ppp3ca
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  • Official Full Name
  • protein phosphatase 3, catalytic subunit, alpha isozyme
  • Background
  • Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and calcium-dependent serine-threonine phosphatase, and formerly known as protein phosphatase 2B (PP2B).It activates the T cells of the immune system and can be blo
  • Synonyms
  • PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme; CALN, CALNA, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); serine/thr
Cat.#:PPP3CA-5255HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA/PPP3R1 Protein
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Cat.#:PPP3CA&PPP3R1-626HTag:
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PPP3CA&PPP3R1
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Cat.#:PPP3CA-158HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PPP3CA
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Cat.#:PPP3CA-1922HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, GST-tagged
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Cat.#:PPP3CA-26743THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, His-tagged
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Cat.#:PPP3CA-7365HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3CA, His tagged
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Cat.#:PPP3CA-951HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, His-tagged
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Cat.#:PPP3CA-4639RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3CA Protein
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Cat.#:PPP3CA-3576RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPP3CA Protein, His-tagged
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Cat.#:PPP3CA-7831ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP3CA
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Cat.#:PPP3CA-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3CA cell lysate
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Involved Pathway

PPP3CA involved in several pathways and played different roles in them. We selected most pathways PPP3CA participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CDC42L; CACNG6A; CASP3A; TGFB1A; PRKACA; PDGFB; MINK1; FGF1A; CACNA1B; FGF11
Calcium signaling pathway
PPP3R1; PLCG1; GRIN2C; P2RX8; TBXA2R; TRHR2; HTR2A; PTGER1A; P2RX6; GNAL
cGMP-PKG signaling pathway
GNA12; GNAI2; AGTR1A; INSR; PPP1CB; PPP1CC; ATP1A2; NFATC2; ATP1B2; INS1
Oocyte meiosis
CPEB1A; Ar; CPEB1; PPP2R1A; CAMK2D1; ANAPC1; PPP1CBL; STAG3; CDC16; SMC1B
Apoptosis
PRKACAB; XIAP; CASP3A; HIST1H1A; FADD; TRAF2; HRK; IRF2; BIRC2; PPP3CCA
Wnt signaling pathway
DVL1B; PSEN1; RAC3B; DVL3A; PRKACAA; RAC3; PPP3CCB; MAPK8A; RHOAD; WNT7A
Axon guidance
SEMA5A; ROCK2; EPHB2; ROCK1; ACTR2; PTPRA; ABLIM2; CDK5R1B; SIAH2; LRRC4
VEGF signaling pathway
PLA2G4D; RAC3B; AKT3A; PRKCBB; PXNA; PTK2AA; SRC; RAF1B; BAD; RAC3A
Osteoclast differentiation
TGFBR2; FOSL2; IL1R1; TNFRSF11A; SYK; PIK3R5; TNFRSF11B; TNFSF11; PIK3CB; SIRPG
Natural killer cell mediated cytotoxicity
KIR2DL1; NCR3; PTK2B; PRKCB; NFATC2; HLA-G; RAET1G; KLRC3; IFNA12; CD48
T cell receptor signaling pathway
MAP2K1; PAK7; NRAS; CABIN1; PIK3R5; IL4; PIK3CB; AKT1; PPP3CC; PIK3CD
B cell receptor signaling pathway
RAC1; BCL10; PLEKHA2; FOS; PDPK1A; CDK4; ARPC5; MALT1; INPPL1; GSK3B
Long-term potentiation
MAP2K1; RAF1; GRIA1; CAMK2A; ATF4; CALML3; CALM3; MAPK3; PLCB1; BRAF
Glutamatergic synapse
PLA2G4A; GRIA3; SLC1A7; GNB3; GNAS; GRIK2; SLC17A8; GNAQ; PPP3CA; GNAI1
Dopaminergic synapse
GRIA1; CREB3L4; DRD3; CAMK2D; CREB3; PPP2CB; CREB5; GNAO1; CAMK2A; KCNJ5
Oxytocin signaling pathway
PRKAG3; CALML5; PPP3R2; Adcy4; CAMKK2; PIK3R2; PIK3CB; CACNA2D1; CAMK2B; NPR1
Glucagon signaling pathway
LDHAL6A; CAMK2A; PRKAA1; GYS1; PRKAG1; PRKACG; G6PC; CALM1; ACACA; PPP3CA
Renin secretion
PDE1B; NPR1; PRKACB; PDE1A; PLCB4; PPP3R2; CLCA5; GNAS; PPP3R1; GNAI2
Alzheimers disease
COX4I2; GRIN2D; LPL; NDUFS1; PLCB1; SDHC; NDUFS7; NDUFB7; NDUFA3; COX8A
Amyotrophic lateral sclerosis (ALS)
SOD1; RAC1; TNFRSF1A; CASP9; PPP3R1; TOMM40; DAXX; TOMM40L; BID; NEFH
Amphetamine addiction
CAMK2D; CREB3; PRKCA; PRKCB; DRD1; CALM3; CREB3L4; SLC18A1; CAMK2A; SIRT1
Tuberculosis
IFNA2; CEBPG; HSPD1; IL18; IL1B; IL12B; MAPK3; Ifna15; IL10RB; LAMP2
HTLV-I infection
WNT3A; PDGFA; NFATC4; PIK3CD; VDAC1; NFATC3; IL15RA; NFKB1; SMAD2; EGR1

Protein Function

PPP3CA has several biochemical functions, for example, calcium ion binding, calmodulin binding, calmodulin-dependent protein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CA itself. We selected most functions PPP3CA had, and list some proteins which have the same functions with PPP3CA. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CALR3; EFEMP2A; RAB11FIP3; MMP17; FSTL1A; S100A1; CAPN12; CCDC102A; S100A8; PCDHGB3
Function calmodulin binding
Related Protein ATP2B1; SLC8A2; GEM; SRY; PHKB; MARCKSL1B; CNGA2; PATE4; CAMKV; ATPIF1
Function calmodulin-dependent protein phosphatase activity
Related Protein PPM1F; PPP3CB; PPP3CA; PPM1A
Function drug binding
Related Protein CHRM2; GLRB; SMO; PPP3CA; P2RX1; PPARD; RARB; DRD4; PPARA; CHRNB4
Function enzyme binding
Related Protein XRCC1; DAOA; ATP2A2; HIST1H2AI; SLC12A3; KALRN; RYR2; HSPA8; YWHAE; ARPC4
Function protein binding
Related Protein PSTPIP1; KCNJ10; RCN1; ITPKB; TSC1; ANKRD17; NCF4; H2AFY; VDAC1; FGFRL1A
Function protein dimerization activity
Related Protein TFEC; GGN; NEUROG2; MESPBB; HES2.2; ARNTL; BHLHE41; MYCA; ASCL3; HER5
Function protein heterodimerization activity
Related Protein TAF4B; TFAP2E; UGT1A6; PBX1; SYT14; MLXIPL; UGT1A3; SLC51B; EXT1; ATF6
Function protein serine/threonine phosphatase activity
Related Protein PPM1B; PPP5C; MTMR3; PPM1L; PPM1DA; PPA2; CDKN3; PHLPP2; EPM2A; PPP1R3D

Interacting Protein

PPP3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CA.
PPP3R1; GRB2; C16orf74; Cacng8; USP14; LASP1; Kcnj8; Nfatc1; ABL1