ppp3r1
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  • Official Full Name
  • protein phosphatase 3, regulatory subunit B, alpha
  • Background
  • PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and
  • Synonyms
  • PPP3R1; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), reg; calcineurin subunit B type 1; calcineurin B; type I (19kDa); CALNB1; CNB; CNB1; protein phosphatase 2B regulatory subunit B alpha; CANB1_HUMAN; Cna2; PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1; OTTHUMP00000201952; OTTHUMP00000201960; OTTHUMP00000201961; calcineurin B, type I (19kDa); protein phosphatase 3 (formerly 2B), regulato
Cat.#:PPP3CA&PPP3R1-626HTag:
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PPP3CA&PPP3R1
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Cat.#:PPP3R1-1119HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1 protein, His & GST-tagged
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Cat.#:PPP3R1-1923HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1, GST-tagged
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Cat.#:PPP3R1-27208THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1, His-tagged
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Cat.#:PPP3R1-3471HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP3R1, His-tagged
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Cat.#:PPP3R1-7366HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3R1, His tagged
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Cat.#:PPP3R1-13269MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP3R1 Protein
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Cat.#:PPP3R1-4641RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3R1 Protein
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Cat.#:PPP3R1-5946CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP3R1
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Cat.#:PPP3R1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PPP3R1 cell lysate
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Involved Pathway

PPP3R1 involved in several pathways and played different roles in them. We selected most pathways PPP3R1 participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA2D3; TP53; CACNB4A; NRAS; PPM1BA; MAP2K4B; MKNK2B; MAP3K6; PPM1A; MAPK8B
Calcium signaling pathway
PDGFRB; ADRB3B; PTAFR; ADRB1; DRD7; GNA11A; SPHK2; HRH1; CHRNA7; HRH2
cGMP-PKG signaling pathway
PDE3B; AGTR1B; KCNJ8; MAPK3; SLC25A4; IRS2; MYLK3; ATP2A2; PLCB3; PDE2A
Oocyte meiosis
PPP1CB; PPP2R5EA; CAMK2D; PKMYT1; CCNE2; PLK1; RPS6KAL; CALM1B; PRKACAA; CPEB4
Apoptosis
RIPK1L; CRADD; HIST1H1A; CTNNB2; BCL2; CYCSB; CAPN2B; MYD88; DBNLB; CFLARA
Wnt signaling pathway
SMAD4; FZD7B; MYCB; PLCB3; CAMK2D1; RAC1; FBXW11A; RHOAB; CAMK2D; PLCB1
Axon guidance
SIAH2; PAK4; PITPNA; ITGB3A; GFRA4; SRGAP1; KBTBD7; RHOB; RHOAE; PPP3R1
VEGF signaling pathway
PPP3R1; PTGS2B; PRKCG; SRC; PTK2; PIK3R3A; RAC3B; PRKCBB; RAF1; PIK3R3B
Osteoclast differentiation
BTK; IKBKB; IFNAR1; LCP2; MAPK3; GAB2; MAPK12; PIK3CA; FCGR3B; TRAF6
Natural killer cell mediated cytotoxicity
IFNA10; SH2D1A; PRF1; RAF1; TNFRSF10C; IFNG; LCP2; KIR2DL3; IFNA17; CD48
T cell receptor signaling pathway
MAP2K2; PIK3R5; NCK2; PAK7; TEC; Il2; PAK6; PAK2; LCK; VAV3
B cell receptor signaling pathway
HDAC5; VAV3; LILRB3; PPP3CB; RAC3; RASGRP3; VAV2; PILRB; CD79B; SOS1
Long-term potentiation
RPS6KA1; CAMK2B; PRKCB; ATF4; PRKCA; BRAF; PPP1CC; PLCB3; PPP1R1A; RPS6KA2
Glutamatergic synapse
MAPK1; PLCB4; GNAS; GLUL; PLCB2; ITPR3; PLD1; GRIN1; GNG13; DLGAP1
Oxytocin signaling pathway
MAPK7; RCAN1; PIK3R5; MYL6; KCNJ14; GNAI1; PRKAG2; PPP3CB; CD38; MAP2K5
Glucagon signaling pathway
ITPR3; CALML5; CREB3L1; GYS1; SLC2A2; PKM2; CPT1C; PKM; G6PC; CAMK2B
Renin secretion
PLCB4; GUCY1B3; PPP3CC; CLCA2; CALM2; ORAI1; PDE1A; CLCA3; AGTR1B; PLCB1
Alzheimers disease
NDUFA13; NDUFB2; CALM4; NDUFB5; PLCB3; CALM2; CALML3; TNFRSF1A; mt-Atp8; RYR3
Amyotrophic lateral sclerosis (ALS)
NEFL; NEFH; TNFRSF1A; MAPK11; RAC1; PPP3CB; GRIA1; BID; DERL1; MAP3K5
Amphetamine addiction
CALML3; PPP3CC; PRKACB; NETO2; PPP3R1; STX1A; PRKCA; SIRT1; FOS; CREB5
Tuberculosis
FCGR2B; CASP10; RAB7A; HLA-DPB1; CD209; IFNGR2; EEA1; ATP6V0A1; RIPK2; RHOA
HTLV-I infection
MAP2K4; BUB1B; FOSL1; ITGB2L; GPS2; WNT10B; LTBR; HLA-DRA; FZD3; NFKB2

Protein Function

PPP3R1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3R1 itself. We selected most functions PPP3R1 had, and list some proteins which have the same functions with PPP3R1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein LALBA; PCDH2AC; CDH12A; PNLIPRP2; UBE4A; NCL; SYT7B; EPDR1; FSTL1A; EFHB
Function calcium-dependent protein serine/threonine phosphatase activity
Related Protein CAMK2G; PPP3R1; PPP3CB; NETO2
Function calmodulin binding
Related Protein CAMKK1; SPHK1; MAPKAPK2B; REM1; UPF3B; ARPP21; NOS1; MKNK2; ADD2; RRAD
Function protein binding
Related Protein CYTH2; RNF14; TAP1; ADRBK1; PYYA; IGHM; TEKT3; ESR1; REV1; SH2D3C
Function protein domain specific binding
Related Protein E2F4; STX1A; ITGA3; CNTROB; GSN; RCC2; MYO1D; TWIST2; EHD2; COX4I2

Interacting Protein

PPP3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3R1.
PPP3CA; BCL2; CALM1; MAP3K5; NAP1L2; USP14; IQCB1

PPP3R1 Related Articles

Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).
Pinheiro, CS; Staub, O; et al. Characterization and binding affinities of SmLANP: A new Schistosoma mansoni member of the ANP32 family of regulatory proteins. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 165:95-102(2009).