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MED1

  • Official Full Name

    mediator complex subunit 1

  • Overview

    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
  • Synonyms

    MED1; mediator complex subunit 1; PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220; mediator of RNA polymerase II transcription subunit 1; ARC205; TRIP-2; PPAR binding protein; PPAR-binding protein; PPARG binding protein; TR-interacting protein 2; p53 regulatory protein RB18A; thyroid receptor interacting protein 2; thyroid receptor-interacting protein 2; vitamin D receptor-interacting protein 230 kD; activator-recruited cofactor 205 kDa component; peroxisome proliferator-activated receptor-binding protein; vitamin D receptor-interacting protein complex component DRIP205; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MED1-800H Recombinant Human MED1, GST-tagged E.coli GST 207-556aa
Human MED1-01H Recombiant Human MED1 Protein Lysate HEK293T
Human MED1-436H Recombinant Human MED1 Protein, His-tagged E.coli His Met1~Thr212
Human MED1-4421H Recombinant Human MED1 protein, His-SUMO-tagged E.coli His-SUMO 878-1031aa
Mouse MED1-9679M Recombinant Mouse MED1 Protein Mammalian Cell His
Mouse MED1-5440M-B Recombinant Mouse MED1 Protein Pre-coupled Magnetic Beads HEK293
Mouse MED1-5440M Recombinant Mouse MED1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MED1 Related Research Area

MED1 involved in several pathways and played different roles in them. We selected most pathways MED1 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Thyroid hormone signaling pathwayATP1B3;SLC9A1;RXRG;RXRA;ATP1A1;PFKFB2;PDPK1;MED12;PIK3R2

MED1 has several biochemical functions, for example, LBD domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED1 itself. We selected most functions MED1 had, and list some proteins which have the same functions with MED1. You can find most of the proteins on our site.

Function Related Protein
LBD domain bindingMED1;PROX1;CITED2;CITED1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingKLF17;NFE2L3;MXD1;CDX4;NR2C1;RFX2;ELF3;ZNF100;FEZF2
RNA polymerase II transcription cofactor activityMED21;MED15;MED8;MDT-19;MED7;FOXH1;MED20;PPRC1;MED30
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFOXD5;ZNF446;TRP53;ETV6;ELF2A;ZNF174;FOXJ1A;FOXA3;TWIST1
chromatin DNA bindingHIST1H1E;EZH2;HDAC3;APEX1;CLOCK;MYOD1;NEUROG3;GRHL3;INSM1A
chromatin bindingJDP2;GATA3;SUPT5H;KDM8;CRX;POU1F1;HDAC7;ARNTL1B;SIN3B
core promoter bindingHNRNPU;GATA1;IFI203;AGO2;MED1;HDAC6;EZH2;E2F8;TFAP2C
estrogen receptor bindingPCNA;LEF1;DYX1C1;PADI2;DDX5;TAF10;ARRB1;NRIP1;MMS19
ligand-dependent nuclear receptor bindingNCOA2;ISL1;NCOA3;TRIM24;NCOR2;BAZ2A;SMARCE1;MED1;TRIP4
ligand-dependent nuclear receptor transcription coactivator activityPSMC3IP;NCOA1;SMARCD3;NCOA2;TADA3;PUS1;BUD31;PPARGC1A;KDM1A
mediator complex bindingSMC3;MED1;NIPBL;SMC1A
nuclear hormone receptor bindingSMARCD3;SNW1;NRIP1;TCF7L2;NCOR1;MED1;MYOD1;CRX;EP300
peroxisome proliferator activated receptor bindingASXL1;PPARGC1A;PRMT2;NFATC4;MED1;HMGA1;CREBBP;ASXL2;EP300
protein bindingRNF180;CYP4F2;C3orf62;FAM124B;COX8A;CLIP1;C15orf57;TM4SF4;FAM71C
receptor activityRAMP1;FAS;MED24;CADM4;GABRA5;LILRA3;TLR1;GRIN1B;ITGB1B.2
retinoic acid receptor bindingRXRA;MED25;PRAMEF1;HMGA1-RS1;SNW1;ASXL1;PRAMEF10;HMGA1;CTBP2
thyroid hormone receptor bindingMED24;MED17;NSD1;THRAP3;NR0B2;TAF7;TRIP12;ZNHIT3;HMGN3
thyroid hormone receptor coactivator activityMED16;ACTN2;MED1;NCOA2
transcription coactivator activityMKL1B;MTA1;LPIN1;CITED4;WWC1;MED26;RNF20;PCBD1;GABPA
transcription cofactor activityPOU2AF1;MED30;ANKRA2;RFXANK;MSX2;ZNF710A;NSD1;LDB2B;ZNF763
transcription factor bindingPPRC1;PRICKLE1;TRIB1;TAF12;PELP1;HES6;TAF7;RNF222;NKX2-5
ubiquitin protein ligase activityHLTF;ANKIB1;MDM2;MARCH1;RNF14;HERC6;DZIP3;UBE2S;UBE2G1B
vitamin D receptor bindingMED14;MED1;TAF11;MED24;RXRA;MED16;SNW1;MED30;TAF7

MED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED1.

MED10; CDK8; MED19; THRA

  • Q&As
  • Reviews

Q&As (5)

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Are there specific cancer types where MED1 protein is particularly relevant in clinical diagnostics? 11/24/2021

MED1's significance varies among cancer types; it has been studied extensively in breast cancer, where its expression levels can correlate with prognosis.

What clinical implications does the overexpression of MED1 have in cancer treatment? 06/16/2021

Elevated MED1 levels may influence the response to certain cancer therapies, making it a potential biomarker for treatment outcomes.

How does understanding MED1 protein function contribute to personalized medicine approaches in cancer treatment? 09/02/2020

Tailoring cancer treatments based on the molecular characteristics of MED1 and its interactions can enhance the efficacy of personalized medicine strategies.

How is the expression of MED1 protein linked to cancer development? 08/06/2017

Aberrant expression of MED1 has been associated with various cancers, where it can either promote or suppress tumor growth depending on the context.

In what ways does MED1 protein interact with hormone receptors, and what implications does this have for endocrine-related diseases? 11/19/2016

MED1 interacts with hormone receptors, impacting hormonal signaling pathways, and dysregulation of these interactions is implicated in endocrine-related diseases, including hormonal cancers.

Customer Reviews (3)

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Reviews
01/04/2023

    Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.

    04/26/2019

      The MED1 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

      06/17/2017

        This flexibility enables researchers like myself to tailor MED1 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.

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