PIM2

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PIM2

Official Full Name proviral integration site 2
Background PIM-2 belongs to a family of cytoplasmic serine/threonine protein kinases that consists of two other members, PIM-1 and PIM-3. Expression of this protein is regulated by hematopoietic cytokines. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It is also highly expressed in human leukemic and lymphoma cell lines. The gene is also expressed in primary spermatocytes. The results suggest a role for PIM-2 in proliferating cells as well as during meiosis. PIM-2 is thought to be a mediator of p53 mediated apoptosis inhibition by interleukin 3, which supports its role in the formation of various tumors including lymphomas.
Synonyms PIM2; proviral integration site 2; serine/threonine-protein kinase pim-2; Pim-2; DXCch3
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PIM2-1456H Recombinant Human PIM2 (Active), GST-tagged Sf9 Insect Cell GST
    Human PIM2-1721H Recombinant Human PIM2, GST-tagged E.coli GST
    Human PIM2-206H Recombinant Human PIM2, His-tagged E.coli His
    Human PIM2-29589TH Recombinant Human PIM2 N/A
    Human PIM2-3180HCL Recombinant Human PIM2 293 Cell Lysate HEK293 N/A
    Human PIM2-393H Recombinant Human Pim-2 Oncogene, GST-tagged, Active Sf9 Insect Cell GST
    Human PIM2-727H Recombinant Human Pim-2 Oncogene, GST-His Sf9 Insect Cell GST
    Mouse PIM2-12816M Recombinant Mouse PIM2 Protein Mammalian Cell His
    Mouse Pim2-1503M Recombinant Mouse Pim2 protein, His & T7-tagged E.coli His/T7
    Rat Pim2-1504R Recombinant Rat Pim2 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque PIM2-3437R Recombinant Rhesus monkey PIM2 Protein, His-tagged Mammalian Cell His

    PIM2 involved in several pathways and played different roles in them. We selected most pathways PIM2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Acute myeloid leukemia GRB2; BRAF; SOS1; CEBPA; RUNX1T1; IKBKB; MAP2K2; PIK3R5; MAPK3; NFKB1

    PIM2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PIM2 itself. We selected most functions PIM2 had, and list some proteins which have the same functions with PIM2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP2K5; MYH1; TRPM4; TEC; EPHA5; FAM120B; TTLL4; IDE; TK1; STK32B
    protein binding PPP2R4; TEAD1; SERPINB9; SNX11; SERPINE2; LRRC26; DGAT1; SNRPA; DRG1; SCUBE3
    protein serine/threonine kinase activity GSK3B; CLK4; PLK3; CSNK1DA; RPS6KA3; MARK1; STK32C; ALPK1; MAP4K5; TSSK6

    PIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIM2.

    ZNF821; MDM2; IKBKG; HSP90AB1; q96bx3_human; NDUFB8; HNRNPH3; RPL21; GSK3B; ATXN1; FBXO18; NUP98; PPIL2; CCDC84; PRCC; GPKOW; TOE1; CLK4

    Jiang, YW; Soong, TD; et al. Genome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma. PLOS ONE 7:-(2012).
    Hallermann, C; Niermann, C; et al. New prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 56:588-597(2007).

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