MED1
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Official Full Name
mediator complex subunit 1
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Overview
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008] -
Synonyms
MED1; mediator complex subunit 1; PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220; mediator of RNA polymerase II transcription subunit 1; ARC205; TRIP-2; PPAR binding protein; PPAR-binding protein; PPARG binding protein; TR-interacting protein 2; p53 regulatory protein RB18A; thyroid receptor interacting protein 2; thyroid receptor-interacting protein 2; vitamin D receptor-interacting protein 230 kD; activator-recruited cofactor 205 kDa component; peroxisome proliferator-activated receptor-binding protein; vitamin D receptor-interacting protein complex component DRIP205; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- SUMO
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | MED1-800H | Recombinant Human MED1, GST-tagged | E.coli | GST | 207-556aa | |
Human | MED1-01H | Recombiant Human MED1 Protein Lysate | HEK293T | |||
Human | MED1-436H | Recombinant Human MED1 Protein, His-tagged | E.coli | His | Met1~Thr212 | |
Human | MED1-4421H | Recombinant Human MED1 protein, His-SUMO-tagged | E.coli | His-SUMO | 878-1031aa | |
Mouse | MED1-9679M | Recombinant Mouse MED1 Protein | Mammalian Cell | His | ||
Mouse | MED1-5440M-B | Recombinant Mouse MED1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | MED1-5440M | Recombinant Mouse MED1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- MED1 Related Research Area
MED1 involved in several pathways and played different roles in them. We selected most pathways MED1 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Thyroid hormone signaling pathway | ATP1B3;SLC9A1;RXRG;RXRA;ATP1A1;PFKFB2;PDPK1;MED12;PIK3R2 |
MED1 has several biochemical functions, for example, LBD domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED1 itself. We selected most functions MED1 had, and list some proteins which have the same functions with MED1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
LBD domain binding | MED1;PROX1;CITED2;CITED1 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | KLF17;NFE2L3;MXD1;CDX4;NR2C1;RFX2;ELF3;ZNF100;FEZF2 |
RNA polymerase II transcription cofactor activity | MED21;MED15;MED8;MDT-19;MED7;FOXH1;MED20;PPRC1;MED30 |
RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXD5;ZNF446;TRP53;ETV6;ELF2A;ZNF174;FOXJ1A;FOXA3;TWIST1 |
chromatin DNA binding | HIST1H1E;EZH2;HDAC3;APEX1;CLOCK;MYOD1;NEUROG3;GRHL3;INSM1A |
chromatin binding | JDP2;GATA3;SUPT5H;KDM8;CRX;POU1F1;HDAC7;ARNTL1B;SIN3B |
core promoter binding | HNRNPU;GATA1;IFI203;AGO2;MED1;HDAC6;EZH2;E2F8;TFAP2C |
estrogen receptor binding | PCNA;LEF1;DYX1C1;PADI2;DDX5;TAF10;ARRB1;NRIP1;MMS19 |
ligand-dependent nuclear receptor binding | NCOA2;ISL1;NCOA3;TRIM24;NCOR2;BAZ2A;SMARCE1;MED1;TRIP4 |
ligand-dependent nuclear receptor transcription coactivator activity | PSMC3IP;NCOA1;SMARCD3;NCOA2;TADA3;PUS1;BUD31;PPARGC1A;KDM1A |
mediator complex binding | SMC3;MED1;NIPBL;SMC1A |
nuclear hormone receptor binding | SMARCD3;SNW1;NRIP1;TCF7L2;NCOR1;MED1;MYOD1;CRX;EP300 |
peroxisome proliferator activated receptor binding | ASXL1;PPARGC1A;PRMT2;NFATC4;MED1;HMGA1;CREBBP;ASXL2;EP300 |
protein binding | RNF180;CYP4F2;C3orf62;FAM124B;COX8A;CLIP1;C15orf57;TM4SF4;FAM71C |
receptor activity | RAMP1;FAS;MED24;CADM4;GABRA5;LILRA3;TLR1;GRIN1B;ITGB1B.2 |
retinoic acid receptor binding | RXRA;MED25;PRAMEF1;HMGA1-RS1;SNW1;ASXL1;PRAMEF10;HMGA1;CTBP2 |
thyroid hormone receptor binding | MED24;MED17;NSD1;THRAP3;NR0B2;TAF7;TRIP12;ZNHIT3;HMGN3 |
thyroid hormone receptor coactivator activity | MED16;ACTN2;MED1;NCOA2 |
transcription coactivator activity | MKL1B;MTA1;LPIN1;CITED4;WWC1;MED26;RNF20;PCBD1;GABPA |
transcription cofactor activity | POU2AF1;MED30;ANKRA2;RFXANK;MSX2;ZNF710A;NSD1;LDB2B;ZNF763 |
transcription factor binding | PPRC1;PRICKLE1;TRIB1;TAF12;PELP1;HES6;TAF7;RNF222;NKX2-5 |
ubiquitin protein ligase activity | HLTF;ANKIB1;MDM2;MARCH1;RNF14;HERC6;DZIP3;UBE2S;UBE2G1B |
vitamin D receptor binding | MED14;MED1;TAF11;MED24;RXRA;MED16;SNW1;MED30;TAF7 |
MED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED1.
MED10; CDK8; MED19; THRA
- Q&As
- Reviews
Q&As (5)
Ask a questionMED1's significance varies among cancer types; it has been studied extensively in breast cancer, where its expression levels can correlate with prognosis.
Elevated MED1 levels may influence the response to certain cancer therapies, making it a potential biomarker for treatment outcomes.
Tailoring cancer treatments based on the molecular characteristics of MED1 and its interactions can enhance the efficacy of personalized medicine strategies.
Aberrant expression of MED1 has been associated with various cancers, where it can either promote or suppress tumor growth depending on the context.
MED1 interacts with hormone receptors, impacting hormonal signaling pathways, and dysregulation of these interactions is implicated in endocrine-related diseases, including hormonal cancers.
Customer Reviews (3)
Write a reviewTheir commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.
The MED1 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.
This flexibility enables researchers like myself to tailor MED1 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.
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