MED1 Protein, mediator complex subunit 1


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Official Full Name mediator complex subunit 1
Background The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Synonyms MED1; mediator complex subunit 1; PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220; mediator of RNA polymerase II transcription subunit 1; ARC205; TRIP-2; PPAR binding protein; PPAR-binding protein; PPARG binding protein; TR-interacting protein 2; p53 regulatory protein RB18A; thyroid receptor interacting protein 2; thyroid receptor-interacting protein 2; vitamin D receptor-interacting protein 230 kD; activator-recruited cofactor 205 kDa component; peroxisome proliferator-activated receptor-binding protein; vitamin D receptor-interacting protein complex component DRIP205; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED1-436H Recombinant Human MED1 Protein, His-tagged E.coli His
    Human MED1-800H Recombinant Human MED1, GST-tagged E.coli GST
    Mouse MED1-9679M Recombinant Mouse MED1 Protein Mammalian Cell His

    MED1 involved in several pathways and played different roles in them. We selected most pathways MED1 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway HDAC3; CASP9; RXRG; MED12L; RCAN1; PLN; SLC16A2; ATP1A4; KAT2B; NCOR1

    MED1 has several biochemical functions, for example, LBD domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED1 itself. We selected most functions MED1 had, and list some proteins which have the same functions with MED1. You can find most of the proteins on our site.

    Function Related Protein
    LBD domain binding MED1; CITED2; PROX1; CITED1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZBTB7A; ELF1; HSF1; MYF6; BSX; ZNF114; NEUROG3; MAX; TBP; TFE3
    RNA polymerase II transcription cofactor activity MED22; CRSP7; TP53BP1; MED11; MED15; MED8; MED7; MED17; MED4; MED13L
    RNA polymerase II transcription factor activity, sequence-specific DNA binding NPAS4A; FOXD4L1; SOX21; PLAGL1; TP53; TP73; ATF4B2; FOXH1; SPI1; SOX8
    chromatin DNA binding FOXC2; BCL6; RELA; PER1; NEUROG3; NOTCH1; H1F0; THRA; HIST1H1C; EZH2
    chromatin binding MB21D2; SSRP1A; EWSR1A; HESX1; REL; FABP1; ARX; EOMES; CBFA2T3; SP3
    core promoter binding RELB; MYOG; NEUROG3; NOTCH1; MED1; SPI1; MYBBP1A; PYDC3; HMGA2; NKX3
    estrogen receptor binding PPID; FOXL2; NKX3-1; ISL1; PCNA; ARRB1; DDX5; PPARGC1A; MED1; HSD17B10
    ligand-dependent nuclear receptor binding NCOA3; NR1H4; ISL1; TRIM24; MED1; NCOR2; UBA3; SMARCE1; NCOA2; TRIP4
    ligand-dependent nuclear receptor transcription coactivator activity MED24; BUD31; THRAP3; MED4; TADA3; MED17; PRKCBB; ENY2; AASS; ATXN7L3
    mediator complex binding NIPBL; MED1; SMC3; SMC1A
    nuclear hormone receptor binding NRIP1; TACC2; ACTN4; SIRT1; TCF7L2; SMARCD3; NCOA3; NCOR1; CRX; HIF1A
    peroxisome proliferator activated receptor binding MED1; PPARGC1A; NR0B2; PRMT2; NFATC4; ASXL2; IKBKG; HMGA1; CREBBP; EP300
    protein binding ASH2L; SNX27; SIVA1; HIST1H4J; IPO11; CLCNKB; SPANXC; BBS5; MSX2; ZKSCAN17
    receptor activity TNFRSF25; GRIN2BB; ABP1; VMN1R47; GFRA1A; CSF3R; ROBO4; ADIPOR2; CNTNAP1; CMKLR1
    retinoic acid receptor binding RXRA; MED25; HMGA1; AASS; PRAMEF1; PRMT2; PRAMEF2; ACTN4; PRAMEF6; NSD1
    thyroid hormone receptor binding TAF7; NCOR1; MED16; MED12; MED13; TRIP12; NR0B2; FUS; ZNHIT3; THRAP3
    thyroid hormone receptor coactivator activity ACTN2; MED1; MED16; NCOA2
    transcription coactivator activity SAP130; PPARGC1A; POU2AF1; FUS; MMS19; ESRRB; MED6; SCAND1; CCAR1; MLL5
    transcription cofactor activity ZNF671; ZFP710; RFXANK; BTG1; PIR; NMI; WDR75; CREB1; LDB2; SND1
    transcription factor binding NR0B2A; YWHAZ; ARID5A; NCOR2; ENPP2; SNF8; NAB1; SOX10; JUNB; SOX17
    ubiquitin protein ligase activity MGRN1; ANAPC11; UBE2G2; RFWD2; HUWE1; LTN1; BTRC; WWP2; LRSAM1; UBE2G1A
    vitamin D receptor binding TAF7; RXRA; THRAP3; MED4; MED24; MED1; MED16; MED30; TAF11; MED17

    MED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED1.

    MED10; CDK8; MED19; THRA

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