• Official Full Name
  • myelin protein zero-like 2
  • Background
  • Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • MPZL2; myelin protein zero-like 2; epithelial V like antigen 1 , EVA1; myelin protein zero-like protein 2; EVA; Epithelial V like antigen 1; EVA1; MPZL2 myelin protein zero like 2; Myelin protein zero like protein 2; epithelial V-like antigen 1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MPZL2 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MPZL2
Source (Host):Species:Human
Product nameRecombinant Human MPZL2 293 Cell Lysate

Protein Function

MPZL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MPZL2 itself. We selected most functions MPZL2 had, and list some proteins which have the same functions with MPZL2. You can find most of the proteins on our site.
Related Protein
Function protein binding
Related Protein TRPC2; RAB7A; FARSA; SGOL1; SH2D3A; FBXW7; FAM109B; OFD1; IL15; APOB

Interacting Protein

MPZL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPZL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MPZL2.
MPZL3; ATF4; MEST; b3xyc5_sollc

MPZL2 Related Articles

Wang, FF; Wang, L; et al. PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells. MOLECULAR MEDICINE REPORTS 11:698-704(2015).
Nakata, H; Wakayama, T; et al. Compensatory Upregulation of Myelin Protein Zero-Like 2 Expression in Spermatogenic Cells in Cell Adhesion Molecule-1-Deficient Mice. ACTA HISTOCHEMICA ET CYTOCHEMICA 45:47-56(2012).