lef1
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  • Official Full Name
  • lymphoid enhancer-binding factor 1
  • Background
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • LEF1; lymphoid enhancer-binding factor 1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; TCF1-alpha; T cell-specific transcription factor 1-alpha;
Cat.#:LEF1-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1 protein, His-tagged
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Cat.#:LEF1-540HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1, His-tagged
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Cat.#:LEF1-9035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEF1 Protein
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Cat.#:LEF1-3373RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LEF1 Protein
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Cat.#:LEF1-6571CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LEF1
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Cat.#:LEF1-8995ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LEF1
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Cat.#:LEF1-4778HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEF1 293 Cell Lysate
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Involved Pathway

LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
SENP2; RHOAB; FZD6; TCF7L2; FZD9B; CSNK1A1L; PPARDB; FBXW2; RBX1; LEF1
Hippo signaling pathway
GLI2; WNT10B; SMAD7; Fzd4; PPP2CA; BMPR2; YAP1; PPP2R2B; FZD6; PPP2R1A
Adherens junction
FYNB; TGFBR1; WASL; WASF1; NLK1; CTNNB1; IGF1R; PTPN1; CTNNA2; BAIAP2A
Melanogenesis
PRKACB; WNT8B; KITLG; a; KITLGA; CALML3; FZD2; FZD3B; DCT; TCF7
Pathways in cancer
PTGER2; PIK3CA; GSTP1; TPM3; FGF6; GNG12; WNT7A; LAMC1; SMAD3; IGF1
Colorectal cancer
MAPK3; MSH3; PIK3R3; SMAD3; RALGDS; PIK3CG; KRAS; TCF7; RAC1; SMAD4
Endometrial cancer
ERBB2; ARAF; CASP9; AKT2; TCF7L2; PIK3CB; PIK3R2; APC2; PIK3CD; NRAS
Prostate cancer
GSTP1; CREB3L1; ARID1A; CCND1; PIK3CG; PDGFRB; Ar; SMARCD1; ACTL6B; PIK3R5
Thyroid cancer
TCF7L2; PAX8; LEF1; MAPK3; NTRK1; MAPK1; CDH1; TP53; TCF7; TPR
Basal cell carcinoma
FZD1; WNT3; WNT4; WNT7A; FZD2; WNT2B; APC; WNT7B; FZD3; WNT5B
Acute myeloid leukemia
PIK3R5; RUNX1; STAT5B; EIF4EBP1; KIT; SFPI1; FLT3; LEF1; PIK3R3; NRAS
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
EMD; ACTN2; ITGB4; GJA1; TCF7; ACTN4; ITGA3; CACNA2D3; DES; CTNNA2

Protein Function

LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein THAP7; U2AF2; GATA1; WT1; HMGA2; EHMT1; EHMT2; EBF1; ZXDC; GATA2
Function DNA binding
Related Protein ZFP41; ZNF471; ZHX1; ZBTB17; SP6; TRIM26; ERCC2; HIST2H2AA4; POLR2J; SCMH1
Function DNA binding, bending
Related Protein FOXD4; HMGA2; FOXI1; GATA1; HMGB1; CRIP1; TOP2B; LEF1; TOP2A; TERF1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ASCL1; MED8; TCF7L2; FOSL1; GZF1; TBX3; FIGLA; TFAM; PPARA; NKX3-2
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein DMBX1; FOXF1; ZNF256; ZNF548; ZFP39; ZNF773; NR1I2; IKZF5; LEF1; ZIK1
Function armadillo repeat domain binding
Related Protein LEF1; STRN; CALCOCO1; CNOT1; AXIN1; STRN4; AXIN2; TCF7L2; CTNNBIP1; CHD8
Function beta-catenin binding
Related Protein CDH1; PXN; SHROOM2; CARM1; PTBP3; CD2AP; ESR1; CXADR; PROP1; PTPRU
Function chromatin binding
Related Protein MORF4L1; JARID2; PBRM1; KIAA0101; POLG; SLC30A9; HINFP; JDP2; KAT2B; POU1F1
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein PRDX5; BIRC8; TNFSF14; IGF1RA; BIRC3; C1QL4L; AVP; BIRC5; BIRC7; IGF1RB
Function enhancer binding
Related Protein SMAD3; FOXH1; LEF1; SOX9; ARNT; SMAD2; SP1; TIPARP; ELL3; TCF3
Function estrogen receptor activity
Related Protein ESR2; LEF1; NKX3-1; ESR2B; ESR2A; ESR1; NKX3; GPR30
Function estrogen receptor binding
Related Protein XBP1; FOXL2; ISL1; CTNNB1; LEF1; NKX3; TAF10; HSD17B10; PPID; NSD1
Function gamma-catenin binding
Related Protein PTPRK; Fert2; FER; TCF7L2; PTPRJ; LEF1; APC; CDH1; PTBP3; CTNNA1
Function histone binding
Related Protein USP16; JAK2; TBL1XR1; PHF21A; ZMYND11; CD1D; UIMC1; USP3; HIST1H3C; HIST1H3E
Function protein binding
Related Protein MYPOP; ADIPOQ; TAE1; ARAF; TRPV4; SRRT; TTLL6; ZNF133; SAMHD1; TINAGL1
Function sequence-specific DNA binding
Related Protein NR1H4; MSXB; MYOG; HOXD12; NR2F6; HOXA11A; LHX1B; DMBX1; TFCP2; RORAA
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein POU3F1; GTF2IRD1; ATF2; PURA; LEF1; NKX2-5; TEAD2; MEF2C; ZFHX3; SPI1
Function transcription factor activity, sequence-specific DNA binding
Related Protein CBL; FOSL1A; ELK4; NKX6-2; TFAP2B; HOMEZ; FOXD4; ZNF668; NANOG; RXRB
Function transcription factor binding
Related Protein GNPTAB; GTF2A2; KDM1A; SIRT1; TFDP1B; SOST; KAT6B; GTF2F1; PBX2; EPN1
Function transcription regulatory region DNA binding
Related Protein BCOR; SOX17; ATF4; NKX2; ZFP335; GATA4; NKX3; RBBP5; SALL1A; NR1D1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HOXA10; PAX8; ZNF750; NFAT5; PITX3; PLAG1; OTX2; NR6A1; MIXL1; MYBL2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein BARHL1B; SLAMF7; CSRNP3; AIRE; BHLHA15; OSR2; STAG1; MYOD1; ONECUT3; BARX2

Interacting Protein

LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.
CTNNB1; IGF1R; TLE1; 7242199; Hdac1; AURKA; BUB1; NRAS; RB1; MLH1; MSH2; BAX

LEF1 Related Articles

Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).