med23
Share
  • Official Full Name
  • mediator complex subunit 23
  • Background
  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms
  • MED23; mediator complex subunit 23; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa , CRSP3; mediator of RNA polymerase II transcription subunit 23; CRSP130; DRIP130; Sur2; 130 kDa transcriptional co activator; 133 kDa transcriptional co activator; Activator recruited cofactor 130 kDa component; ARC 130; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa mediator; Cofactor required for Sp1 transcriptional activation subunit 3; CRSP 130; CRSP 130 kD subunit; CRSP 133; CRSP 3; CRSP complex subunit 3; CRSP133; CRSP3; CRSP3 protein; DKFZp434H0117; DRIP 130; KIAA1216; MED 23; SUR 2; Transcriptional co activator CRSP 130; Transcriptional co activator CRSP130; Vitamin D3 receptor interacting protein; Vitamin D3 receptor interacting protein complex 130 kDa component; 130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; activator-recruited cofactor 130 kDa component; MRT18; SUR-2
Cat.#:MED23-1906HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED23 Protein, GST-tagged
+Inquiry
Cat.#:MED23-809HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED23, GST-tagged
+Inquiry
Cat.#:MED23-2722RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MED23 Protein, His-tagged
+Inquiry
Cat.#:MED23-1189ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED23
+Inquiry

Involved Pathway

MED23 involved in several pathways and played different roles in them. We selected most pathways MED23 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED23 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
EZRA; TDGF1; CACNG2B; TCF3A; FGFR1B; KALRN; LGI2; FRS2B; UNC5D; EFNA1
Fatty acid, triacylglycerol, and ketone body metabolism
MED19; CTGF; AGPAT2; CDK19; YAP1; CDK8; TMEM195; ANKRD1; Agmo; GLIPR1
Gene Expression
APOBEC1; ZNF2; LSM6; ZNF671; ZNF192; TSNAX; RARG; CBX3A; ESRRGA; NR6A1
Generic Transcription Pathway
ZNF597; VDRB; ZNF549; ZNF79; ZFP1; NR6A1; ZNF599; ZNF484; CDK8; ZNF12
Metabolism
AZIN1A; Alb; UGT1B1; ABHD3; SULT1C4; AGL; TREH; AWAT1; ADK; NUDT10
Metabolism of lipids and lipoproteins
CYP11B1; ACOT12; GLTPA; GLIPR1; ECI1; ACAD11; FABP11A; MED31; ARSE; APOA4A
PPARA activates gene expression
CTGF; MED16; CDK19; SREBF2; PLIN2; MED15; APOA5; MED7; MED8; MTF1
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
MED9; MED20; MED10; MED16; MED25; CDK19; MED23; ANKRD1; GRHL1; G0S2

Protein Function

MED23 has several biochemical functions, for example, protein binding, transcription coactivator activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED23 itself. We selected most functions MED23 had, and list some proteins which have the same functions with MED23. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein MX2; USP12; MYOM1; MYL2; MTAP1B; FIBCD1; DNAJB5; NKAP; EPHA10; SSX2
Function transcription coactivator activity
Related Protein AIP; MMS19; JUNBB; RNF20; TFDP1B; TUBB3; SOX10; E4F1; PCBD1; JUNBA
Function ubiquitin protein ligase activity
Related Protein ZSWIM2; ITCH; UBE2V2; SIAH1; FBXO6; UBE2NA; FBXO30; ANKIB1; UBE2H; UBE2J1

Interacting Protein

MED23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED23 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED23.
MED10; CDK19; MED19; MED26; CDK8; MED14; MED25; MED16; rluC; pyrG