LEF1

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LEF1

Official Full Name lymphoid enhancer-binding factor 1
Background This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Synonyms LEF1; lymphoid enhancer-binding factor 1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; TCF1-alpha; T cell-specific transcription factor 1-alpha;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LEF1-166H Recombinant Human LEF1 protein, His-tagged E.coli His
    Human LEF1-4778HCL Recombinant Human LEF1 293 Cell Lysate HEK293 N/A
    Human LEF1-540H Recombinant Human LEF1, His-tagged E.coli His
    Mouse LEF1-9035M Recombinant Mouse LEF1 Protein Mammalian Cell His
    Rat LEF1-3373R Recombinant Rat LEF1 Protein Mammalian Cell His
    Chicken LEF1-6571C Recombinant Chicken LEF1 Mammalian Cell His
    Zebrafish LEF1-8995Z Recombinant Zebrafish LEF1 Mammalian Cell His

    LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway PPP3R1; CSNK1A1L; WNT3; FZD6; PRKACAA; WNT2BA; CCND1; LEF1; WNT1; SFRP1
    Hippo signaling pathway PRKCI; PPP1CB; SMAD4; SMAD1; CTGF; FZD8; BBC3; ACTB; FGF1; AMH
    Adherens junction PTPN6; SMAD3A; SSX2IP; LMO7A; PVRL1B; ACTN2B; ACTN2; PTPRJA; WASB; CDH1
    Melanogenesis CALM3B; PRKACA; MAPK3; GNAS; FZD2; MAPK1; POMC; CALM; CALM2; MAP2K2
    Pathways in cancer WNT2B; WNT11; PLD1; IL-8; Fzd4; TCF7; RALGDS; GNB1; FZD10; BRCA2
    Colorectal cancer APC; PIK3R2; BIRC5; RAC1; PIK3CD; KRAS; Casp3; MAPK10; FOS; PIK3CA
    Endometrial cancer MAP2K1; PIK3CD; PIK3R3; BRAF; TCF7L2; PIK3CA; GSK3B; AXIN1; NRAS; AKT2
    Prostate cancer ACTL6B; Pdgfa&Pdgfb; PDGFD; NDRG1; SRD5A2; ERBB2; NRAS; INS; PDGFB; ATF4
    Thyroid cancer NRAS; RXRA; PPARG; NTRK1; TPM3; RXRG; TCF7; TRP53; CDH1; CCDC6
    Basal cell carcinoma FZD5; DVL1; PTCH1; FZD1; Fzd4; WNT6; FZD8; WNT7B; WNT8A; LEF1
    Acute myeloid leukemia SFPI1; TCF7L2; MAPK1; TCF7; IKBKB; STAT5A; ARAF; AKT1; PML; MTOR
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGB4; CACNG1; ITGA5; SGCB; SGCA; ITGAV; ITGA4; ITGB8; ITGB7; CACNA2D2

    LEF1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.

    Function Related Protein
    C2H2 zinc finger domain binding WT1; ZXDC; LEF1; GATA1; EHMT2; EHMT1; GATA2; U2AF2; EBF1; THAP7
    DNA binding SIX6B; FOXG1D; SUPT3H; PARP1; TEAD4; TBL1Y; POLA2; ZNF703; MCMDC2; EGR4
    DNA binding, bending HMGB2; SRY; FOXI1; GATA1; TFAM; FOXL1; HMGA2; FOXC1; LEF1; HMGB1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GLI3; NKX2-8; TGIF1; SKIL; NFATC4; PGR; FEZF2; PBX1; RBPJA; ZNF264
    RNA polymerase II regulatory region sequence-specific DNA binding ZFY1; HES6; H2AFY2; NHLH2; ALX1; EAF2; ZNF583; OSR2; LYL1; HMX1
    armadillo repeat domain binding STRN; LEF1; AXIN1; CTNNBIP1; STRN4; AXIN2; CNOT1; CHD8; TCF7L2; CALCOCO1
    beta-catenin binding SLC9A3R1; PTPRK; NF2; GRIP1; CTNNA1; CD2AP; GSK3B; AXIN2; MED12L; SALL1
    chromatin binding FOXN4; SIRT7; NCOA1; CEBPB; HIF1AB; DNMT3A; ING2; CENPB; TOX2; BARX2
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process SERPINB1A; CD27; TFAP2B; MT3; TNFAIP8; BIRC5; BIRC7; DPEP1; PRDX3; IGF1RB
    enhancer binding LEF1; ARNT; SOX9; TCF3; SMAD3; AHR; TIPARP; TCF12; SP1; SMAD2
    estrogen receptor activity NKX3; ESR2; GPR30; ESR2A; ESR1; ESR2B; NKX3-1; LEF1
    estrogen receptor binding NKX3-1; ISL1; PHB2; NKX3; PCNA; CCDC62; CTNNB1; TAF10; ARRB1; TMEM38A
    gamma-catenin binding APC2; CDH1; CTNNA1; DSG1; LEF1; PTBP3; PTPRJ; FER; Fert2; CDH2
    histone binding CD1d1; UHRF1; HIST1H4D; NAP1L2; H3F3A; BRDT; PRMT7; CD1D; ELP2; MCM2
    protein binding CDC42EP2; LRP2; EFHC2; IER3; MKNK2; ZMYND10; UXT; TRIM22; SCG5; UBQLN4
    sequence-specific DNA binding SOX6; ZBTB14; TAF1; NKX2-1; FOXP4; CDX1B; MXTX2; VDRB; PPARGC1A; GLI1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IRF8; TFAP4; POU4F1; HNF1B; THRA; SRF; FOXC1; RFX3; TEAD2; NR5A1
    transcription factor activity, sequence-specific DNA binding E2F3; ATF7; PHF5A; PDX1; TBX5A; SP140; ZNF691; HIF1AL; DMRTA2; CNBP
    transcription factor binding UBE2I; RNF4; SMAD3; SOX17; ENPP2; NFYC; MED6; NR0B1; NFKBIA; CREG1
    transcription regulatory region DNA binding MEF2C; CEBPA; JUN; SOX2; SERPINB1A; LEF1; DDIT3; GATA6; ZFP821; RCOR1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PBX1; POU3F2; EBF3A; MITFB; NR2E1; MYBL2; POU4F1; HMGA2; FIGLA; JUNB
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding SOHLH1; FOXF1; STAT3; BARX2; GATA6; HOXD8; NR1I3; MAF; MSGN1; NEUROD2

    LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.

    CTNNB1; IGF1R; TLE1; 7242199; Hdac1; AURKA; BUB1; NRAS; RB1; MLH1; MSH2; BAX

    Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
    Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).

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