ppp3ca
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  • Official Full Name
  • protein phosphatase 3, catalytic subunit, alpha isozyme
  • Background
  • Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and calcium-dependent serine-threonine phosphatase, and formerly known as protein phosphatase 2B (PP2B).It activates the T cells of the immune system and can be blo
  • Synonyms
  • PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme; CALN, CALNA, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); serine/thr
Cat.#:PPP3CA-5255HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA/PPP3R1 Protein
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Cat.#:PPP3CA&PPP3R1-626HTag:
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PPP3CA&PPP3R1
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Cat.#:PPP3CA-158HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PPP3CA
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Cat.#:PPP3CA-1922HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, GST-tagged
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Cat.#:PPP3CA-26743THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, His-tagged
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Cat.#:PPP3CA-7365HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3CA, His tagged
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Cat.#:PPP3CA-951HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3CA, His-tagged
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Cat.#:PPP3CA-4639RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3CA Protein
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Cat.#:PPP3CA-3576RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPP3CA Protein, His-tagged
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Cat.#:PPP3CA-7831ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP3CA
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Cat.#:PPP3CA-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3CA cell lysate
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Involved Pathway

PPP3CA involved in several pathways and played different roles in them. We selected most pathways PPP3CA participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
AKT3A; CACNB2; FGFR3; FGF6; RAP1A; MAP3K11; FGF11A; TAOK2; MAP3K12; PDGFA
Calcium signaling pathway
EDNRAA; PLN; HTR2A; OXTR; PRKACG; RYR2; DRD1B; PRKACAA; GNAS; GRIN1A
cGMP-PKG signaling pathway
NOS3; CREB5; SLC25A6; INSR; RAF1; CALML5; MYLK; GATA4; ATP2A2; PPP1R12A
Oocyte meiosis
MAP2K1; ANAPC5; ANAPC13; PPP3R2; CCNE1; BTRC; SKP1; SLKA; CDC27; PPP3CCA
Apoptosis
CTNNB1; IRAK4; ENDOG; AKT2; PPP3CCA; TNFRSF10B; DBNLB; HMGB2; HIST1H1D; BIDA
Wnt signaling pathway
FZD6; WIF1; CCND2; WNT11R; CSNK1A1L; WNT2; WNT10B; WNT3; PLCB4; Fzd4
Axon guidance
CSK; ROBO3; SEMA4A; COL4A5; NEFLB; GFRA1; SEMA6C; PAQR3B; SEMA3A; EPHB4B
VEGF signaling pathway
SRC; MAP2K1; MAPK12; PLA2G4C; AKT2; PIK3CA; RAC3; RAF1A; PRKCBA; HRASA
Osteoclast differentiation
FCGR1; IFNGR1; PPP3CA; MAPK8; MAP3K7; PIK3R1; BTK; SFPI1; NFATC1; LILRA1
Natural killer cell mediated cytotoxicity
KLRC1; PTPN6; PTPN11; ULBP1; KIR2DL1; KIR2DS4; SHC4; Fasl; KIR2DS5; KLRC2
T cell receptor signaling pathway
SHB; CARD11; MAPK3; PIK3CG; OXSR1A; LAT; CD3E; MAPK9; TNF; MAP3K14
B cell receptor signaling pathway
AKT2; PPP3R1; CD72; DOK3; NFKB1; ARPC3; CMTM3; DOK1B; SYK; BLK
Long-term potentiation
GRM5; PPP3R1; KRAS; CALM1; CALM2; MAPK1; CALML3; HRAS; PLCB3; CAMK2D
Glutamatergic synapse
PPP3CA; SHANK2; ITPR1; PLCB1; SLC1A3; HOMER1; PLA2G4A; GNG4; SLC38A3; PLCB3
Dopaminergic synapse
PPP2R5D; GRIN2A; CREB3L1; ITPR1; GNB1; KCNJ6; GNG11; KCNJ5; PLCB4; GNGT2
Oxytocin signaling pathway
ROCK1; ACTB; MAP2K1; PPP1R12C; MYLK2; PPP3CC; MYL9; PLA2G4D; PPP3CB; NFATC1
Glucagon signaling pathway
CREB5; PDE3B; PHKG1; CREB3L2; PPP3CC; GCGR; CALM3; LDHA; CAMK2A; SMEK2
Renin secretion
ITPR1; GNAQ; CALML5; AGTR1A; PDE1A; CLCA3; PLCB1; PRKACB; CALM1; LOC100328615
Alzheimers disease
PLCB4; SNCA; ATP2A3; Casp3; NDUFA7; UQCRB; NDUFB2; NDUFS4; GRIN2A; ATP5G3
Amyotrophic lateral sclerosis (ALS)
GRIA2; SLC1A2; CAT; PPP3R2; GRIN2B; CCS; TNFRSF1A; DAXX; MAPK13; TOMM40L
Amphetamine addiction
CALM4; PPP1CC; CAMK2D; CALM1; GRIA1; CALM3; PDYN; GRIN3B; CREB3; FOS
Tuberculosis
cgr2b; CALM3; Ifna15; MRC2; ATP6V0A1; NOS2; H2-AB1; FCGR3B; HLA-DQA2; FCGR3A
HTLV-I infection
FZD7; HLA-G; ANAPC11; RANBP3; CD40; WNT8A; ETS1; CD3E; CD3D; HRAS; ATM

Protein Function

PPP3CA has several biochemical functions, for example, calcium ion binding, calmodulin binding, calmodulin-dependent protein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CA itself. We selected most functions PPP3CA had, and list some proteins which have the same functions with PPP3CA. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein ANXA6; CRACR2B; NCALDB; Amy1; PLA2G2F; TNNC2; SYT4; CDK5R1; PCDHB2; CDH20
Function calmodulin binding
Related Protein RRAD; CDK5RAP2; MIP; PDE1B; MAPKAPK2B; MYH3; ORAI1; CNN3A; DCX; TRPV5
Function calmodulin-dependent protein phosphatase activity
Related Protein PPP3CA; PPP3CB; PPM1F; PPM1A
Function drug binding
Related Protein CHRNA3; CHRNA7; PDE4C; P2RX1; FNTB; CYP2C9; ADH1; SFRP1; DRD4; TLR8
Function enzyme binding
Related Protein GOT2; HOXA9; BCL10; CBX3; HIST1H2AD; ZNF346; BIRC7; TTN; KDM1A; APOA5
Function protein binding
Related Protein ORC4L; PRIMPOL; SAC3D1; DUSP26; AP5S1; PSMA5; AKR7A3; USP14; FBXO44; CALCRL
Function protein dimerization activity
Related Protein MAX; HIF1AL; HNF1BA; MEF2B; GGN; ASCL3; BETA3; POU2F3; MNT; ID2B
Function protein heterodimerization activity
Related Protein TAF4B; CD3D; CABYR; HIST2H2AC; GABPB2; IKZF1; GUCY1A3; ENO3; HIST3H2BB; THRA
Function protein serine/threonine phosphatase activity
Related Protein PDP1; CDC14C; PPP3CB; DUSP23; PDP2; PPP1R3C; PPM1B; PPP5C; CTDNEP1; PPP2R1A

Interacting Protein

PPP3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CA.
PPP3R1; GRB2; C16orf74; Cacng8; USP14; LASP1; Kcnj8; Nfatc1; ABL1