lef1
Share
  • Official Full Name
  • lymphoid enhancer-binding factor 1
  • Background
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • LEF1; lymphoid enhancer-binding factor 1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; TCF1-alpha; T cell-specific transcription factor 1-alpha;
Cat.#:LEF1-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1 protein, His-tagged
+Inquiry
Cat.#:LEF1-540HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1, His-tagged
+Inquiry
Cat.#:LEF1-9035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEF1 Protein
+Inquiry
Cat.#:LEF1-3373RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LEF1 Protein
+Inquiry
Cat.#:LEF1-6571CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LEF1
+Inquiry
Cat.#:LEF1-8995ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LEF1
+Inquiry
Cat.#:LEF1-4778HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEF1 293 Cell Lysate
+Inquiry

Involved Pathway

LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
FZD7A; SOX17; NLK; LRP6; PLCB3; CHD8; RAC3B; AXIN2; TCF7L1A; RHOAA
Hippo signaling pathway
FZD5; FGF1; SNAI2; BMPR1A; GDF6; BBC3; YWHAH; PPP1CA; CCND1; LEF1
Adherens junction
SMAD3A; INSRA; FARP2; RAC3B; PTPRFB; VCLA; SNAI1; RHOA; ACTB1; MAPK3
Melanogenesis
PRKCBA; RAF1A; WNT2; MAP2K2A; MITF; MITFA; HRAS; FZD8A; PRKCA; MAPK3
Pathways in cancer
Fgf15; SFPI1; ITGB1; RASSF5; MET; ROCK2; RALGDS; ROCK1; RUNX1; SKP2
Colorectal cancer
MSH3; LEF1; TP53; RHOA; BCL2; SMAD2; PIK3R5; TCF7L2; RALGDS; AXIN2
Endometrial cancer
ELK1; PIK3CD; MAPK1; PIK3R2; AKT2; CTNNA3; TCF7; PIK3CB; AXIN1; TRP53
Prostate cancer
ACTL6B; INS; CCND1; SOS1; TRP53; SRD5A2; RELA; NDRG1; Pdgfa&Pdgfb; SPINK1
Thyroid cancer
TFG; CCDC6; NTRK1; PPARG; RXRG; HRAS; TCF7; TP53; CCND1; BRAF
Basal cell carcinoma
APC2; GLI1; WNT3A; WNT7B; FZD5; AXIN1; WNT7A; WNT9B; BMP2; WNT9A
Acute myeloid leukemia
CCNA1; STAT5A; TCF7L2; LEF1; AKT1; KIT; FLT3; PML; MAP2K1; NRAS
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
CTNNA1; CACNA2D1; CDH2; ITGB8; ITGB1; DSG2; ITGA1; JUP; GJA1; CACNG3

Protein Function

LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein EHMT1; GATA1; EHMT2; U2AF2; LEF1; GATA2; EBF1; TAF9; HMGA2; ZXDC
Function DNA binding
Related Protein EVE1; IRX7; H2AFVA; PURBA; LHX1A; HMX4; TADA2A; ZFP322A; SUPV3L1; JUNBA
Function DNA binding, bending
Related Protein TOP2B; SRY; FOXL1; HMGB1; GATA1; HMGA2; FOXC1; TERF1; HMGB3; HHEX
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZNF331; MAX; GMEB1; PAX5; MYF5; SIX4; NOBOX; PAX8; YBX1; HSF1
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein NR1I2; ALX4; NKX2-1; SATB1; RARG; ATF4B2; TAL2; PHF21B; ZFP583; ALX1
Function armadillo repeat domain binding
Related Protein STRN; AXIN2; CTNNBIP1; CALCOCO1; AXIN1; TCF7L2; CNOT1; STRN4; CHD8; LEF1
Function beta-catenin binding
Related Protein PXN; PTPRK; TRPC4; SLC9A3R2; KDM6B; CDH2; GLI3; SOX9; TCF7L1B; CDH1
Function chromatin binding
Related Protein TWIST2; KLF14; SNAI2; TOX3; CREB3L1; TDRD3; TFAP2A; MITF; PDX1; SAFB
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein CD27; BIRC7; RPS6KA1; XIAP; AVP; IGF1RB; GAS6; MT3; BIRC5; PRDX5
Function enhancer binding
Related Protein TCF3; MESP1; SOX9; ELL3; AHR; RAI1; TIPARP; TCF12; LEF1; ARNT
Function estrogen receptor activity
Related Protein ESR2B; NKX3-1; NKX3; ESR2; ESR1; GPR30; LEF1; ESR2A
Function estrogen receptor binding
Related Protein TMEM38A; LEF1; NKX3; PHB2; WIPI1; XBP1; NSD1; HSD17B10; NRIP1; ISL1
Function gamma-catenin binding
Related Protein TCF7L2; Fert2; DSG1; APC2; APC; CTNNA1; CDH1; PTBP3; CDH2; PTPRJ
Function histone binding
Related Protein HIST2H4; H3F3A; SUPT6H; ANP32E; SFMBT1; HIST1H4I; HIST1H3D; DNAJC2; HIST1H4K; SART3
Function protein binding
Related Protein RPGRIP1; SNRPD2; EGLN1; NUMB; MED17; WDR34; DUSP21; ELMO3; PPP2R1A; COPB1
Function sequence-specific DNA binding
Related Protein HOXD11; TLX3B; HOXC10A; HSFX1; DBX2; ZNF498; ESRRGB; FOXQ1B; SPI1B; ZBTB33
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein FOXF1; CIR1; PROX1; GLI1; OLIG2; LEF1; MEF2C; SRY; GTF2IRD1; SOX7
Function transcription factor activity, sequence-specific DNA binding
Related Protein RERE; ETS2; TULP4; ZRANB2; HNF1BA; NR2F6; TRPS1; CSRNP3; MNT; PDX1
Function transcription factor binding
Related Protein GCM1; RNF222; DRG1; TCF7L2; BCOR; ESR1; STK36; UBN1; POU1F1; TP53
Function transcription regulatory region DNA binding
Related Protein CDK9; ZFP382; CDK5RAP2; GABPB2; BRD7; POU5F1; SP1; NKX2; NR1D1; GATA3
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MZF1; ESR1; STAT3; ATF2; TFE3; MYBL1; TRP63; EBF2; FOXA1; MESP1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein LMO2; NEUROD2; ATF2; REST; GATA5; CSRNP1; BARX2; GATA2B; BARX1; RAD21

Interacting Protein

LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.
CTNNB1; IGF1R; TLE1; 7242199; Hdac1; AURKA; BUB1; NRAS; RB1; MLH1; MSH2; BAX

LEF1 Related Articles

Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).