pim2
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  • Official Full Name
  • proviral integration site 2
  • Background
  • PIM-2 belongs to a family of cytoplasmic serine/threonine protein kinases that consists of two other members, PIM-1 and PIM-3. Expression of this protein is regulated by hematopoietic cytokines. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It is also highly expressed in human leukemic and lymphoma cell lines. The gene is also expressed in primary spermatocytes. The results suggest a role for PIM-2 in proliferating cells as well as during meiosis. PIM-2 is thought to be a mediator of p53 mediated apoptosis inhibition by interleukin 3, which supports its role in the formation of various tumors including lymphomas.
  • Synonyms
  • PIM2; proviral integration site 2; serine/threonine-protein kinase pim-2; Pim-2; DXCch3
Cat.#:PIM2-1721HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIM2, GST-tagged
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Cat.#:PIM2-206HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIM2, His-tagged
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Cat.#:PIM2-29589THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIM2
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Cat.#:PIM2-12816MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIM2 Protein
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Cat.#:Pim2-1503MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pim2 protein, His & T7-tagged
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Cat.#:Pim2-1504RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pim2 protein, His & T7-tagged
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Cat.#:PIM2-3437RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIM2 Protein, His-tagged
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Cat.#:PIM2-1456HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIM2 (Active), GST-tagged
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Cat.#:PIM2-393HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Pim-2 Oncogene, GST-tagged, Active
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Cat.#:PIM2-727HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Pim-2 Oncogene, GST-His
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Cat.#:PIM2-3180HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIM2 293 Cell Lysate
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Involved Pathway

PIM2 involved in several pathways and played different roles in them. We selected most pathways PIM2 participated on our site, such as Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIM2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Acute myeloid leukemia
MAP2K2; MAPK3; MTOR; PML; CCNA1; MAPK1; EIF4EBP1; BAD; SFPI1; KIT

Protein Function

PIM2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIM2 itself. We selected most functions PIM2 had, and list some proteins which have the same functions with PIM2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein LARS; ATP1A1A.4; MYO1A; CHD7; EIF4A2; PSTK; MAP4K6; OAS3; DDX42; PAPOLB
Function protein binding
Related Protein BRD7; EIF4EBP3L; PRAP1; TNIK; MOXD1; ZNF335; SATB1; MS4A1; S100A13; CSNK1A1
Function protein serine/threonine kinase activity
Related Protein SGK1; PKN2; FASTK; CDKL5; TGFBR1B; PIM1; MAP3K9; STK30; MAPK11; RIPK4

Interacting Protein

PIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIM2.
ZNF821; MDM2; IKBKG; HSP90AB1; q96bx3_human; NDUFB8; HNRNPH3; RPL21; GSK3B; ATXN1; FBXO18; NUP98; PPIL2; CCDC84; PRCC; GPKOW; TOE1; CLK4

PIM2 Related Articles

Jiang, YW; Soong, TD; et al. Genome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma. PLOS ONE 7:-(2012).
Hallermann, C; Niermann, C; et al. New prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 56:588-597(2007).