Recombinant Human MPZL2 Protein, GST-tagged

• Cat.No.: MPZL2-5526H
• Product Overview: Human MPZL2 full-length ORF ( NP_005788.1, 1 a.a. - 215 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 50.9 kDa
• AA Sequence: MYGKSSTRAVLLLLGIQLTALWPIA AVEIYTSRVLEAVNGTDARLKCTFS SFAPVGDALTVTWNFRPLDGGPEQF VFYYHIDPFQPMSGRFKDRVSWDGN PERYDASILLWKLQFDDNGTYTCQV KNPPDVDGVIGEIRLSVVHTVRFSE IHFLALAIGSACALMIIIVIVVVLF QHYRKKRWAERAHKVVEIKSKEEER LNQEKKVSVYLEDTD
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MPZL2 myelin protein zero-like 2 [ Homo sapiens ]
• Official Symbol: MPZL2
• Synonyms: MPZL2; myelin protein zero-like 2; epithelial V like antigen 1 , EVA1; myelin protein zero-like protein 2; EVA; epithelial V-like antigen 1; EVA1
• Gene ID: 10205
• mRNA Refseq: NM_005797
• Protein Refseq: NP_005788
• MIM: 604873
• UniProt ID: O60487