PPP3R1 Protein, protein phosphatase 3, regulatory subunit B, alpha


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Official Full Name protein phosphatase 3, regulatory subunit B, alpha
Background PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and
Synonyms PPP3R1; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), reg; calcineurin subunit B type 1; calcineurin B; type I (19kDa); CALNB1; CNB; CNB1; protein phosphatase 2B regulatory subunit B alpha; CANB1_HUMAN; Cna2; PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1; OTTHUMP00000201952; OTTHUMP00000201960; OTTHUMP00000201961; calcineurin B, type I (19kDa); protein phosphatase 3 (formerly 2B), regulato
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPP3CA&PPP3R1-626H Recombinant Human PPP3CA&PPP3R1 Sf21 Insect Cell N/A
    Human PPP3R1-001HCL Recombinant Human PPP3R1 cell lysate Insect Cell N/A
    Human PPP3R1-1119H Recombinant Human PPP3R1 protein, His & GST-tagged E.coli His/GST
    Human PPP3R1-1923H Recombinant Human PPP3R1, GST-tagged E.coli GST
    Human PPP3R1-27208TH Recombinant Human PPP3R1, His-tagged E.coli His
    Human PPP3R1-3471H Recombinant Human PPP3R1, His-tagged E.coli His
    Human PPP3R1-7366H Recombinant Human PPP3R1, His tagged Insect Cell His
    Mouse PPP3R1-13269M Recombinant Mouse PPP3R1 Protein Mammalian Cell His
    Rat PPP3R1-4641R Recombinant Rat PPP3R1 Protein Mammalian Cell His
    Chicken PPP3R1-5946C Recombinant Chicken PPP3R1 Mammalian Cell His

    PPP3R1 involved in several pathways and played different roles in them. We selected most pathways PPP3R1 participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway RAC2; FGF13; FGF12A; TGFBR1A; CDC25B; NR4A1; FGFR1A; FGF14; PPP3R1B; PPP3R1
    Calcium signaling pathway ADORA2B; GNA11B; VDAC3; CHRM5A; ADRA1BB; P2RX7; CALM3; ERBB3A; CAMK2D2; EDNRBA
    cGMP-PKG signaling pathway CALM2; KCNMB3; KCNMB4; INS; CREB3L2; PDE5A; ITPR1; CREB3L1; PRKG1; PPP1R12A
    Oocyte meiosis PPP2R5A; CDC27; SGOL1; CAMK2D1; PGR; PPP1R2P9; REC8; PPP2R5CB; ANAPC2; SMC3
    Wnt signaling pathway RAC3A; DAAM1B; TBL1Y; NFATC4; PPARDB; PRKACAA; SIAH1A; RHOAC; FBXW11; DVL1B
    Axon guidance RHOA; RND1L; FRS3; GDNF; TRPC4; COL9A1B; EFNB3B; FYN; CSNK2A1; HBEGF
    VEGF signaling pathway CDC42L2; PLA2G4F; PIK3R2; SRC; RAC1; PRKCBB; MAPK11; MAPK12; AKT2L; MAPK12B
    Osteoclast differentiation IL1B; PIK3R3; TYROBP; FOSL2; FCGR2C; ITGB3; PIK3R2; FCGR4; GRB2; LCK
    Natural killer cell mediated cytotoxicity KIR2DS4; IFNA21; NCR1; LCK; IFNA12; NCR3; FASLG; BRAF; SHC4; MAP2K1
    T cell receptor signaling pathway PPP3R2; CD8B; CD40LG; BCL10; NCK2; DBNLB; PAK7; MAPK13; NFKBIA; PIK3R5
    B cell receptor signaling pathway CARD11; ARPC2; PPP3R2; BLK; ARPC1B; PIK3R3; LILRB3; HDAC5; NFKBIE; PIK3CG
    Long-term potentiation PPP1CA; PRKACB; MAP2K2; PPP3CB; CAMK4; CALM4; ITPR3; PRKCG; PPP1R1A; RAP1B
    Glutamatergic synapse HOMER2; GRIA3; GNG5; SLC1A2; GRIK3; GNAI1; SLC17A6; GNG13; GRIN3B; PLCB2
    Oxytocin signaling pathway EEF2K; RGS2; PIK3R3; OXT; CAMK2B; CACNA2D2; MYLK2; FOS; NFATC1; MAP2K2
    Glucagon signaling pathway PLCB4; EP300; PHKA2; PYGL; SIRT1; PLCB3; CALML3; ACACA; CAMK2D; PPP3R1
    Renin secretion CLCA1; PDE1C; Ren1; GNAS; REN; PDE1A; CALML3; NPR1; PTGER4; REN2
    Alzheimers disease APP; CASP12; ERN1; NDUFA4L2; CALM3; CASP8; NDUFA8; GAPDH; COX6A2; Casp3
    Amyotrophic lateral sclerosis (ALS) GRIA2; NEFM; APAF1; RAC1; CYCS; MAP3K5; TOMM40L; CASP1; GRIA1; BAD
    Amphetamine addiction SLC14A2; PRKCA; CALM1; PPP1CB; GRIN1; CREB3; CAMK2B; CREB5; CALML3; SLC18A2
    Tuberculosis TLR4; IFNB1; ATP6V0A2; HLA-DOA; MYD88; RAB7A; C3; HSPD1; CORO1A; RHOA
    HTLV-I infection BAX; MAPK8; WNT9B; POLD4; FOS; TBPL2; CRTC1; MSX2; PIK3R3; RRAS2

    PPP3R1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3R1 itself. We selected most functions PPP3R1 had, and list some proteins which have the same functions with PPP3R1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding EHD1B; CELSR2; PCDH2G16; CANT1A; CAPN8; S100A1; ANXA1; PCDHGB2; ASPN; THBS4A
    calcium-dependent protein serine/threonine phosphatase activity CAMK2G; PPP3R1; PPP3CB; NETO2
    calmodulin binding STRN4; MYLK2; MAPKAPK2A; CTH; CAMK2D1; SRY; KCNN1; STRN; VAMP2; CDK5RAP2
    protein binding INHBA; INTS10; ATPAF1; FAM111A; COBRA1; PFTK1; HENMT1; RPS6KA5; AHSA2; TMBIM6
    protein domain specific binding Akap2; PLXND1; HOMER2; PPARA; ZFP521; FOXH1; YWHAG1; MRPS31; NR0B2; NR0B1

    PPP3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3R1.


    Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).
    Pinheiro, CS; Staub, O; et al. Characterization and binding affinities of SmLANP: A new Schistosoma mansoni member of the ANP32 family of regulatory proteins. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 165:95-102(2009).

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