ppp3ca
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  • Official Full Name
  • protein phosphatase 3, catalytic subunit, alpha isozyme
  • Background
  • Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and calcium-dependent serine-threonine phosphatase, and formerly known as protein phosphatase 2B (PP2B).It activates the T cells of the immune system and can be blo
  • Synonyms
  • PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme; CALN, CALNA, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); serine/thr
Cat.#:PPP3CA-5255HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA/PPP3R1 Protein
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Cat.#:PPP3CA&PPP3R1-626HTag:
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PPP3CA&PPP3R1
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Cat.#:PPP3CA-158HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PPP3CA
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Cat.#:PPP3CA-1922HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, GST-tagged
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Cat.#:PPP3CA-26743THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, His-tagged
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Cat.#:PPP3CA-7365HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3CA, His tagged
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Cat.#:PPP3CA-951HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, His-tagged
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Cat.#:PPP3CA-4639RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3CA Protein
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Cat.#:PPP3CA-3576RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPP3CA Protein, His-tagged
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Cat.#:PPP3CA-7831ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP3CA
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Cat.#:PPP3CA-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3CA cell lysate
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Involved Pathway

PPP3CA involved in several pathways and played different roles in them. We selected most pathways PPP3CA participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPKAPK5; PRKACBA; Fgf15; MAPKAPK3; PRKACBB; MAPK12B; MAPK9; ARRB1; CACNB2; PPP3CC
Calcium signaling pathway
CCKBR; P2RX4; GNA14; BDKRB1; ADRa1A; TACR1; PRKACAB; MYLK4; TMEM8C; SLC25A5
cGMP-PKG signaling pathway
CREB3L3; IRS1; INSR; NPR2; PRKG1; BAD; CREB3L1; CALM1; PIK3R2; Adcy4
Oocyte meiosis
CAMK2B1; FBXO5; AURKA; CALM4; PPP2R5C; Ar; PPP3R1B; CALM1A; MOS; SMC3
Apoptosis
BIRC8; TNFRSF10A; PPP3R1; BAX; PIK3R3A; GZMC; DAPK1; NFKBIAB; PPP3CA; DNM1L
Wnt signaling pathway
WNT9B; CAMK2A; PRKCA; WNT2BB; CAMK2G; TCF7; RHOA; MAPK8A; NKD2B; CCND3
Axon guidance
SEMA6C; CSF2RA; PAQR3A; EPHA2; DUSP7; GFRA4; PEA15; LAMTOR2; PTPRA; SIAH2
VEGF signaling pathway
BAD; PLA2G4F; KRAS; PRKCBB; CDC42L2; HRASB; SPHK1; PTGS2B; PTK2; PPP3CC
Osteoclast differentiation
MAP3K7; FYN; IL1A; MAPK12; PIK3R1; CSF1R; FCGR2A; TRAF6; SIRPB1; NFATC2
Natural killer cell mediated cytotoxicity
BRAF; IFNB1; MICA; ITGB2; MICB; PIK3R1; IFNA2; ICAM2; HLA-C; FCGR3B
T cell receptor signaling pathway
PIK3CG; CDC42; IFNG; PAK1; PIK3R1; IL5; MAPK9; PTPN6; DEF6A; AKT1
B cell receptor signaling pathway
DUSP6; MAPK4; NFATC2; BCL10; PILRB; RAC2; VAV1; ACTR2; cgr2b; SLA2
Long-term potentiation
PRKCA; MAP2K2; PPP3CC; GRIN2B; RAF1; CALM3; PLCB1; CAMK2B; GRM5; CAMK4
Glutamatergic synapse
GLS2; PLA2G4D; GRIN2B; GNG3; SLC38A3; SHANK1; SLC1A7; GRIN1; ADRBK2; GNAQ
Dopaminergic synapse
GNB1; PRKACG; PRKCG; KIF5C; CALM1; PRKCB; PPP2R5A; MAPK13; PRKACB; CREB3L1
Oxytocin signaling pathway
ACTB; PPP1CA; MYLK2; CALM4; PLA2G4A; PLA2G4C; ELK1; CAMK2D; MYL6; PPP1CB
Glucagon signaling pathway
CREB3L3; LDHAL6B; PPP3CC; PHKB; CAMK2G; LDHAL6A; PRKAA2; G6PC2; PDHA2; ITPR3
Renin secretion
PLCB1; CLCA3; PDE1C; PLCB3; PPP3CA; GNAI3; CLCA4; AGTR1A; GNAI2; PRKACB
Alzheimers disease
GAPDH; CALM3; PPP3CB; APP; ATP5G1; APOE; GRIN2C; COX7A2L; NDUFC2-KCTD14; ATP2A2
Amyotrophic lateral sclerosis (ALS)
CAT; TNF; TRP53; MAPK14; BAX; PPP3CC; GRIN1; MAP3K5; RAC1; GPX1
Amphetamine addiction
SIRT1; ATF4; PPP3CC; CREB3L4; CALM2; HDAC1; PPP3CA; FOSB; PRKACB; GRIN2C
Tuberculosis
AKT2; BCL10; TRAF6; HLA-DRB5; TGFB3; TLR1; HLA-DQA1; LAMP2; IL18; CALM4
HTLV-I infection
TBP; HLA-G; WNT2B; MRAS; TLN1; STAT5A; POLD2; PIK3R1; TBPL1; NRAS

Protein Function

PPP3CA has several biochemical functions, for example, calcium ion binding, calmodulin binding, calmodulin-dependent protein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CA itself. We selected most functions PPP3CA had, and list some proteins which have the same functions with PPP3CA. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PLA2G10; MICU1; MYLPFB; RHBDL3; S100A2; LRP4; PCDH2AA1; SYT12; TPM4; THBS2
Function calmodulin binding
Related Protein CTH; PCDP1; PHKA1; DCX; TRPM4; STRN; NRGNA; TRPV1; SNTA1; NRGN
Function calmodulin-dependent protein phosphatase activity
Related Protein PPP3CA; PPM1A; PPM1F; PPP3CB
Function drug binding
Related Protein NAMPT; CYP4B1; DAAM2; CHRM2; CYP2C9; CHRNB3; PDE4C; PYGM; GLRB; HTR2B
Function enzyme binding
Related Protein NR5A1; PLAUR; UGT1A9; PEX5; TOP2A; MDM4; PTEN; CBS; PHKG2; GSTM2
Function protein binding
Related Protein C16orf53; FGF10; C7orf42; KRT40; KCNA2; LARP1; GMNN; BLM; ZNF167; ACOT7
Function protein dimerization activity
Related Protein MAX; TFAP2C; AHRRA; MEF2CA; NPAS1; SMG1; ZBED4; POLR1D; ASCL2; NCOA1
Function protein heterodimerization activity
Related Protein BCL2A1A; TPD52L2; CD3E; LIFR; IRAK2; HIST1H2AL; JAM3; PIK3R2; SDCBP2; SOX32
Function protein serine/threonine phosphatase activity
Related Protein PPP5C; PPP1R3D; PPM1B; PDP1; PPM1LB; PPM1AB; PPM1BA; EPM2A; PPM1AA; MTMR6

Interacting Protein

PPP3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CA.
PPP3R1; GRB2; C16orf74; Cacng8; USP14; LASP1; Kcnj8; Nfatc1; ABL1