ppp3r1
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  • Official Full Name
  • protein phosphatase 3, regulatory subunit B, alpha
  • Background
  • PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and
  • Synonyms
  • PPP3R1; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), reg; calcineurin subunit B type 1; calcineurin B; type I (19kDa); CALNB1; CNB; CNB1; protein phosphatase 2B regulatory subunit B alpha; CANB1_HUMAN; Cna2; PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1; OTTHUMP00000201952; OTTHUMP00000201960; OTTHUMP00000201961; calcineurin B, type I (19kDa); protein phosphatase 3 (formerly 2B), regulato
Cat.#:PPP3CA&PPP3R1-626HTag:
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PPP3CA&PPP3R1
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Cat.#:PPP3R1-1119HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1 protein, His & GST-tagged
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Cat.#:PPP3R1-1923HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1, GST-tagged
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Cat.#:PPP3R1-27208THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1, His-tagged
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Cat.#:PPP3R1-3471HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1, His-tagged
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Cat.#:PPP3R1-7366HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3R1, His tagged
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Cat.#:PPP3R1-13269MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP3R1 Protein
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Cat.#:PPP3R1-4641RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3R1 Protein
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Cat.#:PPP3R1-5946CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP3R1
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Cat.#:PPP3R1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3R1 cell lysate
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Involved Pathway

PPP3R1 involved in several pathways and played different roles in them. We selected most pathways PPP3R1 participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF11; TAOK1; TRP53; CACNA1G; PRKCA; KCNA3; KRAS; RPS6KA2; FGF2; HSPA1B
Calcium signaling pathway
GRIN2D; GRM1; PPIAA; P2RX8; ADRB2; ITPKB; PTGER3; CACNA1G; CAMK2D1; TNNC1B
cGMP-PKG signaling pathway
Adcy4; PIK3R2; PPP3CA; PIK3CD; NOS3; AKT1; MYLK3; ATF4; PLCB1; PPP1CC
Oocyte meiosis
PPP3R1; ADCY1B; INS2; PPP2CA; FBXW11; ANAPC7; PPP2R5C; YWHAE; YWHAG; SGOL1
Apoptosis
BAXA; HIST1H1C; BIRC5A; Casp3; CASP6; PRKACAB; BAXB; IRF4A; TNFRSF1A; PRKAR1AB
Wnt signaling pathway
VANGL1; PRICKLE1A; NKD2B; PRKCA; WNT2BA; CSNK1A1L; RAC3; SFRP4; PPP3R1; NFATC3
Axon guidance
COL4A4; SEMA3B; GFRA4; GNAI1; PPP3CB; CFL1; FRS2B; DCX; PAK6; JAK3
VEGF signaling pathway
RAC3; PIK3R5; PPP3CB; AKT2; AKT3A; PIK3CG; HRAS; PPP3CA; PLCG2; HRASB
Osteoclast differentiation
PIK3R2; LILRA5; TRAF6; IFNGR1; FCGR1; PIK3CB; IKBKG; cgr2b; FOSL2; RELB
Natural killer cell mediated cytotoxicity
RAET1G; TNFRSF10B; PPP3R2; TYROBP; KLRC4-KLRK1; Ifna11; NCR3; RAET1D; HLA-G; IFNAR2
T cell receptor signaling pathway
CBLC; RHOA; PPP3R2; CD3E; CD3D; MUC1; MAP2K1; PIK3CD; NFATC2; NFKB1; FYN
B cell receptor signaling pathway
PILRB; INPP5D; PLCG2; MAPK1; PIK3CB; ACTR2; LAT2; GRB2; LYN; PIK3R2
Long-term potentiation
RAF1; PPP3CB; CAMK2G; RPS6KA2; CAMK4; CALM2; CALM4; PLCB4; GRIN2B; MAPK3
Glutamatergic synapse
SLC1A2; GRIA1; SLC1A1; GRIN3A; GRM5; GRIN2D; GRIK4; GRM4; GRIA2; PRKCB
Oxytocin signaling pathway
CACNA2D4; GNAI3; PPP3CB; CACNG4; PRKAG2; PLA2G4A; PRKCB; CACNG1; CAMKK1; PRKACB
Glucagon signaling pathway
CRTC2; CPT1C; PYGL; PPP3R2; PRMT1; CALML5; ITPR1; GNAS; PRKACB; PPARGC1A
Renin secretion
GNAI1; LOC100328615; PPP3CA; CALML5; PLCB3; CLCA4; PDE3A; PDE1A; PLCB1; GNAI3
Alzheimers disease
GRIN2D; NDUFS2; NDUFA1; ATP5G3; NDUFS7; COX5B; MAPK1; CALM4; ATP5F1; IDE
Amyotrophic lateral sclerosis (ALS)
DERL1; TNFRSF1A; APAF1; Casp3; MAPK12; CAT; TNFRSF1B; TOMM40L; CASP1; GRIN2C
Amphetamine addiction
GRIN3A; HDAC1; PPP3R1; CALM4; PDYN; PRKCA; PRKACB; CREB3L4; PRKACG; CREB3L3
Tuberculosis
MAPK12; HLA-DMB; ATP6V0B; IFNA21; CASP10; HLA-DQA2; CASP8; IFNB1; HSPD1; IL18
HTLV-I infection
Adcy4; DLG1; WNT9A; SMAD4; MAP3K14; Pdgfa&Pdgfb; TBP; ICAM1; FZD10; ITGB2L

Protein Function

PPP3R1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3R1 itself. We selected most functions PPP3R1 had, and list some proteins which have the same functions with PPP3R1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CRB2A; SLC25A24; EFCAB4B; EFCAB6; C2CD4B; S100A14; TBC1D9B; THBS4A; NUCB2; HMCN1
Function calcium-dependent protein serine/threonine phosphatase activity
Related Protein NETO2; PPP3R1; CAMK2G; PPP3CB
Function calmodulin binding
Related Protein NETO2; PLA2G6; MYO1F; MYO5B; NOS2; CNN3; CAMKVB; TJP1; AKAP5; INVS
Function protein binding
Related Protein APLP2; KRT6A; HDAC4; EMILIN1; GRIN2C; LRRC3; GRID2IP; CFL1; SGPL1; PVR
Function protein domain specific binding
Related Protein SCN5A; IST1; HNRNPM; CACNB2; NDE1; HIST1H4H; YWHAQB; IL1B; AIDA; TNNI3

Interacting Protein

PPP3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3R1.
PPP3CA; BCL2; CALM1; MAP3K5; NAP1L2; USP14; IQCB1

PPP3R1 Related Articles

Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).
Pinheiro, CS; Staub, O; et al. Characterization and binding affinities of SmLANP: A new Schistosoma mansoni member of the ANP32 family of regulatory proteins. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 165:95-102(2009).