2D3; CACNG6; CACNG4; TCF7L2; GJA1; ITGB3; ITGA4

Protein Function

LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein EBF1; EHMT2; WT1; HMGA2; GATA2; EHMT1; THAP7; GATA1; ZXDC; LEF1
Function DNA binding
Related Protein SP8B; PHC2A; IRF2A; ZNF529; PDCD2; SPI1A; SIX2B; PIN4; ZNF71; ZFY2
Function DNA binding, bending
Related Protein HMGA2; HMGB3; HMGB2; TFAM; FOXL1; CRIP1; SRY; FOXC1; TERF1; HMGB1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein DLX4; TCF3B; FOXI1; PBX1; MEOX2; NFAT5; FLI1; ZNF92; ZNF331; GZF1
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein RFX6; ZFY2; TFAP2E; PRDM12B; IKZF3; MEF2D; STOX1; CREB3L3; NFKB1; GATA2B
Function armadillo repeat domain binding
Related Protein AXIN1; CALCOCO1; TCF7L2; CHD8; CTNNBIP1; LEF1; AXIN2; CNOT1; STRN4; STRN
Function beta-catenin binding
Related Protein APC2; ESR1; CTNNA1; PTBP3; LEF1; SLC9A3R2; SOX9; PTPRU; DACT1; CDH2
Function chromatin binding
Related Protein Trl; PHF8; SMARCA2; WDHD1; FLI1; RING1; HDAC7A; PPARG; MAZ; CREB3L1
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein SERPINB1A; RPS6KA3; BIRC8; SERPINB9; NOL3; MT3; XIAP; C1QL4L; IGF1RA; BIRC3
Function enhancer binding
Related Protein ARNT; MESP1; TIPARP; LEF1; AHR; SMAD3; TCF12; SOX9; SMAD2; TCF3
Function estrogen receptor activity
Related Protein NKX3; LEF1; ESR2B; ESR1; ESR2; ESR2A; GPR30; NKX3-1
Function estrogen receptor binding
Related Protein LEF1; FOXL2; ARRB1; CNOT1; TAF10; NKX3; PPARGC1A; PPARG; NSD1; STRN
Function gamma-catenin binding
Related Protein APC; PTPRK; APC2; DSG1A; LEF1; CDH2; PTPRJ; Fert2; CDH1; CTNNA1
Function histone binding
Related Protein USP16; NFKBIL2; SART3; RCC1; TBL1XR1; SERPINB1A; PRKCBP1L; HIST1H4I; PRKCB; SET
Function protein binding
Related Protein HINT2; RTN4A; TAF13; SNAP25; PVRL1; CHORDC1; FOXG1; DNAJC11; ACO1; TACR1
Function sequence-specific DNA binding
Related Protein HOXB10A; FOXO1B; CREBZF; RERE; SOX30; KLF5; POU1F1; Ar; CHES1; NKX6.2
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein MYOG; MYOD1; MYF6; RELA; ATF2; T; NR1H4; FOXP3; SOX7; HIF1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXO4; NME2; GATA2A; TP73; DMRT3A; POU5F3; SOX21; SPI1; POU3F3A; FOXN3
Function transcription factor binding
Related Protein DRG1; SNF8; TFDP1; PURA; TNFRSF10A; PIAS2; SOST; ZBTB49; RELA; THRA
Function transcription regulatory region DNA binding
Related Protein DLX5; OVOL2; SOX5; SMAD6; TBX16; ASH2L; KLF11; TBX21; TFAP4; ATF6B
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SREBF1; SMAD1; CREB3L1; TFAM; NKX2; CEBPG; Ar; ONECUT1; NR2E1; DBP
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein MYOCD; GATA3; CSRNP2; BARHL1B; GATA2; PLAGL1; FEZF2; ALX4; MAFGA; SOHLH1

Interacting Protein

LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.
CTNNB1; IGF1R; TLE1; 7242199; Hdac1; AURKA; BUB1; NRAS; RB1; MLH1; MSH2; BAX

LEF1 Related Articles

Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).