• Official Full Name
  • nuclear prelamin A recognition factor
  • Background
  • Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
  • Synonyms
  • NARF; nuclear prelamin A recognition factor; DKFZp434G0420; FLJ10067; IOP2; iron only hydrogenase like protein 2; iron-only hydrogenase-like protein 2; prenyl-dependent prelamin A binding protein
Source (Host):HEK293Species:Human
Product nameRecombinant Human NARF Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NARF, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NARF Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NARF Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NARF
Source (Host):HEK293Species:Human
Product nameRecombinant Human NARF lysate

Protein Function

NARF has several biochemical functions, for example, NOT NADH dehydrogenase activity, NOT iron-sulfur cluster binding, lamin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NARF itself. We selected most functions NARF had, and list some proteins which have the same functions with NARF. You can find most of the proteins on our site.
Related Protein
Function NOT NADH dehydrogenase activity
Related Protein NARF
Function NOT iron-sulfur cluster binding
Related Protein NARF
Function lamin binding
Related Protein SUN1; IFI27; BNIP3L; LBR; PPP4C; TOR1AIP1; NARF; PLCB1; TMPO; TMEM201

Interacting Protein

NARF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NARF here. Most of them are supplied by our site. Hope this information will be useful for your research of NARF.
SFRP4; q7ard3_yerpe; PRPF4; PTBP3; Nedd1; CBX5; Espl1; Ppp4c; TOR1AIP1; Vangl1; ENTHD2; Rab11fip1; Ranbp2; ACTR5; Mtmr2

NARF Related Articles

Song, DS; Lee, FS; et al. Mouse Knock-out of IOP1 Protein Reveals Its Essential Role in Mammalian Cytosolic Iron-Sulfur Protein Biogenesis. JOURNAL OF BIOLOGICAL CHEMISTRY 286:-(2011).
Song, DS; Tu, Z; et al. Human ISCA1 Interacts with IOP1/NARFL and Functions in Both Cytosolic and Mitochondrial Iron-Sulfur Protein Biogenesis. JOURNAL OF BIOLOGICAL CHEMISTRY 284:35297-35307(2009).